ArticleRadiology. Cardiothoracic imaging2022
Hepatosteatosis and Atherosclerotic Plaque at Coronary CT Angiography.
Open access · greenAbstract read
In one paragraph
Article in Radiology. Cardiothoracic imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 9 citations in OpenAlex.
- Coronary artery calcium score-emerging role for opportunistic screening on thoracic CT and novel applications.The British journal of radiology · 2026Review
- Heart-liver co-management: epidemiology, mechanisms, and novel therapeutic approaches for metabolic dysfunction-associated steatotic liver disease and coronary artery disease.Frontiers in cardiovascular medicine · 2026Review
- AI-quantified epicardial adipose tissue and prediction of future myocardial infarction in patients with cardiometabolic disease: a post-hoc analysis from the SCOT-HEART trial.Cardiovascular diabetology · 2025Article
- Non-Alcoholic Fatty Liver Disease and Coronary Artery Disease: A Bidirectional Association Based on Endothelial Dysfunction.International journal of molecular sciences · 2024Review
- Impact of Nonalcoholic Hepatic Steatosis on the Warranty Period of a Coronary Artery Calcium Score of 0: Results From the Multi-Ethnic Study of Atherosclerosis.Circulation. Cardiovascular imaging · 2024Article
- New Insights into Non-Alcoholic Fatty Liver Disease and Coronary Artery Disease: The Liver-Heart Axis.Life (Basel, Switzerland) · 2022Review
Corrections and comments
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Authors and funding
27 authors at 7 institutions in 5 countries.
Jessica CarterUniversity/BHF Centre for Cardiovascular Science, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, Scotland EH16 SUF, (J.C., M.N.M., E.T., J.K., M.D., A.J.M., P.D.A., A.H., S.A., A.S.V.S., T.P., C.W., N.L.M., M.R.D., D.E.N., M.C.W.); Liverpool Centre for Cardiovascular Science, Liverpool, England (T.D.H., S.W.M.); Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J.K.); Biomedical Imaging Research Institute and Division of Artificial Intelligence in Medicine, Cedars-Sinai Medical Center, Los Angeles, Calif (P.M., D.S.B., P.J.S., D.D.); Christchurch Heart Institute, University of Otago, Christchurch, New Zealand (P.D.A.); Department of Radiology, University of Cambridge, Cambridge, England (J.R.W.M.); Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland (G.R.); Edinburgh Imaging Facility QMRI, University of Edinburgh, Edinburgh, Scotland (E.J.R.v.B., M.R.D., D.E.N., M.C.W.); Royal Brompton and Harefield NHS Foundation Trust Departments of Cardiology and Radiology, London, England and the National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, England (E.D.N.); and Icahn School of Medicine, Weill Cornell Medical College, New York, NY (L.J.S.).ORCID https://orcid.org/0000-0002-9015-3216
Thomas D HeseltineUniversity/BHF Centre for Cardiovascular Science, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, Scotland EH16 SUF, (J.C., M.N.M., E.T., J.K., M.D., A.J.M., P.D.A., A.H., S.A., A.S.V.S., T.P., C.W., N.L.M., M.R.D., D.E.N., M.C.W.); Liverpool Centre for Cardiovascular Science, Liverpool, England (T.D.H., S.W.M.); Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J.K.); Biomedical Imaging Research Institute and Division of Artificial Intelligence in Medicine, Cedars-Sinai Medical Center, Los Angeles, Calif (P.M., D.S.B., P.J.S., D.D.); Christchurch Heart Institute, University of Otago, Christchurch, New Zealand (P.D.A.); Department of Radiology, University of Cambridge, Cambridge, England (J.R.W.M.); Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland (G.R.); Edinburgh Imaging Facility QMRI, University of Edinburgh, Edinburgh, Scotland (E.J.R.v.B., M.R.D., D.E.N., M.C.W.); Royal Brompton and Harefield NHS Foundation Trust Departments of Cardiology and Radiology, London, England and the National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, England (E.D.N.); and Icahn School of Medicine, Weill Cornell Medical College, New York, NY (L.J.S.).
Mohammed N MeahUniversity/BHF Centre for Cardiovascular Science, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, Scotland EH16 SUF, (J.C., M.N.M., E.T., J.K., M.D., A.J.M., P.D.A., A.H., S.A., A.S.V.S., T.P., C.W., N.L.M., M.R.D., D.E.N., M.C.W.); Liverpool Centre for Cardiovascular Science, Liverpool, England (T.D.H., S.W.M.); Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J.K.); Biomedical Imaging Research Institute and Division of Artificial Intelligence in Medicine, Cedars-Sinai Medical Center, Los Angeles, Calif (P.M., D.S.B., P.J.S., D.D.); Christchurch Heart Institute, University of Otago, Christchurch, New Zealand (P.D.A.); Department of Radiology, University of Cambridge, Cambridge, England (J.R.W.M.); Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland (G.R.); Edinburgh Imaging Facility QMRI, University of Edinburgh, Edinburgh, Scotland (E.J.R.v.B., M.R.D., D.E.N., M.C.W.); Royal Brompton and Harefield NHS Foundation Trust Departments of Cardiology and Radiology, London, England and the National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, England (E.D.N.); and Icahn School of Medicine, Weill Cornell Medical College, New York, NY (L.J.S.).
Evangelos TzolosUniversity/BHF Centre for Cardiovascular Science, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, Scotland EH16 SUF, (J.C., M.N.M., E.T., J.K., M.D., A.J.M., P.D.A., A.H., S.A., A.S.V.S., T.P., C.W., N.L.M., M.R.D., D.E.N., M.C.W.); Liverpool Centre for Cardiovascular Science, Liverpool, England (T.D.H., S.W.M.); Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J.K.); Biomedical Imaging Research Institute and Division of Artificial Intelligence in Medicine, Cedars-Sinai Medical Center, Los Angeles, Calif (P.M., D.S.B., P.J.S., D.D.); Christchurch Heart Institute, University of Otago, Christchurch, New Zealand (P.D.A.); Department of Radiology, University of Cambridge, Cambridge, England (J.R.W.M.); Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland (G.R.); Edinburgh Imaging Facility QMRI, University of Edinburgh, Edinburgh, Scotland (E.J.R.v.B., M.R.D., D.E.N., M.C.W.); Royal Brompton and Harefield NHS Foundation Trust Departments of Cardiology and Radiology, London, England and the National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, England (E.D.N.); and Icahn School of Medicine, Weill Cornell Medical College, New York, NY (L.J.S.).ORCID 0000-0003-0038-043X
Jacek KwiecinskiUniversity/BHF Centre for Cardiovascular Science, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, Scotland EH16 SUF, (J.C., M.N.M., E.T., J.K., M.D., A.J.M., P.D.A., A.H., S.A., A.S.V.S., T.P., C.W., N.L.M., M.R.D., D.E.N., M.C.W.); Liverpool Centre for Cardiovascular Science, Liverpool, England (T.D.H., S.W.M.); Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J.K.); Biomedical Imaging Research Institute and Division of Artificial Intelligence in Medicine, Cedars-Sinai Medical Center, Los Angeles, Calif (P.M., D.S.B., P.J.S., D.D.); Christchurch Heart Institute, University of Otago, Christchurch, New Zealand (P.D.A.); Department of Radiology, University of Cambridge, Cambridge, England (J.R.W.M.); Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland (G.R.); Edinburgh Imaging Facility QMRI, University of Edinburgh, Edinburgh, Scotland (E.J.R.v.B., M.R.D., D.E.N., M.C.W.); Royal Brompton and Harefield NHS Foundation Trust Departments of Cardiology and Radiology, London, England and the National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, England (E.D.N.); and Icahn School of Medicine, Weill Cornell Medical College, New York, NY (L.J.S.).
Mhairi DorisUniversity/BHF Centre for Cardiovascular Science, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, Scotland EH16 SUF, (J.C., M.N.M., E.T., J.K., M.D., A.J.M., P.D.A., A.H., S.A., A.S.V.S., T.P., C.W., N.L.M., M.R.D., D.E.N., M.C.W.); Liverpool Centre for Cardiovascular Science, Liverpool, England (T.D.H., S.W.M.); Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J.K.); Biomedical Imaging Research Institute and Division of Artificial Intelligence in Medicine, Cedars-Sinai Medical Center, Los Angeles, Calif (P.M., D.S.B., P.J.S., D.D.); Christchurch Heart Institute, University of Otago, Christchurch, New Zealand (P.D.A.); Department of Radiology, University of Cambridge, Cambridge, England (J.R.W.M.); Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland (G.R.); Edinburgh Imaging Facility QMRI, University of Edinburgh, Edinburgh, Scotland (E.J.R.v.B., M.R.D., D.E.N., M.C.W.); Royal Brompton and Harefield NHS Foundation Trust Departments of Cardiology and Radiology, London, England and the National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, England (E.D.N.); and Icahn School of Medicine, Weill Cornell Medical College, New York, NY (L.J.S.).
Priscilla McElhinneyUniversity/BHF Centre for Cardiovascular Science, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, Scotland EH16 SUF, (J.C., M.N.M., E.T., J.K., M.D., A.J.M., P.D.A., A.H., S.A., A.S.V.S., T.P., C.W., N.L.M., M.R.D., D.E.N., M.C.W.); Liverpool Centre for Cardiovascular Science, Liverpool, England (T.D.H., S.W.M.); Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J.K.); Biomedical Imaging Research Institute and Division of Artificial Intelligence in Medicine, Cedars-Sinai Medical Center, Los Angeles, Calif (P.M., D.S.B., P.J.S., D.D.); Christchurch Heart Institute, University of Otago, Christchurch, New Zealand (P.D.A.); Department of Radiology, University of Cambridge, Cambridge, England (J.R.W.M.); Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland (G.R.); Edinburgh Imaging Facility QMRI, University of Edinburgh, Edinburgh, Scotland (E.J.R.v.B., M.R.D., D.E.N., M.C.W.); Royal Brompton and Harefield NHS Foundation Trust Departments of Cardiology and Radiology, London, England and the National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, England (E.D.N.); and Icahn School of Medicine, Weill Cornell Medical College, New York, NY (L.J.S.).ORCID https://orcid.org/0000-0002-7642-6804
Alastair J MossUniversity/BHF Centre for Cardiovascular Science, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, Scotland EH16 SUF, (J.C., M.N.M., E.T., J.K., M.D., A.J.M., P.D.A., A.H., S.A., A.S.V.S., T.P., C.W., N.L.M., M.R.D., D.E.N., M.C.W.); Liverpool Centre for Cardiovascular Science, Liverpool, England (T.D.H., S.W.M.); Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J.K.); Biomedical Imaging Research Institute and Division of Artificial Intelligence in Medicine, Cedars-Sinai Medical Center, Los Angeles, Calif (P.M., D.S.B., P.J.S., D.D.); Christchurch Heart Institute, University of Otago, Christchurch, New Zealand (P.D.A.); Department of Radiology, University of Cambridge, Cambridge, England (J.R.W.M.); Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland (G.R.); Edinburgh Imaging Facility QMRI, University of Edinburgh, Edinburgh, Scotland (E.J.R.v.B., M.R.D., D.E.N., M.C.W.); Royal Brompton and Harefield NHS Foundation Trust Departments of Cardiology and Radiology, London, England and the National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, England (E.D.N.); and Icahn School of Medicine, Weill Cornell Medical College, New York, NY (L.J.S.).ORCID 0000-0003-4123-2070
Philip D AdamsonUniversity/BHF Centre for Cardiovascular Science, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, Scotland EH16 SUF, (J.C., M.N.M., E.T., J.K., M.D., A.J.M., P.D.A., A.H., S.A., A.S.V.S., T.P., C.W., N.L.M., M.R.D., D.E.N., M.C.W.); Liverpool Centre for Cardiovascular Science, Liverpool, England (T.D.H., S.W.M.); Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J.K.); Biomedical Imaging Research Institute and Division of Artificial Intelligence in Medicine, Cedars-Sinai Medical Center, Los Angeles, Calif (P.M., D.S.B., P.J.S., D.D.); Christchurch Heart Institute, University of Otago, Christchurch, New Zealand (P.D.A.); Department of Radiology, University of Cambridge, Cambridge, England (J.R.W.M.); Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland (G.R.); Edinburgh Imaging Facility QMRI, University of Edinburgh, Edinburgh, Scotland (E.J.R.v.B., M.R.D., D.E.N., M.C.W.); Royal Brompton and Harefield NHS Foundation Trust Departments of Cardiology and Radiology, London, England and the National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, England (E.D.N.); and Icahn School of Medicine, Weill Cornell Medical College, New York, NY (L.J.S.).ORCID 0000-0002-6177-956X
Amanda HunterUniversity/BHF Centre for Cardiovascular Science, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, Scotland EH16 SUF, (J.C., M.N.M., E.T., J.K., M.D., A.J.M., P.D.A., A.H., S.A., A.S.V.S., T.P., C.W., N.L.M., M.R.D., D.E.N., M.C.W.); Liverpool Centre for Cardiovascular Science, Liverpool, England (T.D.H., S.W.M.); Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J.K.); Biomedical Imaging Research Institute and Division of Artificial Intelligence in Medicine, Cedars-Sinai Medical Center, Los Angeles, Calif (P.M., D.S.B., P.J.S., D.D.); Christchurch Heart Institute, University of Otago, Christchurch, New Zealand (P.D.A.); Department of Radiology, University of Cambridge, Cambridge, England (J.R.W.M.); Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland (G.R.); Edinburgh Imaging Facility QMRI, University of Edinburgh, Edinburgh, Scotland (E.J.R.v.B., M.R.D., D.E.N., M.C.W.); Royal Brompton and Harefield NHS Foundation Trust Departments of Cardiology and Radiology, London, England and the National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, England (E.D.N.); and Icahn School of Medicine, Weill Cornell Medical College, New York, NY (L.J.S.).
Shirjel AlamUniversity/BHF Centre for Cardiovascular Science, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, Scotland EH16 SUF, (J.C., M.N.M., E.T., J.K., M.D., A.J.M., P.D.A., A.H., S.A., A.S.V.S., T.P., C.W., N.L.M., M.R.D., D.E.N., M.C.W.); Liverpool Centre for Cardiovascular Science, Liverpool, England (T.D.H., S.W.M.); Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J.K.); Biomedical Imaging Research Institute and Division of Artificial Intelligence in Medicine, Cedars-Sinai Medical Center, Los Angeles, Calif (P.M., D.S.B., P.J.S., D.D.); Christchurch Heart Institute, University of Otago, Christchurch, New Zealand (P.D.A.); Department of Radiology, University of Cambridge, Cambridge, England (J.R.W.M.); Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland (G.R.); Edinburgh Imaging Facility QMRI, University of Edinburgh, Edinburgh, Scotland (E.J.R.v.B., M.R.D., D.E.N., M.C.W.); Royal Brompton and Harefield NHS Foundation Trust Departments of Cardiology and Radiology, London, England and the National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, England (E.D.N.); and Icahn School of Medicine, Weill Cornell Medical College, New York, NY (L.J.S.).ORCID 0000-0002-2099-612X
Anoop S V ShahUniversity/BHF Centre for Cardiovascular Science, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, Scotland EH16 SUF, (J.C., M.N.M., E.T., J.K., M.D., A.J.M., P.D.A., A.H., S.A., A.S.V.S., T.P., C.W., N.L.M., M.R.D., D.E.N., M.C.W.); Liverpool Centre for Cardiovascular Science, Liverpool, England (T.D.H., S.W.M.); Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J.K.); Biomedical Imaging Research Institute and Division of Artificial Intelligence in Medicine, Cedars-Sinai Medical Center, Los Angeles, Calif (P.M., D.S.B., P.J.S., D.D.); Christchurch Heart Institute, University of Otago, Christchurch, New Zealand (P.D.A.); Department of Radiology, University of Cambridge, Cambridge, England (J.R.W.M.); Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland (G.R.); Edinburgh Imaging Facility QMRI, University of Edinburgh, Edinburgh, Scotland (E.J.R.v.B., M.R.D., D.E.N., M.C.W.); Royal Brompton and Harefield NHS Foundation Trust Departments of Cardiology and Radiology, London, England and the National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, England (E.D.N.); and Icahn School of Medicine, Weill Cornell Medical College, New York, NY (L.J.S.).
Tania PawadeUniversity/BHF Centre for Cardiovascular Science, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, Scotland EH16 SUF, (J.C., M.N.M., E.T., J.K., M.D., A.J.M., P.D.A., A.H., S.A., A.S.V.S., T.P., C.W., N.L.M., M.R.D., D.E.N., M.C.W.); Liverpool Centre for Cardiovascular Science, Liverpool, England (T.D.H., S.W.M.); Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J.K.); Biomedical Imaging Research Institute and Division of Artificial Intelligence in Medicine, Cedars-Sinai Medical Center, Los Angeles, Calif (P.M., D.S.B., P.J.S., D.D.); Christchurch Heart Institute, University of Otago, Christchurch, New Zealand (P.D.A.); Department of Radiology, University of Cambridge, Cambridge, England (J.R.W.M.); Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland (G.R.); Edinburgh Imaging Facility QMRI, University of Edinburgh, Edinburgh, Scotland (E.J.R.v.B., M.R.D., D.E.N., M.C.W.); Royal Brompton and Harefield NHS Foundation Trust Departments of Cardiology and Radiology, London, England and the National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, England (E.D.N.); and Icahn School of Medicine, Weill Cornell Medical College, New York, NY (L.J.S.).
Chengjia WangUniversity/BHF Centre for Cardiovascular Science, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, Scotland EH16 SUF, (J.C., M.N.M., E.T., J.K., M.D., A.J.M., P.D.A., A.H., S.A., A.S.V.S., T.P., C.W., N.L.M., M.R.D., D.E.N., M.C.W.); Liverpool Centre for Cardiovascular Science, Liverpool, England (T.D.H., S.W.M.); Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J.K.); Biomedical Imaging Research Institute and Division of Artificial Intelligence in Medicine, Cedars-Sinai Medical Center, Los Angeles, Calif (P.M., D.S.B., P.J.S., D.D.); Christchurch Heart Institute, University of Otago, Christchurch, New Zealand (P.D.A.); Department of Radiology, University of Cambridge, Cambridge, England (J.R.W.M.); Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland (G.R.); Edinburgh Imaging Facility QMRI, University of Edinburgh, Edinburgh, Scotland (E.J.R.v.B., M.R.D., D.E.N., M.C.W.); Royal Brompton and Harefield NHS Foundation Trust Departments of Cardiology and Radiology, London, England and the National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, England (E.D.N.); and Icahn School of Medicine, Weill Cornell Medical College, New York, NY (L.J.S.).ORCID 0000-0003-2345-7364
Jonathan R Weir-McCallUniversity/BHF Centre for Cardiovascular Science, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, Scotland EH16 SUF, (J.C., M.N.M., E.T., J.K., M.D., A.J.M., P.D.A., A.H., S.A., A.S.V.S., T.P., C.W., N.L.M., M.R.D., D.E.N., M.C.W.); Liverpool Centre for Cardiovascular Science, Liverpool, England (T.D.H., S.W.M.); Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J.K.); Biomedical Imaging Research Institute and Division of Artificial Intelligence in Medicine, Cedars-Sinai Medical Center, Los Angeles, Calif (P.M., D.S.B., P.J.S., D.D.); Christchurch Heart Institute, University of Otago, Christchurch, New Zealand (P.D.A.); Department of Radiology, University of Cambridge, Cambridge, England (J.R.W.M.); Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland (G.R.); Edinburgh Imaging Facility QMRI, University of Edinburgh, Edinburgh, Scotland (E.J.R.v.B., M.R.D., D.E.N., M.C.W.); Royal Brompton and Harefield NHS Foundation Trust Departments of Cardiology and Radiology, London, England and the National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, England (E.D.N.); and Icahn School of Medicine, Weill Cornell Medical College, New York, NY (L.J.S.).ORCID https://orcid.org/0000-0001-5842-842X
Giles RoditiUniversity/BHF Centre for Cardiovascular Science, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, Scotland EH16 SUF, (J.C., M.N.M., E.T., J.K., M.D., A.J.M., P.D.A., A.H., S.A., A.S.V.S., T.P., C.W., N.L.M., M.R.D., D.E.N., M.C.W.); Liverpool Centre for Cardiovascular Science, Liverpool, England (T.D.H., S.W.M.); Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J.K.); Biomedical Imaging Research Institute and Division of Artificial Intelligence in Medicine, Cedars-Sinai Medical Center, Los Angeles, Calif (P.M., D.S.B., P.J.S., D.D.); Christchurch Heart Institute, University of Otago, Christchurch, New Zealand (P.D.A.); Department of Radiology, University of Cambridge, Cambridge, England (J.R.W.M.); Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland (G.R.); Edinburgh Imaging Facility QMRI, University of Edinburgh, Edinburgh, Scotland (E.J.R.v.B., M.R.D., D.E.N., M.C.W.); Royal Brompton and Harefield NHS Foundation Trust Departments of Cardiology and Radiology, London, England and the National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, England (E.D.N.); and Icahn School of Medicine, Weill Cornell Medical College, New York, NY (L.J.S.).ORCID 0000-0001-9393-7764
Edwin J R van BeekUniversity/BHF Centre for Cardiovascular Science, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, Scotland EH16 SUF, (J.C., M.N.M., E.T., J.K., M.D., A.J.M., P.D.A., A.H., S.A., A.S.V.S., T.P., C.W., N.L.M., M.R.D., D.E.N., M.C.W.); Liverpool Centre for Cardiovascular Science, Liverpool, England (T.D.H., S.W.M.); Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J.K.); Biomedical Imaging Research Institute and Division of Artificial Intelligence in Medicine, Cedars-Sinai Medical Center, Los Angeles, Calif (P.M., D.S.B., P.J.S., D.D.); Christchurch Heart Institute, University of Otago, Christchurch, New Zealand (P.D.A.); Department of Radiology, University of Cambridge, Cambridge, England (J.R.W.M.); Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland (G.R.); Edinburgh Imaging Facility QMRI, University of Edinburgh, Edinburgh, Scotland (E.J.R.v.B., M.R.D., D.E.N., M.C.W.); Royal Brompton and Harefield NHS Foundation Trust Departments of Cardiology and Radiology, London, England and the National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, England (E.D.N.); and Icahn School of Medicine, Weill Cornell Medical College, New York, NY (L.J.S.).ORCID https://orcid.org/0000-0002-2777-5071
Edward D NicolUniversity/BHF Centre for Cardiovascular Science, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, Scotland EH16 SUF, (J.C., M.N.M., E.T., J.K., M.D., A.J.M., P.D.A., A.H., S.A., A.S.V.S., T.P., C.W., N.L.M., M.R.D., D.E.N., M.C.W.); Liverpool Centre for Cardiovascular Science, Liverpool, England (T.D.H., S.W.M.); Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J.K.); Biomedical Imaging Research Institute and Division of Artificial Intelligence in Medicine, Cedars-Sinai Medical Center, Los Angeles, Calif (P.M., D.S.B., P.J.S., D.D.); Christchurch Heart Institute, University of Otago, Christchurch, New Zealand (P.D.A.); Department of Radiology, University of Cambridge, Cambridge, England (J.R.W.M.); Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland (G.R.); Edinburgh Imaging Facility QMRI, University of Edinburgh, Edinburgh, Scotland (E.J.R.v.B., M.R.D., D.E.N., M.C.W.); Royal Brompton and Harefield NHS Foundation Trust Departments of Cardiology and Radiology, London, England and the National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, England (E.D.N.); and Icahn School of Medicine, Weill Cornell Medical College, New York, NY (L.J.S.).
Leslee J ShawUniversity/BHF Centre for Cardiovascular Science, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, Scotland EH16 SUF, (J.C., M.N.M., E.T., J.K., M.D., A.J.M., P.D.A., A.H., S.A., A.S.V.S., T.P., C.W., N.L.M., M.R.D., D.E.N., M.C.W.); Liverpool Centre for Cardiovascular Science, Liverpool, England (T.D.H., S.W.M.); Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J.K.); Biomedical Imaging Research Institute and Division of Artificial Intelligence in Medicine, Cedars-Sinai Medical Center, Los Angeles, Calif (P.M., D.S.B., P.J.S., D.D.); Christchurch Heart Institute, University of Otago, Christchurch, New Zealand (P.D.A.); Department of Radiology, University of Cambridge, Cambridge, England (J.R.W.M.); Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland (G.R.); Edinburgh Imaging Facility QMRI, University of Edinburgh, Edinburgh, Scotland (E.J.R.v.B., M.R.D., D.E.N., M.C.W.); Royal Brompton and Harefield NHS Foundation Trust Departments of Cardiology and Radiology, London, England and the National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, England (E.D.N.); and Icahn School of Medicine, Weill Cornell Medical College, New York, NY (L.J.S.).
Daniel S BermanUniversity/BHF Centre for Cardiovascular Science, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, Scotland EH16 SUF, (J.C., M.N.M., E.T., J.K., M.D., A.J.M., P.D.A., A.H., S.A., A.S.V.S., T.P., C.W., N.L.M., M.R.D., D.E.N., M.C.W.); Liverpool Centre for Cardiovascular Science, Liverpool, England (T.D.H., S.W.M.); Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J.K.); Biomedical Imaging Research Institute and Division of Artificial Intelligence in Medicine, Cedars-Sinai Medical Center, Los Angeles, Calif (P.M., D.S.B., P.J.S., D.D.); Christchurch Heart Institute, University of Otago, Christchurch, New Zealand (P.D.A.); Department of Radiology, University of Cambridge, Cambridge, England (J.R.W.M.); Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland (G.R.); Edinburgh Imaging Facility QMRI, University of Edinburgh, Edinburgh, Scotland (E.J.R.v.B., M.R.D., D.E.N., M.C.W.); Royal Brompton and Harefield NHS Foundation Trust Departments of Cardiology and Radiology, London, England and the National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, England (E.D.N.); and Icahn School of Medicine, Weill Cornell Medical College, New York, NY (L.J.S.).ORCID 0000-0002-3793-9578
Piotr J SlomkaUniversity/BHF Centre for Cardiovascular Science, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, Scotland EH16 SUF, (J.C., M.N.M., E.T., J.K., M.D., A.J.M., P.D.A., A.H., S.A., A.S.V.S., T.P., C.W., N.L.M., M.R.D., D.E.N., M.C.W.); Liverpool Centre for Cardiovascular Science, Liverpool, England (T.D.H., S.W.M.); Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J.K.); Biomedical Imaging Research Institute and Division of Artificial Intelligence in Medicine, Cedars-Sinai Medical Center, Los Angeles, Calif (P.M., D.S.B., P.J.S., D.D.); Christchurch Heart Institute, University of Otago, Christchurch, New Zealand (P.D.A.); Department of Radiology, University of Cambridge, Cambridge, England (J.R.W.M.); Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland (G.R.); Edinburgh Imaging Facility QMRI, University of Edinburgh, Edinburgh, Scotland (E.J.R.v.B., M.R.D., D.E.N., M.C.W.); Royal Brompton and Harefield NHS Foundation Trust Departments of Cardiology and Radiology, London, England and the National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, England (E.D.N.); and Icahn School of Medicine, Weill Cornell Medical College, New York, NY (L.J.S.).ORCID https://orcid.org/0000-0002-6110-938X
Nicholas L MillsUniversity/BHF Centre for Cardiovascular Science, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, Scotland EH16 SUF, (J.C., M.N.M., E.T., J.K., M.D., A.J.M., P.D.A., A.H., S.A., A.S.V.S., T.P., C.W., N.L.M., M.R.D., D.E.N., M.C.W.); Liverpool Centre for Cardiovascular Science, Liverpool, England (T.D.H., S.W.M.); Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J.K.); Biomedical Imaging Research Institute and Division of Artificial Intelligence in Medicine, Cedars-Sinai Medical Center, Los Angeles, Calif (P.M., D.S.B., P.J.S., D.D.); Christchurch Heart Institute, University of Otago, Christchurch, New Zealand (P.D.A.); Department of Radiology, University of Cambridge, Cambridge, England (J.R.W.M.); Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland (G.R.); Edinburgh Imaging Facility QMRI, University of Edinburgh, Edinburgh, Scotland (E.J.R.v.B., M.R.D., D.E.N., M.C.W.); Royal Brompton and Harefield NHS Foundation Trust Departments of Cardiology and Radiology, London, England and the National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, England (E.D.N.); and Icahn School of Medicine, Weill Cornell Medical College, New York, NY (L.J.S.).ORCID 0000-0003-0533-7991
Marc R DweckUniversity/BHF Centre for Cardiovascular Science, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, Scotland EH16 SUF, (J.C., M.N.M., E.T., J.K., M.D., A.J.M., P.D.A., A.H., S.A., A.S.V.S., T.P., C.W., N.L.M., M.R.D., D.E.N., M.C.W.); Liverpool Centre for Cardiovascular Science, Liverpool, England (T.D.H., S.W.M.); Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J.K.); Biomedical Imaging Research Institute and Division of Artificial Intelligence in Medicine, Cedars-Sinai Medical Center, Los Angeles, Calif (P.M., D.S.B., P.J.S., D.D.); Christchurch Heart Institute, University of Otago, Christchurch, New Zealand (P.D.A.); Department of Radiology, University of Cambridge, Cambridge, England (J.R.W.M.); Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland (G.R.); Edinburgh Imaging Facility QMRI, University of Edinburgh, Edinburgh, Scotland (E.J.R.v.B., M.R.D., D.E.N., M.C.W.); Royal Brompton and Harefield NHS Foundation Trust Departments of Cardiology and Radiology, London, England and the National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, England (E.D.N.); and Icahn School of Medicine, Weill Cornell Medical College, New York, NY (L.J.S.).ORCID 0000-0001-9847-5917
David E NewbyUniversity/BHF Centre for Cardiovascular Science, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, Scotland EH16 SUF, (J.C., M.N.M., E.T., J.K., M.D., A.J.M., P.D.A., A.H., S.A., A.S.V.S., T.P., C.W., N.L.M., M.R.D., D.E.N., M.C.W.); Liverpool Centre for Cardiovascular Science, Liverpool, England (T.D.H., S.W.M.); Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J.K.); Biomedical Imaging Research Institute and Division of Artificial Intelligence in Medicine, Cedars-Sinai Medical Center, Los Angeles, Calif (P.M., D.S.B., P.J.S., D.D.); Christchurch Heart Institute, University of Otago, Christchurch, New Zealand (P.D.A.); Department of Radiology, University of Cambridge, Cambridge, England (J.R.W.M.); Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland (G.R.); Edinburgh Imaging Facility QMRI, University of Edinburgh, Edinburgh, Scotland (E.J.R.v.B., M.R.D., D.E.N., M.C.W.); Royal Brompton and Harefield NHS Foundation Trust Departments of Cardiology and Radiology, London, England and the National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, England (E.D.N.); and Icahn School of Medicine, Weill Cornell Medical College, New York, NY (L.J.S.).ORCID 0000-0001-7971-4628
Scott W MurrayUniversity/BHF Centre for Cardiovascular Science, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, Scotland EH16 SUF, (J.C., M.N.M., E.T., J.K., M.D., A.J.M., P.D.A., A.H., S.A., A.S.V.S., T.P., C.W., N.L.M., M.R.D., D.E.N., M.C.W.); Liverpool Centre for Cardiovascular Science, Liverpool, England (T.D.H., S.W.M.); Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J.K.); Biomedical Imaging Research Institute and Division of Artificial Intelligence in Medicine, Cedars-Sinai Medical Center, Los Angeles, Calif (P.M., D.S.B., P.J.S., D.D.); Christchurch Heart Institute, University of Otago, Christchurch, New Zealand (P.D.A.); Department of Radiology, University of Cambridge, Cambridge, England (J.R.W.M.); Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland (G.R.); Edinburgh Imaging Facility QMRI, University of Edinburgh, Edinburgh, Scotland (E.J.R.v.B., M.R.D., D.E.N., M.C.W.); Royal Brompton and Harefield NHS Foundation Trust Departments of Cardiology and Radiology, London, England and the National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, England (E.D.N.); and Icahn School of Medicine, Weill Cornell Medical College, New York, NY (L.J.S.).
Damini DeyUniversity/BHF Centre for Cardiovascular Science, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, Scotland EH16 SUF, (J.C., M.N.M., E.T., J.K., M.D., A.J.M., P.D.A., A.H., S.A., A.S.V.S., T.P., C.W., N.L.M., M.R.D., D.E.N., M.C.W.); Liverpool Centre for Cardiovascular Science, Liverpool, England (T.D.H., S.W.M.); Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J.K.); Biomedical Imaging Research Institute and Division of Artificial Intelligence in Medicine, Cedars-Sinai Medical Center, Los Angeles, Calif (P.M., D.S.B., P.J.S., D.D.); Christchurch Heart Institute, University of Otago, Christchurch, New Zealand (P.D.A.); Department of Radiology, University of Cambridge, Cambridge, England (J.R.W.M.); Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland (G.R.); Edinburgh Imaging Facility QMRI, University of Edinburgh, Edinburgh, Scotland (E.J.R.v.B., M.R.D., D.E.N., M.C.W.); Royal Brompton and Harefield NHS Foundation Trust Departments of Cardiology and Radiology, London, England and the National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, England (E.D.N.); and Icahn School of Medicine, Weill Cornell Medical College, New York, NY (L.J.S.).ORCID https://orcid.org/0000-0003-2236-6970
Michelle C WilliamsUniversity/BHF Centre for Cardiovascular Science, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, Scotland EH16 SUF, (J.C., M.N.M., E.T., J.K., M.D., A.J.M., P.D.A., A.H., S.A., A.S.V.S., T.P., C.W., N.L.M., M.R.D., D.E.N., M.C.W.); Liverpool Centre for Cardiovascular Science, Liverpool, England (T.D.H., S.W.M.); Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J.K.); Biomedical Imaging Research Institute and Division of Artificial Intelligence in Medicine, Cedars-Sinai Medical Center, Los Angeles, Calif (P.M., D.S.B., P.J.S., D.D.); Christchurch Heart Institute, University of Otago, Christchurch, New Zealand (P.D.A.); Department of Radiology, University of Cambridge, Cambridge, England (J.R.W.M.); Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland (G.R.); Edinburgh Imaging Facility QMRI, University of Edinburgh, Edinburgh, Scotland (E.J.R.v.B., M.R.D., D.E.N., M.C.W.); Royal Brompton and Harefield NHS Foundation Trust Departments of Cardiology and Radiology, London, England and the National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, England (E.D.N.); and Icahn School of Medicine, Weill Cornell Medical College, New York, NY (L.J.S.).ORCID 0000-0003-3556-2428
University of Edinburgh · GBCedars-Sinai Medical Center · USCornell University · USInstitute of Cardiology · PLNew Zealand Brain Research Institute · NZRoyal Brompton & Harefield NHS Foundation Trust · GBUniversity of Glasgow · GB
Funding
British Heart Foundation CH/09/002British Heart Foundation CH/F/21/90010British Heart Foundation FS/14/78/31020British Heart Foundation FS/16/14/32023British Heart Foundation FS/19/46/34445British Heart Foundation FS/ICRF/20/26002British Heart Foundation RE/18/5/34216British Heart Foundation RG/16/10/32375British Heart Foundation RG/20/10/34966
Abstract
Purpose: To assess the association between nonalcoholic fatty liver disease (NAFLD) and quantitative atherosclerotic plaque at CT. Materials and Methods: In this post hoc analysis of the prospective Scottish Computed Tomography of the HEART trial (November 2010 to September 2014), hepatosteatosis and coronary artery calcium score were measured at noncontrast CT. Presence of stenoses, visually assessed high-risk plaque, and quantitative plaque burden were assessed at coronary CT angiography. Multivariable models were constructed to assess the impact of hepatosteatosis and cardiovascular risk factors on coronary artery disease. Results: Images from 1726 participants (mean age, 58 years ± 9 [SD]; 974 men) were included. Participants with hepatosteatosis (155 of 1726, 9%) had a higher body mass index, more hypertension and diabetes mellitus, and higher cardiovascular risk scores ( Conclusion: Hepatosteatosis at CT was associated with an increased prevalence of coronary artery disease at CT, but this was not independent of the presence of cardiovascular risk factors.
Indexed as
CardiacCoronary Artery DiseaseCTHepatosteatosisNonalcoholic Fatty Liver DiseasePlaque Quantification
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