Evidence map›Paper›PMID 35505080›Full record

ReviewPediatric research2023

Probiotic supplementation for neonates with congenital gastrointestinal surgical conditions: guidelines for future research.

Shripada Rao, Meera Esvaran, Liwei Chen, Chooi Kok, Anthony D Keil, Ian Gollow, Karen Simmer, Bernd Wemheuer, Patricia Conway, Sanjay Patole

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Pediatric research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Shripada RaoNeonatal Intensive Care Unit, Perth Children's Hospital, Perth, WA, Australia. shripada.rao@health.wa.gov.au.
Meera EsvaranCentre for Marine Science and Innovation at the University of New South Wales (UNSW), Sydney, NSW, Australia.
Liwei ChenSchool of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore, Singapore.
Chooi KokNeonatal Intensive Care Unit, Perth Children's Hospital, Perth, WA, Australia.
Anthony D KeilDepartment of Microbiology, PathWest Laboratory Medicine, Perth, WA, Australia.
Ian GollowDepartment of Paediatric Surgery, Perth Children's Hospital, Perth, WA, Australia.
Karen SimmerNeonatal Intensive Care Unit, Perth Children's Hospital, Perth, WA, Australia.
Bernd WemheuerCentre for Marine Science and Innovation at the University of New South Wales (UNSW), Sydney, NSW, Australia.
Patricia ConwayCentre for Marine Science and Innovation at the University of New South Wales (UNSW), Sydney, NSW, Australia.
Sanjay PatoleNeonatal Intensive Care Unit, Perth Children's Hospital, Perth, WA, Australia.
Perth Children's HospitalNanyang Technological University · SGUNSW Sydney · AUPathwest Laboratory Medicine · AUPrincess Margaret Hospital for Children · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Our pilot RCT found that probiotic supplementation with the three-strain bifidobacterial product (B. breve M-16V, B. longum subsp. infantis M-63 and B. longum subsp. longum BB536) attenuates gut dysbiosis, increases stool short-chain fatty acid (SCFA) levels and improves the growth of head circumference in neonates with congenital gastrointestinal surgical conditions (CGISC). In this article, we have provided guidelines for designing future multicentre RCTs based on the experience gained from our pilot RCT. The recommendations include advice about sample size, potential confounders, outcomes of interest, probiotic strain selection, storage, dose, duration and microbial quality assurance, collection of stool samples, storage and analysis and reporting. Following these guidelines will increase the validity of future RCTs in this area and hence confidence in their results. IMPACT: Probiotic supplementation attenuates gut dysbiosis, increases stool short-chain fatty acid (SCFA) levels and improves the growth of head circumference in neonates with congenital gastrointestinal surgical conditions. The current review provides evidence-based guidelines to conduct adequately powered RCTs in this field.

Indexed as

Gastrointestinal DiseasesProbioticsBifidobacteriumDysbiosisFecesHumansInfant, Newborn

Identifiers

PMID35505080
PMCPMC9876795
OpenAlexW4225321088

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.