ArticleMethods in molecular biology (Clifton, N.J.)2022
Detection of Paraptosis After Photodynamic Therapy.
Article in Methods in molecular biology (Clifton, N.J.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
5 citing papers in PubMed, 5 citations in OpenAlex.
- Translational issues with phototherapy of cancer.Translational oncology · 2026Review
- Photodynamic Therapy for Glioblastoma: Potential Application of TiOPharmaceutics · 2025Review
- Subcellular Organelle-Targeted Drug Delivery of Photodynamic Therapy and Gas-Photodynamic Combination Therapy.International journal of nanomedicine · 2025Review
- Article
- Overcoming the effects of fluid shear stress in ovarian cancer cell lines: Doxorubicin alone or photodynamic priming to target platinum resistance.Photochemistry and photobiologyArticle
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Photodynamic therapy (PDT) is a procedure for the selective photosensitization of neoplastic tissues. Subsequent irradiation with visible light can lead to cell death along with vascular shutdown and other responses that lead to selective eradication of malignant cells. Among the cellular responses to PDT are necrosis, apoptosis, and autophagy. These pathways have generally been associated with cell death, although autophagy can also be cytoprotective. A fourth effect that has hitherto been somewhat neglected is termed "paraptosis," a lethal response that can be identified by detecting an extensive collection of cytoplasmic vacuoles. Unlike autophagy, these vacuoles are bound by single membranes. Paraptosis has been characterized as a response to misfolded endoplasmic reticulum proteins that must be "cleared" if the affected cell is to survive. At present, there is no simple biochemical test for paraptosis. This chapter describes the procedure for detection of paraptosis using phase-contrast microscopy, along with some confirmatory approaches.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.