Evidence map›Paper›PMID 35504979›Full record

ArticleArchives of toxicology2022

Salivary nitrate/nitrite and acetaldehyde in humans: potential combination effects in the upper gastrointestinal tract and possible consequences for the in vivo formation of N-nitroso compounds-a hypothesis.

Gerhard Eisenbrand, Matthias Baum, Alexander T Cartus, Patrick Diel, Karl-Heinz Engel, Barbara Engeli, Bernd Epe, Tilman Grune, Sabine Guth, Dirk Haller and 21 more

Abstract readEditorial
PubMed Publisher
In one paragraph

Article in Archives of toxicology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors at 20 institutions in 4 countries.

Gerhard Eisenbrand, Kühler Grund 48/1, 69126, Heidelberg, Germany. geisenbra@gmail.com.
Matthias BaumSolenis Germany Industries GmbH, Fütingsweg 20, 47805, Krefeld, Germany.
Alexander T CartusChemservice S.A., 13, Fausermillen, 6689, Mertert, Luxembourg.
Patrick DielDepartment of Molecular and Cellular Sports Medicine, Institute of Cardiovascular Research and Sports Medicine, German Sport University Cologne, Am Sportpark Müngersdorf 6, 50933, Cologne, Germany.
Karl-Heinz EngelChair of General Food Technology, Technical University of Munich, Maximus-von-Imhof-Forum 2, 85354, Freising, Germany.
Barbara EngeliRisk Assessment Division, Federal Food Safety and Veterinary Office (FSVO), Schwarzenburgstrasse 155, 3003, Bern, Switzerland.
Bernd EpeInstitute of Pharmaceutical and Biomedical Sciences, University of Mainz, Staudinger Weg 5, 55128, Mainz, Germany.
Tilman GruneDepartment of Molecular Toxicology, German Institute of Human Nutrition (DIfE), Arthur-Scheunert-Allee 114-116, 14558, Nuthetal, Germany.
Sabine GuthLeibniz Research Centre for Working Environment and Human Factors (IfADo), Ardeystr. 67, 44139, Dortmund, Germany.ORCID http://orcid.org/0000-0002-5729-0331
Dirk HallerZIEL, Institute for Food and Health, Technical University of Munich, 85354, Freising, Germany.
Volker HeinzGerman Institute of Food Technologies (DIL), Prof.-von-Klitzing-Str. 7, 49610, Quakenbrück, Germany.
Michael HellwigInstitute of Food Chemistry, Technical University of Braunschweig, Schleinitzstr. 20, 38106, Braunschweig, Germany.
Jan G HengstlerLeibniz Research Centre for Working Environment and Human Factors (IfADo), Ardeystr. 67, 44139, Dortmund, Germany.
Thomas HenleDepartment of Food Chemistry, TU Dresden, Bergstrasse 66, 01069, Dresden, Germany.
Hans-Ulrich HumpfInstitute of Food Chemistry, Westfälische Wilhelms-Universität Münster, Corrensstraße 45, 48149, Münster, Germany.
Henry JägerInstitute of Food Technology, University of Natural Resources and Life Sciences (BOKU), Muthgasse 18, 1190, Vienna, Austria.
Hans-Georg JoostDepartment of Experimental Diabetology, German Institute of Human Nutrition (DIfE), Arthur-Scheunert-Allee 114-116, 14558, Nuthetal, Germany.
Sabine KullingDepartment of Safety and Quality of Fruit and Vegetables, Federal Research Institute of Nutrition and Food, Max Rubner-Institut, Haid-und-Neu-Straße 9, 76131, Karlsruhe, Germany.
Dirk W LachenmeierChemisches und Veterinäruntersuchungsamt Karlsruhe, Weißenburger Straße 3, 76187, Karlsruhe, Germany.
Alfonso LampenRisk Assessment Strategies, Bundesinstitut für Risikobewertung (BfR), Max-Dohrn-Straße 8-10, Berlin, Germany.
Marcel LeistIn Vitro Toxicology and Biomedicine, Department Inaugurated by the Doerenkamp-Zbinden Foundation, University of Konstanz, Box 657, 78457, Konstanz, Germany.
Angela MallyDepartment of Toxicology, University of Würzburg, Versbacher Str. 9, 97078, Würzburg, Germany.
Doris MarkoDepartment of Food Chemistry and Toxicology, Faculty of Chemistry, University of Vienna, Währinger Straße 38, 1090, Vienna, Austria.
Ute NöthlingsDepartment of Nutrition and Food Sciences, Nutritional Epidemiology, Rheinische Friedrich-Wilhelms University Bonn, Friedrich-Hirzebruch-Allee 7, 53115, Bonn, Germany.
Elke RöhrdanzUnit Reproductive and Genetic Toxicology, Federal Institute for Drugs and Medical Devices (BfArM), Kurt-Georg-Kiesinger Allee 3, 53175, Bonn, Germany.
Angelika RothLeibniz Research Centre for Working Environment and Human Factors (IfADo), Ardeystr. 67, 44139, Dortmund, Germany.
Joachim SprangerDepartment of Endocrinology and Metabolic Medicine, Campus Benjamin Franklin, Charité University Medicine, Hindenburgdamm 30, 12203, Berlin, Germany.
Richard StadlerInstitute of Food Safety and Analytic Sciences, Nestlé Research Centre, Route du Jorat 57, 1000, Lausanne 26, Switzerland.
Stefan ViethsFederal Institute for Vaccines and Biomedicines, Paul-Ehrlich-Institut, Paul-Ehrlich-Straße 51-59, 63225, Langen, Germany.
Wim WätjenInstitut für Agrar- und Ernährungswissenschaften, Martin-Luther-Universität Halle-Wittenberg, Weinbergweg 22, 06120, Halle (Saale), Germany.
Pablo SteinbergFederal Research Institute of Nutrition and Food, Max Rubner-Institut, Haid-und-Neu-Straße 9, 76131, Karlsruhe, Germany. pablo.steinberg@mri.bund.de.
TU Dortmund University · DEGerman Institute of Human Nutrition · DEMax Rubner Institut · DEBOKU University · ATBühler (United Kingdom) · GBCharité - Universitätsmedizin Berlin · DEChemisches und Veterinäruntersuchungsamt Karlsruhe · DEFederal Food Safety and Veterinary Office · CHFederal Institute for Drugs and Medical Devices · DEFederal Institute for Risk Assessment · DEGerman Institute of Food Technologies · DEGerman Sport University Cologne · DEJohannes Gutenberg University Mainz · DELeibniz-Institute for Food Systems Biology at the Technical University of Munich · DEMartin Luther University Halle-Wittenberg · DENestlé (Switzerland) · CHPaul Ehrlich Institut · DETechnical University of Munich · DETechnische Universität Braunschweig · DETechnische Universität Dresden · DE

Funding

Deutsche Forschungsgemeinschaft HE 2509/15-11
6 · The paper itself

Abstract

Subsequent to the dietary uptake of nitrate/nitrite in combination with acetaldehyde/ethanol, combination effects resulting from the sustained endogenous exposure to nitrite and acetaldehyde may be expected. This may imply locoregional effects in the upper gastrointestinal tract as well as systemic effects, such as a potential influence on endogenous formation of N-nitroso compounds (NOC). Salivary concentrations of the individual components nitrate and nitrite and acetaldehyde are known to rise after ingestion, absorption and systemic distribution, thereby reflecting their respective plasma kinetics and parallel secretion through the salivary glands as well as the microbial/enzymatic metabolism in the oral cavity. Salivary excretion may also occur with certain drug molecules and food constituents and their metabolites. Therefore, putative combination effects in the oral cavity and the upper digestive tract may occur, but this has remained largely unexplored up to now. In this Guest Editorial, published evidence on exposure levels and biokinetics of nitrate/nitrite/NO

Indexed as

NitritesUpper Gastrointestinal TractAcetaldehydeHumansNitratesNitroso CompoundsSalivaAcetaldehydeNitratesNitritesNitroso CompoundsAcetaldehydeCombination effectsNitrateNitriteN-nitroso compoundsUpper gastrointestinal tract

Identifiers

PMID35504979
OpenAlexW4225417721

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.