Evidence map›Paper›PMID 35506083›Full record

ArticlePulmonary circulation2022

Fecal matter transplant from Ace2 overexpressing mice counteracts chronic hypoxia-induced pulmonary hypertension.

Aline C Oliveira, Tao Yang, Jing Li, Ravindra K Sharma, Marianthi K Karas, Andrew J Bryant, Annette D de Kloet, Eric G Krause, Bina Joe, Elaine M Richards and 1 more

Open access · goldAbstract read
In one paragraph

Article in Pulmonary circulation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Aline C OliveiraDepartment of Physiology and Functional Genomics, College of Medicine University of Florida Gainesville Florida USA.
Tao YangDepartment of Physiology and Pharmacology, College of Medicine and Life Sciences, Center for Hypertension and Precision Medicine University of Toledo Toledo Ohio USA.
Jing LiDepartment of Physiology and Functional Genomics, College of Medicine University of Florida Gainesville Florida USA.
Ravindra K SharmaDepartment of Medicine, Division of Nephrology, Hypertension and Renal Transplantation University of Florida College of Medicine Gainesville Flora USA.
Marianthi K KarasDepartment of Physiology and Functional Genomics, College of Medicine University of Florida Gainesville Florida USA.
Andrew J BryantDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, College of Medicine University of Florida Gainesville Florida USA.
Annette D de KloetDepartment of Physiology and Functional Genomics, College of Medicine University of Florida Gainesville Florida USA.
Eric G KrauseDepartment of Pharmacodynamics, College of Pharmacy University of Florida Gainesville Florida USA.
Bina JoeDepartment of Physiology and Pharmacology, College of Medicine and Life Sciences, Center for Hypertension and Precision Medicine University of Toledo Toledo Ohio USA.
Elaine M RichardsDepartment of Physiology and Functional Genomics, College of Medicine University of Florida Gainesville Florida USA.
Mohan K RaizadaDepartment of Physiology and Functional Genomics, College of Medicine University of Florida Gainesville Florida USA.
Florida College · USUniversity of Florida · USUniversity of Toledo · US

Funding

Angiotensin-Converting Enzyme2 in Vascular Endothelial FunctionR01HL102033 · NHLBI · UNIVERSITY OF FLORIDA · PI RAIZADA, MOHAN K. · 2010 to 2019
$4.3M
Genetic, Epigenetic and Dietary Salt effects on Microbiota and HypertensionR01HL143082 · NHLBI · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI JOE, BINA · 2018 to 2021
$2.6M
Vascular Reparative Mechanism by ACE2/Ang-(1-7)in DiabetesR01HL110170 · NHLBI · UNIVERSITY OF FLORIDA · PI GRANT, MARIA BARTOLOMEO · 2011 to 2015
$2.2M
NHLBI NIH HHS R01 HL102033NHLBI NIH HHS R01 HL110170NHLBI NIH HHS R01 HL143082
6 · The paper itself

Abstract

Recent evidence suggests pulmonary hypertension (PH), a disease of the pulmonary vasculature actually has multiorgan pathophysiology and perhaps etiology. Herein, we demonstrated that fecal matter transplantation from angiotensin-converting enzyme 2 overexpressing mice counteracted the effects of chronic hypoxia to prevent pulmonary hypertension, neuroinflammation, and gut dysbiosis in wild type recipients.

Indexed as

microbiotaneuroinflammationrenin angiotensin system and pathophysiology

Identifiers

PMID35506083
PMCPMC9052990
OpenAlexW4200548086

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.