Evidence map›Paper›PMID 35505122›Full record

Trial reportEuropean journal of nutrition2022

Improved microvascular reactivity after aged garlic extract intake is not mediated by hydrogen sulfide in older adults at risk for cardiovascular disease: a randomized clinical trial.

Renata Leitão, Gustavo Vieira de Oliveira, Cristina Rezende, Mônica Volino-Souza, Jacilene Mesquita, Leandro Lara de Carvalho, Thiago Silveira Alvares

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04008693 (Effect of Aged Garlic on Vascular Function and Muscle Oxygenation Responses in the Elderly), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04008693 nacompletednot on this map

Effect of Aged Garlic on Vascular Function and Muscle Oxygenation Responses in the Elderly

TypeinterventionalSponsorUniversidade Federal do Rio de JaneiroRan2019 to 2020Enrolled28ConditionsAging, Hypertension, Dyslipidemias, Abdominal ObesityArmsAged Garlic Extract, Placebo
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 2 countries.

Renata LeitãoNutrition and Exercise Metabolism Research Group, Food and Nutrition Institute, Federal University of Rio de Janeiro, Macaé Campus, Multidisciplinary Center UFRJ-Macaé, Estrada do Imburo, s/n, Macaé, RJ, 27979-000, Brazil.
Gustavo Vieira de OliveiraNutrition and Exercise Metabolism Research Group, Food and Nutrition Institute, Federal University of Rio de Janeiro, Macaé Campus, Multidisciplinary Center UFRJ-Macaé, Estrada do Imburo, s/n, Macaé, RJ, 27979-000, Brazil.
Cristina RezendeNutrition and Exercise Metabolism Research Group, Food and Nutrition Institute, Federal University of Rio de Janeiro, Macaé Campus, Multidisciplinary Center UFRJ-Macaé, Estrada do Imburo, s/n, Macaé, RJ, 27979-000, Brazil.
Mônica Volino-SouzaNutrition and Exercise Metabolism Research Group, Food and Nutrition Institute, Federal University of Rio de Janeiro, Macaé Campus, Multidisciplinary Center UFRJ-Macaé, Estrada do Imburo, s/n, Macaé, RJ, 27979-000, Brazil.
Jacilene MesquitaNutrition and Exercise Metabolism Research Group, Food and Nutrition Institute, Federal University of Rio de Janeiro, Macaé Campus, Multidisciplinary Center UFRJ-Macaé, Estrada do Imburo, s/n, Macaé, RJ, 27979-000, Brazil.
Leandro Lara de CarvalhoLaboratory of Catalysis and Synthesis of Bioactivity Substances, Federal University of Rio de Janeiro, Estrada do Imburo, s/n, Macaé, 27979-000, RJ, Brazil.
Thiago Silveira AlvaresNutrition and Exercise Metabolism Research Group, Food and Nutrition Institute, Federal University of Rio de Janeiro, Macaé Campus, Multidisciplinary Center UFRJ-Macaé, Estrada do Imburo, s/n, Macaé, RJ, 27979-000, Brazil. alvares@macae.ufrj.br.ORCID http://orcid.org/0000-0002-2261-8501
Universidade Federal do Rio de Janeiro · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study aimed to investigate the effects of AGE on microvascular reactivity, systolic blood pressure (SBP), and diastolic blood pressure (DBP) in older individuals at high risk for cardiovascular disease (CVD). Urinary thiosulfate was also investigated as an indirect marker of endogenous hydrogen sulfide (H

methodsTwenty-eight participants (14 male), 67 ± 6 years old with CVD risk factors, ingested 2.4 g of AGE or placebo (PLA). Near-infrared spectroscopy evaluated tissue oxygen saturation (StO

resultsThe upslope of StO

conclusionThis study demonstrated that a single dose of AGE improved microvascular reactivity in older adults at risk of CVD despite such an effect was not linked with urinary thiosulfate levels. This trial was registered at clinicaltrials.gov as NCT04008693 (May 19, 2020).

Indexed as

Cardiovascular DiseasesGarlicHydrogen SulfideAgedHumansMaleMicrocirculationMiddle AgedMuscle, SkeletalOxygen ConsumptionPlant ExtractsPolyestersThiosulfatesHydrogen SulfidePlant ExtractsPolyestersThiosulfatesBioactive compoundsFunctional foodsMicrocirculationMicrovascular functionMuscle oxygen saturationThiosulfate

Identifiers

PMID35505122
OpenAlexW4225415195

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.