Evidence map›Paper›PMID 35505416›Full record

SynthesisClinical epigenetics2022

Maternal iron status in early pregnancy and DNA methylation in offspring: an epigenome-wide meta-analysis.

M J Taeubert, P de Prado-Bert, M L Geurtsen, G Mancano, M J Vermeulen, I K M Reiss, D Caramaschi, J Sunyer, G C Sharp, J Julvez and 2 more

Open access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Clinical epigenetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Micronutrient regulation of the DNA methylome.Frontiers in epigenetics and epigenomics · 2024
    Review
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 4 countries.

M J Taeubert *The Generation R Study Group, Erasmus University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands.
P de Prado-Bert *ISGlobal, Barcelona, Spain.
M L GeurtsenThe Generation R Study Group, Erasmus University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands.
G MancanoMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
M J VermeulenDepartment of Pediatrics, Sophia's Children's Hospital, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
I K M ReissDepartment of Pediatrics, Sophia's Children's Hospital, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
D CaramaschiCollege of Life and Environmental Sciences, Psychology, University of Exeter, Exeter, UK.
J SunyerISGlobal, Barcelona, Spain.
G C SharpMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
J JulvezISGlobal, Barcelona, Spain.
M U Muckenthaler *Department of Pediatric Oncology, Hematology and Immunology, University Medical Center Heidelberg, Heidelberg, Germany.
J F Felix *The Generation R Study Group, Erasmus University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands. j.felix@erasmusmc.nl.ORCID 0000-0002-9801-5774
Erasmus MC · NLHeidelberg University · DEUniversitat Pompeu Fabra · ESInstitut de Recerca Biomèdica Catalunya Sud · ESUniversity of Bristol · GBUniversity Of Bristol Dental Hospital · GBUniversity of Exeter · GB

Funding

Does epigenetic methylation explain the gender-switch in adolescent asthma?R01AI121226 · NIAID · UNIVERSITY OF MEMPHIS · PI HOLLOWAY, JOHN W, ZHANG, HONGMEI · 2016 to 2020
$3.2M
Epigenetic Pathways to Conduct Problem Trajectories: Early Environmental RisksR01HD068437 · NICHD · KING'S COLLEGE LONDON · PI BARKER, EDWARD D., MILL, JONATHAN · 2012 to 2014
$1.1M
Biotechnology and Biological Sciences Research Council BB/I025263/1Biotechnology and Biological Sciences Research Council BB/I025751/1Medical Research Council MC_PC_21038Medical Research Council MC_UU_00011/1Medical Research Council MC_UU_00011/5Medical Research Council MC_UU_00011/6Medical Research Council MC_UU_12013_1Medical Research Council MC_UU_12013_2Medical Research Council MC_UU_12013_5Medical Research Council MC_UU_12013_8Medical Research Council MR/S009310/1Medical Research Council MR/S036520/1NIAID NIH HHS R01 AI121226NICHD NIH HHS R01 HD068437Wellcome TrustWellcome Trust 217065/Z/19/Z
6 · The paper itself

Abstract

backgroundUnbalanced iron homeostasis in pregnancy is associated with an increased risk of adverse birth and childhood health outcomes. DNA methylation has been suggested as a potential underlying mechanism linking environmental exposures such as micronutrient status during pregnancy with offspring health. We performed a meta-analysis on the association of maternal early-pregnancy serum ferritin concentrations, as a marker of body iron stores, and cord blood DNA methylation. We included 1286 mother-newborn pairs from two population-based prospective cohorts. Serum ferritin concentrations were measured in early pregnancy. DNA methylation was measured with the Infinium HumanMethylation450 BeadChip (Illumina). We examined epigenome-wide associations of maternal early-pregnancy serum ferritin and cord blood DNA methylation using robust linear regression analyses, with adjustment for confounders and performed fixed-effects meta-analyses. We additionally examined whether associations of any CpGs identified in cord blood persisted in the peripheral blood of older children and explored associations with other markers of maternal iron status. We also examined whether similar findings were present in the association of cord blood serum ferritin concentrations with cord blood DNA methylation.

resultsMaternal early-pregnancy serum ferritin concentrations were inversely associated with DNA methylation at two CpGs (cg02806645 and cg06322988) in PRR23A and one CpG (cg04468817) in PRSS22. Associations at two of these CpG sites persisted at each of the follow-up time points in childhood. Cord blood serum ferritin concentrations were not associated with cord blood DNA methylation levels at the three identified CpGs.

conclusionMaternal early-pregnancy serum ferritin concentrations were associated with lower cord blood DNA methylation levels at three CpGs and these associations partly persisted in older children. Further studies are needed to uncover the role of these CpGs in the underlying mechanisms of the associations of maternal iron status and offspring health outcomes.

Indexed as

DNA MethylationEpigenomeAdolescentChildEpigenesis, GeneticFemaleFerritinsGenome-Wide Association StudyHumansInfant, NewbornIronPregnancyProspective StudiesFerritinsIronDifferentially methylated regionsDNA methylationEpigeneticsIron metabolismMaternal serum ferritin

Identifiers

PMID35505416
PMCPMC9066980
OpenAlexW4225303634

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.