Evidence map›Paper›PMID 35506248›Full record

ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2022

Fertility Preservation and Financial Hardship among Adolescent and Young Adult Women with Cancer.

Clare Meernik, Jennifer E Mersereau, Christopher D Baggett, Stephanie M Engel, Lisa M Moy, Nancy T Cannizzaro, Mary Peavey, Lawrence H Kushi, Chun R Chao, Hazel B Nichols

Open access · bronzeAbstract read
In one paragraph

Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. The experience of fertility preservation decision-making in hematopoietic stem cell transplantation patients: a qualitative study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  6. Article
  7. Identifying Barriers to Fertility Preservation in Adolescent and Young Adult Cancer Patients.Canadian oncology nursing journal = Revue canadienne de nursing oncologique · 2026
    Article
  8. Article
  9. Canadian oncology nursing journal = Revue canadienne de nursing oncologique · 2026
    Article
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  13. Fertility Information Perceptions and Needs of People with Cancer, Their Family Members, and Caregivers.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Clare MeernikDepartment of Epidemiology, University of North Carolina at Chapel Hill Gillings School of Global Public Health, Chapel Hill, North Carolina.ORCID 0000-0002-8564-1266
Jennifer E MersereauDivision of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina.
Christopher D BaggettDepartment of Epidemiology, University of North Carolina at Chapel Hill Gillings School of Global Public Health, Chapel Hill, North Carolina.
Stephanie M EngelDepartment of Epidemiology, University of North Carolina at Chapel Hill Gillings School of Global Public Health, Chapel Hill, North Carolina.
Lisa M MoyDivision of Research, Kaiser Permanente Northern California, Oakland, California.
Nancy T CannizzaroDepartment of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, California.
Mary PeaveyAtlantic Reproductive Medicine Associates, Raleigh, North Carolina.
Lawrence H KushiDivision of Research, Kaiser Permanente Northern California, Oakland, California.ORCID 0000-0001-9136-1175
Chun R ChaoDepartment of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, California.ORCID 0000-0002-6072-4954
Hazel B NicholsDepartment of Epidemiology, University of North Carolina at Chapel Hill Gillings School of Global Public Health, Chapel Hill, North Carolina.ORCID 0000-0003-0972-1560
University of North Carolina at Chapel Hill · USKaiser Permanente · USReproductive Biology Associates · US

Funding

UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3M
Cancer Control Education ProgramT32CA057726 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Melissa B Gilkey, Melissa A. Troester · 2017 to 2026
$3.7M
Clinical Pregnancy Outcomes in Adolescent and Young Adult Female Cancer SurvivorsR01CA204258 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI NICHOLS, HAZEL B · 2017 to 2021
$3.4M
Assisted Reproductive Technology Use After Adolescent and Young Adult Cancer in North CarolinaF31CA260787 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MEERNIK, CLARE E · 2021 to 2021
$36k
NCI NIH HHS F31 CA260787NCI NIH HHS R01 CA204258NCI NIH HHS T32 CA057726NIEHS NIH HHS P30 ES010126
6 · The paper itself

Abstract

backgroundFinancial hardship among adolescents and young adults (AYA) with cancer who receive gonadotoxic treatments may be exacerbated by the use of fertility services. This study examined whether AYA women with cancer who used fertility preservation had increased financial hardship.

methodsAYA women with cancer in North Carolina and California completed a survey in 2018-2019. Cancer-related financial hardship was compared between women who cryopreserved oocytes or embryos for fertility preservation after cancer diagnosis (n = 65) and women who received gonadotoxic treatment and reported discussing fertility with their provider, but did not use fertility preservation (n = 491). Multivariable log-binomial regression was used to estimate prevalence ratios and 95% confidence intervals (CI).

resultsWomen were a median age of 33 years at diagnosis and 7 years from diagnosis at the time of survey. Women who used fertility preservation were primarily ages 25 to 34 years at diagnosis (65%), non-Hispanic White (72%), and had at least a Bachelor's degree (85%). In adjusted analysis, use of fertility preservation was associated with 1.50 times the prevalence of material financial hardship (95% CI: 1.08-2.09). The magnitude of hardship was also substantially higher among women who used fertility preservation: 12% reported debt of ≥$25,000 versus 5% in the referent group.

conclusionsThis study provides new evidence that cryopreserving oocytes or embryos after cancer diagnosis for future family building is associated with increased financial vulnerability. IMPACT: More legislation that mandates insurance coverage to mitigate hardships stemming from iatrogenic infertility could improve access to fertility preservation for young women with cancer.

Indexed as

Fertility PreservationNeoplasmsAdolescentFemaleFinancial StressHumansInsurance CoverageSurveys and QuestionnairesYoung Adult

Identifiers

PMID35506248
PMCPMC9074091
OpenAlexW4225405033

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.