Evidence map›Paper›PMID 35505016›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2022

In Vivo Models for Studying Interstitial Photodynamic Therapy of Locally Advanced Cancer.

Gal Shafirstein, Emily Oakley, Sasheen Hamilton, Michael Habitzruther, Sarah Chamberlain, Sandra Sexton, Leslie Curtin, David A Bellnier

Open access · greenAbstract read
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
7.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Light as a Weapon: Redefining Cancer Care with Photodynamic Therapy.International journal of biological sciences · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Gal ShafirsteinPhotodynamic Therapy Center at the Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center (Roswell Park), Buffalo, NY, USA. Gal.Shafirstein@RoswellPark.org.
Emily OakleyPhotodynamic Therapy Center at the Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center (Roswell Park), Buffalo, NY, USA.
Sasheen HamiltonPhotodynamic Therapy Center at the Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center (Roswell Park), Buffalo, NY, USA.
Michael HabitzrutherPhotodynamic Therapy Center at the Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center (Roswell Park), Buffalo, NY, USA.
Sarah ChamberlainPhotodynamic Therapy Center at the Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center (Roswell Park), Buffalo, NY, USA.
Sandra SextonLaboratory Animals Shared Resources, Roswell Park, Buffalo, NY, USA.
Leslie CurtinLaboratory Animals Shared Resources, Roswell Park, Buffalo, NY, USA.
David A BellnierPhotodynamic Therapy Center at the Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center (Roswell Park), Buffalo, NY, USA.
Roswell Park Comprehensive Cancer Center · US

Funding

Two-Spirit Films in Indigenous Cancer HealthP30CA016056 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI Dean G. Tang · 1985 to 2026
$116.6M
Integrated Image-guided Dosimetry & Treatment Planning PDTR01CA193610 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI SHAFIRSTEIN, GAL · 2016 to 2020
$2.5M
NCI NIH HHS P30 CA016056NCI NIH HHS R01 CA193610
6 · The paper itself

Abstract

Interstitial photodynamic therapy (I-PDT) is a promising therapy considered for patients with locally advanced cancer. In I-PDT, laser fibers are inserted into the tumor for effective illumination and activation of the photosensitizer in a large tumor. The intratumoral light irradiance and fluence are critical parameters that affect the response to I-PDT. In vivo animal models are required to conduct light dose studies, to define optimal irradiance and fluence for I-PDT. Here we describe two animal models with locally advanced tumors that can be used to evaluate the response to I-PDT. One model is the C3H mouse bearing large subcutaneous SCCVII carcinoma (400-600 mm

Indexed as

CarcinomaNeoplasms, Second PrimaryPhotochemotherapyAnimalsHumansMiceMice, Inbred C3HPhotosensitizing AgentsRabbitsPhotosensitizing AgentsInterstitial photodynamic therapyLocally advanced cancerSCCVIIVX2 carcinoma

Identifiers

PMID35505016
PMCPMC9904013
OpenAlexW4285189096

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.