ArticleCellular and molecular life sciences : CMLS2022
GHSR controls food deprivation-induced activation of CRF neurons of the hypothalamic paraventricular nucleus in a LEAP2-dependent manner.
Open access · bronzeAbstract read
In one paragraph
Article in Cellular and molecular life sciences : CMLS, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- LEAP2 Reduces Ad Libitum Food Intake and Attenuates Postprandial Glucose Excursions in Men With Obesity.Diabetes · 2026Trial
- Plasma LEAP-2 Following a Low-Calorie Diet with or without Interval Exercise in Women with Obesity.Nutrients · 2023Trial
- The Ghrelin-LEAP2 System in Obesity and Diabetes: Pathophysiological Roles and Therapeutic Potential.Current obesity reports · 2026Review
- LEAP2 as a therapeutic target in obesity and cardiometabolic disorders.Reviews in endocrine & metabolic disorders · 2026Review
- The role of LEAP2 on cognitive impulsivity after refeeding: evidence from a preclinical study in female mice and from patients with anorexia nervosa.Translational psychiatry · 2026Article
- Differential effects of overexpression of mutant huntingtin and TDP-43 in agouti-related protein neurons in the arcuate nucleus of the hypothalamus in mice.Acta neuropathologica communications · 2025Article
- AgRP neuron activity enhances reward-related consummatory behaviors during energy deficit in mice.Communications biology · 2025Article
- Plasma LEAP2 concentration is associated with energy intake and postprandial insulin increase depending on meal size but not weight status in men.Diabetes, obesity & metabolism · 2025Article
- Peptide with Dual Roles in Immune and Metabolic Regulation: Liver-Expressed Antimicrobial Peptide-2 (LEAP-2).Molecules (Basel, Switzerland) · 2025Review
- LEAP2 in Physiology-A Narrative Review.International journal of molecular sciences · 2025Review
- Brain-acting hepatokines: its impact on energy balance and metabolism.Frontiers in neuroscience · 2025Review
- An Emerging Role for Gut-Brain Signaling Involving Ghrelin in Chronic Stress.Advances in experimental medicine and biology · 2025Review
- Satiety Hormone LEAP2 After Low-Calorie Diet With/Without Endobarrier Insertion in Obesity and Type 2 Diabetes Mellitus.Journal of the Endocrine Society · 2024Article
- Molecular and functional mapping of the neuroendocrine hypothalamus: a new era begins.Journal of endocrinological investigation · 2024Review
- Pre-prandial plasma liver-expressed antimicrobial peptide 2 (LEAP2) concentration in humans is inversely associated with hunger sensation in a ghrelin independent manner.European journal of nutrition · 2024Article
- Ghrelin Action in the PVH of Male Mice: Accessibility, Neuronal Targets, and CRH Neurons Activation.Endocrinology · 2023Article
- Postprandial Increases in Liver-Gut Hormone LEAP2 Correlate with Attenuated Eating Behavior in Adults Without Obesity.Journal of the Endocrine Society · 2023Article
- Involvement of POMC neurons in LEAP2 regulation of food intake and body weight.Frontiers in endocrinology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 4 institutions in 4 countries.
Gimena FernandezLaboratory of Neurophysiology, Multidisciplinary Institute of Cell Biology [IMBICE, Argentine Research Council (CONICET) and Scientific Research Commission, Province of Buenos Aires (CIC-PBA), National University of La Plata (UNLP)], Calle 526 S/N entre 10 y 11, La Plata, Buenos Aires, 1900, Argentina.ORCID http://orcid.org/0000-0003-2742-157X
Agustina CabralLaboratory of Neurophysiology, Multidisciplinary Institute of Cell Biology [IMBICE, Argentine Research Council (CONICET) and Scientific Research Commission, Province of Buenos Aires (CIC-PBA), National University of La Plata (UNLP)], Calle 526 S/N entre 10 y 11, La Plata, Buenos Aires, 1900, Argentina.
Pablo N De FrancescoLaboratory of Neurophysiology, Multidisciplinary Institute of Cell Biology [IMBICE, Argentine Research Council (CONICET) and Scientific Research Commission, Province of Buenos Aires (CIC-PBA), National University of La Plata (UNLP)], Calle 526 S/N entre 10 y 11, La Plata, Buenos Aires, 1900, Argentina.
Maia UriarteLaboratory of Neurophysiology, Multidisciplinary Institute of Cell Biology [IMBICE, Argentine Research Council (CONICET) and Scientific Research Commission, Province of Buenos Aires (CIC-PBA), National University of La Plata (UNLP)], Calle 526 S/N entre 10 y 11, La Plata, Buenos Aires, 1900, Argentina.
Mirta ReynaldoLaboratory of Neurophysiology, Multidisciplinary Institute of Cell Biology [IMBICE, Argentine Research Council (CONICET) and Scientific Research Commission, Province of Buenos Aires (CIC-PBA), National University of La Plata (UNLP)], Calle 526 S/N entre 10 y 11, La Plata, Buenos Aires, 1900, Argentina.
Daniel CastrogiovanniCell Culture Facility, Multidisciplinary Institute of Cell Biology [IMBICE, Argentine Research Council (CONICET) and Scientific Research Commission, Province of Buenos Aires (CIC-PBA), National University of La Plata (UNLP)], Calle 526 S/N entre 10 y 11, La Plata, Buenos Aires, 1900, Argentina.
Guillermina ZubiríaLaboratory of Neuroendocrinology, Multidisciplinary Institute of Cell Biology [IMBICE, Argentine Research Council (CONICET) and Scientific Research Commission, Province of Buenos Aires (CIC-PBA), National University of La Plata (UNLP)], Calle 526 S/N entre 10 y 11, La Plata, Buenos Aires, 1900, Argentina.
Andrés GiovambattistaLaboratory of Neuroendocrinology, Multidisciplinary Institute of Cell Biology [IMBICE, Argentine Research Council (CONICET) and Scientific Research Commission, Province of Buenos Aires (CIC-PBA), National University of La Plata (UNLP)], Calle 526 S/N entre 10 y 11, La Plata, Buenos Aires, 1900, Argentina.
Sonia CantelInstitut Des Biomolécules Max Mousseron, UMR 5247 CNRS-Université Montpellier-ENSCM, Montpellier, France.
Severine DenoyelleInstitut Des Biomolécules Max Mousseron, UMR 5247 CNRS-Université Montpellier-ENSCM, Montpellier, France.
Jean-Alain FehrentzInstitut Des Biomolécules Max Mousseron, UMR 5247 CNRS-Université Montpellier-ENSCM, Montpellier, France.
Virginie TolleInstitute of Psychiatry and Neuroscience of Paris, Université de Paris, UMR-S 1266 INSERM, Paris, France.
Helgi B SchiöthDepartment of Surgical Sciences, Functional Pharmacology and Neuroscience, Uppsala University, Uppsala, Sweden.
Mario PerelloLaboratory of Neurophysiology, Multidisciplinary Institute of Cell Biology [IMBICE, Argentine Research Council (CONICET) and Scientific Research Commission, Province of Buenos Aires (CIC-PBA), National University of La Plata (UNLP)], Calle 526 S/N entre 10 y 11, La Plata, Buenos Aires, 1900, Argentina. mperello@imbice.gov.ar.
Instituto Multidisciplinario de Biología Celular · ARÉcole Nationale Supérieure de Chimie de Montpellier · FRUppsala University · SEInserm · FR
Funding
Conicet PUE105Fondo para la Investigación Científica y Tecnológica PICT2016-1084Fondo para la Investigación Científica y Tecnológica PICT2017-3196Fondo para la Investigación Científica y Tecnológica PICT2019-3054The National Qatar Research Foundation NPRP13S-0209-200315
Abstract
objectiveProlonged fasting is a major challenge for living organisms. An appropriate metabolic response to food deprivation requires the activation of the corticotropin-releasing factor-producing neurons of the hypothalamic paraventricular nucleus (PVH
methodsWe estimated the activation of the PVH
resultsWe found that food deprivation results in the activation of the PVH
conclusionFood deprivation-induced activation of the PVH
Indexed as
Food DeprivationParaventricular Hypothalamic NucleusAnimalsAntimicrobial Cationic PeptidesCorticotropin-Releasing HormoneEatingGhrelinHypothalamo-Hypophyseal SystemMaleMiceNeuronsPituitary-Adrenal SystemReceptors, GhrelinAntimicrobial Cationic PeptidesCorticotropin-Releasing HormoneGhrelinGhsr protein, MouseLeap2 protein, mouseReceptors, GhrelinConstitutive GHSR activityCRH neuronsGhrelin
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.