Evidence map›Paper›PMID 35505970›Full record

ArticleBurns & trauma2022

Non-severe burn injury increases cancer incidence in mice and has long-term impacts on the activation and function of T cells.

Lucy W Barrett, Vanessa S Fear, Bree Foley, Katherine Audsley, Samantha Barnes, Hannah Newnes, Alison McDonnell, Fiona M Wood, Mark W Fear, Jason Waithman

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Burns & trauma, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Lucy W BarrettBurn Injury Research Unit, School of Biomedical Sciences, University of Western Australia, Crawley, WA, 6009, Australia.ORCID https://orcid.org/0000-0001-9733-9841
Vanessa S FearTelethon Kids Institute, University of Western Australia, Northern Entrance, Perth Children's Hospital, 15 Hospital Ave, Nedlands, WA, 6009, Australia.
Bree FoleyTelethon Kids Institute, University of Western Australia, Northern Entrance, Perth Children's Hospital, 15 Hospital Ave, Nedlands, WA, 6009, Australia.
Katherine AudsleyTelethon Kids Institute, University of Western Australia, Northern Entrance, Perth Children's Hospital, 15 Hospital Ave, Nedlands, WA, 6009, Australia.
Samantha BarnesTelethon Kids Institute, University of Western Australia, Northern Entrance, Perth Children's Hospital, 15 Hospital Ave, Nedlands, WA, 6009, Australia.
Hannah NewnesTelethon Kids Institute, University of Western Australia, Northern Entrance, Perth Children's Hospital, 15 Hospital Ave, Nedlands, WA, 6009, Australia.
Alison McDonnellTelethon Kids Institute, University of Western Australia, Northern Entrance, Perth Children's Hospital, 15 Hospital Ave, Nedlands, WA, 6009, Australia.
Fiona M WoodBurn Injury Research Unit, School of Biomedical Sciences, University of Western Australia, Crawley, WA, 6009, Australia.
Mark W FearFiona Wood Foundation, Fiona Stanley Hospital, MNH (B), Main Hospital, CD 15, Level 4, Burns Unit, 102-118 Murdoch Drive, Murdoch, WA, 6150, Australia.ORCID https://orcid.org/0000-0003-3163-4666
Jason WaithmanTelethon Kids Institute, University of Western Australia, Northern Entrance, Perth Children's Hospital, 15 Hospital Ave, Nedlands, WA, 6009, Australia.
The Kids Research Institute Australia · AUFiona Stanley Hospital · AUThe University of Western Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Recent evidence suggests that burn patients are at increased risk of hospital admission for infection, mental health conditions, cardiovascular disease and cancer for many years after discharge for the burn injury itself. Burn injury has also been shown to induce sustained immune system dysfunction. This change to immune function may contribute to the increased risk of chronic disease observed. However, the mechanisms that disrupt long-term immune function in response to burn trauma, and their link to long-term morbidity, remain unknown. In this study we investigated changes to immune function after burn injury using a murine model of non-severe injury. Methods: An established mouse model of non-severe burn injury (full thickness burn equivalent to 8% total body surface area) was used in combination with an orthotopic model of B16 melanoma to investigate the link between burns and cancer. Considering that CD8 Results: We demonstrate that 4 weeks after a non-severe burn injury, mice were significantly more susceptible to tumour development than controls using an orthotopic model of B16 melanoma. In addition, our results reveal that CD8 Conclusions: Our data suggests that CD8

Indexed as

Burn injuryCancerImmune dysfunctionImmunologySurgeryT cells

Identifiers

PMID35505970
PMCPMC9054911
OpenAlexW4226096795

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.