Evidence map›Paper›PMID 35506243›Full record

ArticleAutophagy2023

Abnormal triaging of misfolded proteins by adult neuronal ceroid lipofuscinosis-associated DNAJC5/CSPα mutants causes lipofuscin accumulation.

Juhyung Lee, Yue Xu, Layla Saidi, Miao Xu, Konrad Zinsmaier, Yihong Ye

Open access · hybridAbstract read
In one paragraph

Article in Autophagy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 40 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Prolonged exposure to leisure screen time notably accelerates biological aging: Evidence from observational studies and genetic associations.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Observational
  9. Article
  10. Article
  11. Review
  12. Unifying biology of neurodegeneration in lysosomal storage diseases.Journal of inherited metabolic disease · 2025
    Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Frontiers in molecular neuroscience · 2024
    Review
  20. Intercellular transmission of alpha-synuclein.Frontiers in molecular neuroscience · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Juhyung LeeLaboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-3638-1496
Yue XuLaboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-0958-8846
Layla SaidiLaboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
Miao XuNational Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, USA.
Konrad ZinsmaierDepartments of Neuroscience and Molecular and Cellular Biology, University of Arizona, Tucson, AZ, USA.ORCID 0000-0002-9992-6238
Yihong YeLaboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-9512-7922
National Institutes of Health · USUniversity of Arizona · US

Funding

Unconventional protein secretion-mediated protein quality control in health and diseasesZIADK075143 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI YE, YIHONG · 2017 to 2025
$6.7M
Roles of protein misfolding in neurodegenerative diseasesZIADK075145 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI YE, YIHONG · 2017 to 2025
$6.6M
Cysteine-string Protein and NeurodegenerationR21NS117855 · NINDS · UNIVERSITY OF ARIZONA · PI ZINSMAIER, KONRAD ERNST · 2020 to 2020
$422k
NINDS NIH HHS R21 NS117855
6 · The paper itself

Abstract

Mutations in

Indexed as

HSP40 Heat-Shock ProteinsMembrane ProteinsNeuronal Ceroid-LipofuscinosesAutophagyEndosomal Sorting Complexes Required for TransportHumansLipofuscinMutationcysteine string proteinEndosomal Sorting Complexes Required for TransportHSP40 Heat-Shock ProteinsLipofuscinMembrane ProteinsCLN4cysteine string protein αDNAJC5/CSPαESCRTlysobodylysosome/endolysosomemicroautophagy/eMImisfolding-associated protein secretion/MAPSneuronal ceroid lipofuscinosis/NCLprotein quality control/PQCunconventional protein secretion/UPS

Identifiers

PMID35506243
PMCPMC9809949
OpenAlexW4229004730

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.