ArticleJPGN reports2022
Pediatric Acute Liver Failure Due to Type 2 Autoimmune Hepatitis Associated With SARS-CoV-2 Infection: A Case Report.
Article in JPGN reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 13 citations in OpenAlex.
- Histopathological impact of SARS-CoV-2 on the liver: Cellular damage and long-term complications.World journal of gastroenterology · 2024Review
- Concurrent, New-Onset Autoimmune Hepatitis, Celiac Disease, and Hashimoto's Thyroiditis Following COVID-19: A Case Report.JPGN reports · 2023Article
- Liver Damage and COVID-19: At Least a "Two-Hit" Story in Systematic Review.Current issues in molecular biology · 2023Review
- Outcomes in Patients with Liver Dysfunction Post SARS-CoV-2 Infection: What Should We Measure?Hepatic medicine : evidence and research · 2023Review
- An urgent call to identify the probable cause of severe acute hepatitis outbreak in children.Medicine in microecology · 2022Article
- High population burden of Omicron variant (B.1.1.529) is associated with the emergence of severe hepatitis of unknown etiology in children.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2022Article
- Severe Acute Hepatitis of Unknown Origin in Children: What Do We Know Today?Journal of clinical and translational hepatology · 2022Review
- A surge of pediatric hepatitis: Why SARS-CoV-2 should be considered guilty until proven innocent.Annals of medicine and surgery (2012) · 2022Article
- Acute Hepatitis of Unknown Origin in Children: Early Observations from the 2022 Outbreak.Journal of clinical and translational hepatology · 2022Review
- [The investigation on the acute, severe hepatitis of unknown origin in children].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2022Article
- COVID-19-associated liver injury, role of drug therapy and management: a review.Egyptian liver journal · 2022Review
- Hepatitis of unknown etiology in children: What we know and what we can do?Frontiers in microbiology · 2022Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although elevated liver enzymes are common in hospitalized children with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, pediatric acute liver failure is an uncommon manifestation of COVID-19 disease. We describe the case of a 3-year-old previously healthy female who developed acute liver failure secondary to type 2 autoimmune hepatitis preceded by mild infection with SARS-CoV-2. Testing for viral hepatitis was negative, and the patient did not meet diagnostic criteria for multisystem inflammatory disease in children (MIS-C). A liver biopsy showed acute submassive hepatocyte necrosis with brisk CD3+ T lymphocyte infiltration and no evidence of fibrosis or chronic liver disease. Treatment with high-dose methylprednisolone resulted in rapid normalization of alanine aminotransferase (ALT), aspartate aminotransferase (AST), international normalized ratio (INR), and ammonia levels, and liver transplantation was avoided. This case highlights a possible association between SARS-CoV-2 infection and subsequent development of autoimmune liver disease presenting with acute liver failure.
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