Evidence map›Paper›PMID 35505608›Full record

ArticleBiophysical journal2022

Adhesion strength between cells regulate nonmonotonic growth by a biomechanical feedback mechanism.

Abdul N Malmi-Kakkada, Sumit Sinha, Xin Li, D Thirumalai

Open access · greenAbstract read
In one paragraph

Article in Biophysical journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. On the control of cell proliferation.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  4. Capturing the mechanosensitivity of cell proliferation in models of epithelium.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  5. Article
  6. Article
  7. Article
  8. Mechanical control of cell proliferation patterns in growing tissues.bioRxiv : the preprint server for biology · 2023
    Article
  9. Migration and division in cell monolayers on substrates with topological defects.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  10. Biophysics of cancer.Biophysical journal · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Abdul N Malmi-KakkadaDepartment of Chemistry and Physics, Augusta University, Augusta, Georgia. Electronic address: amalmikakkada@augusta.edu.
Sumit SinhaDepartment of Physics, University of Texas at Austin, Austin, Texas.
Xin LiDepartment of Chemistry, University of Texas at Austin, Austin, Texas.
D ThirumalaiDepartment of Chemistry, University of Texas at Austin, Austin, Texas. Electronic address: dave.thirumalai@gmail.com.
The University of Texas at Austin · USAugusta University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We determine how intercellular interactions and mechanical pressure experienced by single cells regulate cell proliferation using a minimal computational model for three-dimensional multicellular spheroid (MCS) growth. We discover that emergent spatial variations in the cell division rate, depending on the location of the cells either at the core or periphery within the MCS, is regulated by intercellular adhesion strength (f

Indexed as

Spheroids, CellularCell AdhesionCell DivisionCell ProliferationFeedback

Identifiers

PMID35505608
PMCPMC9617137
OpenAlexW4225271142

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.