ArticleMolecular plant pathology2022
Homeostasis of cell wall integrity pathway phosphorylation is required for the growth and pathogenicity of Magnaporthe oryzae.
Article in Molecular plant pathology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed.
- Regulator of G-Protein Signalling Protein AaRgs2 Negatively Regulates Appressorium-Like Formation of Alternaria alternata Induced by Pear Cutin Monomer via the AaRgs2-AaGα1-AaAC Module.Molecular plant pathology · 2026Article
- Oligosaccharide elicitors in plant immunity: Molecular mechanisms and disease resistance strategies.Plant communications · 2025Review
- Characterisation of guided entry of tail-anchored proteins in Magnaporthe oryzae.PLoS pathogens · 2025Article
- Type 2C Protein Phosphatase MoPtc6 Plays Critical Roles in the Development and Virulence ofJournal of fungi (Basel, Switzerland) · 2025Article
- Protein Phosphatases MoPtc5, MoPtc1, and MoPtc2 Contribute to the Vegetative Growth, Stress Adaptation, and Virulence ofJournal of fungi (Basel, Switzerland) · 2025Article
- Roles of theJournal of fungi (Basel, Switzerland) · 2025Article
- Dual activation of soybean resistance against Phytophthora sojae by pectin lyase and degraded pectin oligosaccharides.Science China. Life sciences · 2024Article
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- Pectate Lyase from Fusarium sacchari Induces Plant Immune Responses and Contributes to Virulence.Microbiology spectrum · 2023Article
- The Calcium Chloride Responsive Type 2C Protein Phosphatases Play Synergistic Roles in Regulating MAPK Pathways inJournal of fungi (Basel, Switzerland) · 2022Article
- Homeostasis of cell wall integrity pathway phosphorylation is required for the growth and pathogenicity of Magnaporthe oryzae.Molecular plant pathology · 2022Article
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8 authors.
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Abstract
The cell wall provides a crucial barrier to stress imposed by the external environment. In the rice blast fungus Magnaporthe oryzae, this stress response is mediated by the cell wall integrity (CWI) pathway, consisting of a well-characterized protein phosphorylation cascade. However, other regulators that maintain CWI phosphorylation homeostasis, such as protein phosphatases (PPases), remain unclear. Here, we identified two PPases, MoPtc1 and MoPtc2, that function as negative regulators of the CWI pathway. MoPtc1 and MoPtc2 interact with MoMkk1, one of the key components of the CWI pathway, and are crucial for the vegetative growth, conidial formation, and virulence of M. oryzae. We also demonstrate that both MoPtc1 and MoPtc2 dephosphorylate MoMkk1 in vivo and in vitro, and that CWI stress leads to enhanced interaction between MoPtc1 and MoMkk1. CWI stress abolishes the interaction between MoPtc2 and MoMkk1, providing a means of deactivation for CWI signalling. Our studies reveal that CWI signalling in M. oryzae is a highly coordinated regulatory mechanism vital for stress response and pathogenicity.
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