Evidence map›Paper›PMID 35506451›Full record

ReviewMolecular medicine reports2022

Mimiviruses: Giant viruses with novel and intriguing features (Review).

Eleni Kalafati, Eleni Papanikolaou, Evangelos Marinos, Nicholas P Anagnou, Kalliopi I Pappa

Open access · hybridAbstract readReview
In one paragraph

Review in Molecular medicine reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. Widespread Horizontal Gene Transfer Among Animal Viruses.bioRxiv : the preprint server for biology · 2024
    Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Eleni KalafatiLaboratory of Cell and Gene Therapy, Centre of Basic Research, Biomedical Research Foundation of The Academy of Athens (BRFAA), School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Eleni PapanikolaouLaboratory of Cell and Gene Therapy, Centre of Basic Research, Biomedical Research Foundation of The Academy of Athens (BRFAA), School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Evangelos MarinosLaboratory of Biology, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Nicholas P AnagnouLaboratory of Cell and Gene Therapy, Centre of Basic Research, Biomedical Research Foundation of The Academy of Athens (BRFAA), School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Kalliopi I PappaLaboratory of Cell and Gene Therapy, Centre of Basic Research, Biomedical Research Foundation of The Academy of Athens (BRFAA), School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Biomedical Research Foundation of the Academy of Athens · GRNational and Kapodistrian University of Athens · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Mimivirus is a giant virus that infects amoebae and was long considered to be a bacterium due to its size. The viral particles are composed of a protein capsid of ~500 nm in diameter, which is enclosed in a polysaccharide layer in which ~120‑140 nm long fibers are embedded, resulting in an overall diameter of 700 nm. The virus has a genome size of 1.2 Mb DNA, and surprisingly, replicates only in the cytoplasm of the infected cells without entering the nucleus, which is a unique characteristic among DNA viruses. Their existence is undeniable; however, as with any novel discovery, there is still uncertainty concerning their pathogenicity mechanisms in humans and the nature of the Mimivirus virophage resistance element system (MIMIVIRE), a term given to describe the immune network of the Mimivirus, which closely resembles the CRISPR‑Cas system. The scope of the present review is to discuss the recent developments derived from structural and functional studies performed on the distinctive characteristics of the Mimivirus, and from studies concerning their putative clinical relevance in humans.

Indexed as

AmoebaGiant VirusesMimiviridaeCapsidCRISPR-Cas SystemsHumansAcanthamoeba polyphagaMarseilleviridaeMimivirusMimivirus virophage resistance elementvirophages

Identifiers

PMID35506451
PMCPMC9133948
OpenAlexW4225124412

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.