ReviewMalaria journal2022
Why Plasmodium vivax and Plasmodium falciparum are so different? A tale of two clades and their species diversities.
Review in Malaria journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Association of uric acid levels with severity of Plasmodium infections: a systematic review and meta-analysis.Scientific reports · 2023Pooled it
- The monophyly of Nycteria and Polychromophilus parasites: a missing piece in the evolution of malaria and other Haemosporida.Malaria journal · 2026Article
- An abundant merozoite surface protein ofeLife · 2026Article
- Extreme Genetic Diversity and Signatures of Balancing Selection in Plasmodium vivax Blood-Stage Antigens.The Journal of infectious diseases · 2026Article
- Contrasting evolutionary trajectories of pyrimethamine resistance in human and zoonotic malaria parasites.Malaria journal · 2026Article
- Novel zoonotic cases of Plasmodium simium from São Paulo with a reference genome of the Brazilian strain.Scientific reports · 2025Article
- High Prevalence, Genetic Diversity and Temporal Differentiation of Plasmodium vivax in a Remote Hard-to-Reach Community from the Peruvian Amazon Region.The American journal of tropical medicine and hygiene · 2025Article
- Computational Analysis of Plasmodium falciparum DNA Damage Inducible Protein 1 (PfDdi1): Insights into Binding of Artemisinin and its Derivatives and Implications for Antimalarial Drug Design.Cell biochemistry and biophysics · 2025Article
- Article
- Molecular Screening ofAnimals : an open access journal from MDPI · 2025Article
- Prevalence and Association of Malaria With ABO Blood Groups in Bosaso City, Puntland, Somalia: A Cross-Sectional Study.Health science reports · 2025Article
- The essential genome ofScience (New York, N.Y.) · 2025Article
- Supersaturation mutagenesis reveals adaptive rewiring of essential genes among malaria parasites.Science (New York, N.Y.) · 2025Article
- Utilisation of an in vivo malaria model to provide functional proof for RhopH1/CLAG essentiality and conserved orthology with P. falciparum.Journal of biomedical science · 2025Article
- Malaria Trends, Burden, Seasonal Variation, and Interventions in Western Tigray, Ethiopia.Journal of tropical medicine · 2025Article
- Dynamics of IgM and IgG Antibody Response Profile against Linear B-Cell Epitopes from Exoerythrocytic (CelTOS and TRAP) and Erythrocytic (CyRPA) Phases ofAntibodies (Basel, Switzerland) · 2024Article
- Investigation of Mutations in theMicroorganisms · 2024Article
- Origin of the human malaria parasite Plasmodium vivax.Trends in parasitology · 2024Review
- Hyper-diverse antigenic variation and resilience to transmission-reducing intervention in falciparum malaria.medRxiv : the preprint server for health sciences · 2024Article
- The Genome of Plasmodium gonderi: Insights into the Evolution of Human Malaria Parasites.Genome biology and evolution · 2024Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The global malaria burden sometimes obscures that the genus Plasmodium comprises diverse clades with lineages that independently gave origin to the extant human parasites. Indeed, the differences between the human malaria parasites were highlighted in the classical taxonomy by dividing them into two subgenera, the subgenus Plasmodium, which included all the human parasites but Plasmodium falciparum that was placed in its separate subgenus, Laverania. Here, the evolution of Plasmodium in primates will be discussed in terms of their species diversity and some of their distinct phenotypes, putative molecular adaptations, and host-parasite biocenosis. Thus, in addition to a current phylogeny using genome-level data, some specific molecular features will be discussed as examples of how these parasites have diverged. The two subgenera of malaria parasites found in primates, Plasmodium and Laverania, reflect extant monophyletic groups that originated in Africa. However, the subgenus Plasmodium involves species in Southeast Asia that were likely the result of adaptive radiation. Such events led to the Plasmodium vivax lineage. Although the Laverania species, including P. falciparum, has been considered to share "avian characteristics," molecular traits that were likely in the common ancestor of primate and avian parasites are sometimes kept in the Plasmodium subgenus while being lost in Laverania. Assessing how molecular traits in the primate malaria clades originated is a fundamental science problem that will likely provide new targets for interventions. However, given that the genus Plasmodium is paraphyletic (some descendant groups are in other genera), understanding the evolution of malaria parasites will benefit from studying "non-Plasmodium" Haemosporida.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.