ArticleCurrent research in neurobiology2021
Early life sleep disruption alters glutamate and dendritic spines in prefrontal cortex and impairs cognitive flexibility in prairie voles.
Article in Current research in neurobiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Social compatibility in opposite-sex prairie vole pairs is modulated by early-life sleep experience.PLoS biology · 2026Article
- Associations Between REM Sleep-like Posture Expression and Cognitive Flexibility in 2-Month-Old Japanese Black Calves.Animals : an open access journal from MDPI · 2025Article
- Neurotype matching in monogamous rodents is modulated by early-life sleep experience.bioRxiv : the preprint server for biology · 2025Article
- Article
- Excitatory/Inhibitory imbalance as a mechanism linking autism and sleep problems.Current opinion in neurobiology · 2025Review
- Sex-Specific Impacts of Early Life Sleep Disruption: Ethanol Seeking, Social Interaction, and Anxiety Are Differentially Altered in Adolescent Prairie Voles.Developmental psychobiology · 2024Article
- Early-life sleep disruption impairs subtle social behaviours in prairie voles: a pose-estimation study.Royal Society open science · 2023Article
- Sleep across the first year of life is prospectively associated with brain volume in 12-months old infants.Neurobiology of sleep and circadian rhythms · 2023Article
- Critical periods and Autism Spectrum Disorders, a role for sleep.Neurobiology of sleep and circadian rhythms · 2023Article
- Ontogenesis of the molecular response to sleep loss.Neurobiology of sleep and circadian rhythms · 2023Article
- Early life sleep disruption has long lasting, sex specific effects on later development of sleep in prairie voles.Neurobiology of sleep and circadian rhythms · 2023Article
- Loss of sleep when it is needed most - Consequences of persistent developmental sleep disruption: A scoping review of rodent models.Neurobiology of sleep and circadian rhythms · 2023Article
- Ontogenesis of the molecular response to sleep loss.bioRxiv : the preprint server for biology · 2023Article
- Early life sleep disruption potentiates lasting sex-specific changes in behavior in genetically vulnerable Shank3 heterozygous autism model mice.Molecular autism · 2022Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
Early life experiences are crucial for proper organization of excitatory synapses within the brain, with outsized effects on late-maturing, experience-dependent regions such as the medial prefrontal cortex (mPFC). Previous work in our lab showed that early life sleep disruption (ELSD) from postnatal days 14-21 in the highly social prairie vole results in long lasting impairments in social behavior. Here, we further hypothesized that ELSD alters glutamatergic synapses in mPFC, thereby affecting cognitive flexibility, an mPFC-dependent behavior. ELSD caused impaired cued fear extinction (indicating cognitive inflexibility), increased dendritic spine density, and decreased glutamate immunogold-labeling in vesicular glutamate transporter 1 (vGLUT1)-labeled presynaptic nerve terminals within mPFC. Our results have profound implications for neurodevelopmental disorders in humans such as autism spectrum disorder that also show poor sleep, impaired social behavior, cognitive inflexibility, as well as altered dendritic spine density and glutamate changes in mPFC, and imply that poor sleep may cause these changes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.