Evidence map›Paper›PMID 35506094›Full record

ArticlePulmonary circulation2022

Ingenuity pathway analysis of the human cardiac cell Atlas identifies differences between right and left ventricular cardiomyocytes.

Sasha Z Prisco, Felipe Kazmirczak, Thenappan Thenappan, Kurt W Prins

Open access · goldAbstract read
In one paragraph

Article in Pulmonary circulation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Sasha Z PriscoDepartment of Medicine, Cardiovascular Division, Lillehei Heart Institute University of Minnesota Minneapolis Minnesota USA.
Felipe KazmirczakDepartment of Medicine, Cardiovascular Division, Lillehei Heart Institute University of Minnesota Minneapolis Minnesota USA.
Thenappan ThenappanDepartment of Medicine, Cardiovascular Division, Lillehei Heart Institute University of Minnesota Minneapolis Minnesota USA.
Kurt W PrinsDepartment of Medicine, Cardiovascular Division, Lillehei Heart Institute University of Minnesota Minneapolis Minnesota USA.
Minneapolis Heart Institute Foundation · USUniversity of Minnesota · US

Funding

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR002494 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R, WEISDORF, DANIEL J · 2018 to 2022
$34.9M
Training in Mechanisms of Cardiovascular DiseasesT32HL072742 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI TOBACMAN, LARRY S · 2003 to 2013
$3.7M
Training Program in Cardiac InnovationT32HL144472 · NHLBI · UNIVERSITY OF MINNESOTA · PI Peter A Crawford, SAMUEL C DUDLEY · 2019 to 2026
$2.6M
Mechanisms of Junctophilin-2 Misregulation that contribute to right ventricular dysfunction in pulmonary arterial hypertensionK08HL140100 · NHLBI · UNIVERSITY OF MINNESOTA · PI PRINS, KURT W · 2018 to 2022
$785k
Influences of sex hormones on the microtubule cytoskeleton in right ventricular dysfunctionF32HL154533 · NHLBI · UNIVERSITY OF MINNESOTA · PI PRISCO, SASHA ZHENG · 2021 to 2021
$73k
NCATS NIH HHS UL1 TR002494NHLBI NIH HHS K08 HL140100NHLBI NIH HHS T32 HL072742NHLBI NIH HHS T32 HL144472
6 · The paper itself

Abstract

Pharmaceuticals for left ventricular (LV) dysfunction do not have similar success in right ventricular (RV) failure, which may reflect biological differences between the ventricles. In this study, we performed Ingenuity Pathway Analysis of the Human Cell Atlas to understand how the transcriptomic signatures of the RV and LV differ.

Indexed as

heart diseasespulmonary heart diseaseright ventricle function and dysfunction

Identifiers

PMID35506094
PMCPMC9052994
OpenAlexW4200357827

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.