ArticleMolecular psychiatry2022
Magical thinking in individuals with high polygenic risk for schizophrenia but no non-affective psychoses-a general population study.
Article in Molecular psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- The many manifestations of magical thinking: a systematic review.Frontiers in psychiatry · 2026Pooled it
- Impact of age of onset on the course of chronic schizophrenia: factors associated with first hospitalization in a large-scale cross-sectional study.European archives of psychiatry and clinical neuroscience · 2026Article
- Childhood family environment and systemic haemodynamics in adulthood: the Cardiovascular Risk in Young Finns Study.Scandinavian journal of public health · 2025Article
- Naturalistic Psychedelic Use and Psychotic Symptoms: A Cross-Sectional Study of Individuals with a Personal or Family History of Psychotic or Bipolar Disorders.Psychedelic medicine (New Rochelle, N.Y.) · 2025Article
- Childhood family environment and μ-opioid receptor availability in vivo in adulthood.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Delusion-like thinking is associated with lower individual alpha peak frequency.Schizophrenia (Heidelberg, Germany) · 2025Article
- Polygenic risk for schizophrenia and subjective well-being in a general population sample.Psychological medicine · 2025Article
- Polygenic risk for schizophrenia, social dispositions, and pace of epigenetic aging: Results from the Young Finns Study.Aging cell · 2024Article
- Differential relationship between meditation methods and psychotic-like and mystical experiences.PloS one · 2024Article
- Neural Signatures of Predictive Strategies Track Individuals Along the Autism-Schizophrenia Continuum.Schizophrenia bulletin · 2023Article
- Antivax attitude in the general population along the autism-schizophrenia continuum and the impact of socio-demographic factors.Frontiers in psychology · 2023Article
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A strong genetic background for psychoses is well-established. Most individuals with a high genetic risk for schizophrenia, however, do not develop the disorder. We investigated whether individuals, who have a high genetic risk for schizophrenia but no non-affective psychotic disorders, are predisposed to develop milder forms of deviant thinking in terms of magical thinking. Participants came from the population-based Young Finns Study (n = 1292). The polygenic risk score for schizophrenia (PRS) was calculated on the basis of the most recent genome-wide association study (GWAS). Psychiatric diagnoses over the lifespan were collected up to 2017 from the registry of hospital care. Magical thinking was evaluated with the Spiritual Acceptance Scale (e.g., beliefs in telepathy, miracles, mystical events, or sixth sense) of the Temperament and Character Inventory in 1997, 2001, and 2012 (participants were 20-50-year-olds). We found that, among those who did not develop non-affective psychotic disorders, high PRS predicted higher magical thinking in adulthood (p = 0.001). Further, PRS predicted different developmental courses: a low PRS predicted a steady decrease in magical thinking from age 20 to 50 years, while in individuals with high PRS the decrease in magical thinking ceased in middle age so that their level of magical thinking remained higher than expected for that age. These findings remained when controlling for sex, childhood family environment, and adulthood socioeconomic factors. In conclusion, if high PRS does not lead to a non-affective psychotic disorder, it predicts milder forms of deviant thinking such as elevated magical thinking in adulthood, especially in middle age. The finding enhances our understanding of different outcomes of high genetic psychosis risk.
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