ArticleJournal of periodontal & implant science2022
Differential gene expression profiles of periodontal soft tissue from rat teeth after immediate and delayed replantation: a pilot study.
Article in Journal of periodontal & implant science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- In vitro biocompatibility evaluation of three-dimensionally printed resin crowns for primary molars.Odontology · 2026Article
- Osteogenic potential of Frondoside A in human periodontal ligament cells: an RNA-Seq analysis.Journal of periodontal & implant science · 2024Article
- Time-course study of genetic changes in periodontal ligament regeneration after tooth replantation in a mouse model.Scientific reports · 2024Article
- Evaluation of delphinidin as a storage medium for avulsed teeth.BMC oral health · 2023Article
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Authors and funding
5 authors.
Funding
Abstract
purposeIn dental avulsion, delayed replantation usually has an uncertain prognosis. After tooth replantation, complex inflammatory responses promote a return to periodontal tissue homeostasis. Various types of cytokines are produced in the inflammatory microenvironment, and these cytokines determine the periodontal tissue response. This study aimed to identify the gene expression profiles of replanted teeth and evaluate the functional differences between immediate and delayed replantation.
methodsMaxillary molars from Sprague-Dawley rats were extracted, exposed to a dry environment, and then replanted. The animals were divided into 2 groups according to the extra-oral time: immediate replantation (dry for 5 minutes) and delayed replantation (dry for 60 minutes). Either 3 or 7 days after replantation, the animals were sacrificed. Periodontal soft tissues were harvested for mRNA sequencing. Hallmark gene set enrichment analysis was performed to predict the function of gene-gene interactions. The normalized enrichment score (NES) was calculated to determine functional differences.
resultsThe hallmark gene sets enriched in delayed replantation at 3 days were oxidative phosphorylation (NES=2.82,
conclusionsDifferentially expressed gene profiles were significantly different between immediate and delayed replantation. TNF-α signaling via the NF-κB pathway was marked during the healing process. However, the enrichment score of this pathway changed in a time-dependent manner between immediate and delayed replantation.
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