Evidence map›Paper›PMID 35504958›Full record

ArticleModern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc2022

Immunohistochemical loss of enhancer of Zeste Homolog 2 (EZH2) protein expression correlates with EZH2 alterations and portends a worse outcome in myelodysplastic syndromes.

Ali Sakhdari, Caleb Class, Guillermo Montalban-Bravo, Koji Sasaki, Carlos E Bueso-Ramos, Keyur P Patel, Mark J Routbort, Sanam Loghavi, Chi Young Ok, Andres Quesada and 6 more

Abstract read
In one paragraph

Article in Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Therapeutic Advances in Immunotherapies for Hematological Malignancies.International journal of molecular sciences · 2022
    Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

Ali SakhdariDepartment of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0002-4610-7562
Caleb ClassDepartment of Biostatistics, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
Guillermo Montalban-BravoDepartment of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
Koji SasakiDepartment of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
Carlos E Bueso-RamosDepartment of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
Keyur P PatelDepartment of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0001-5081-2427
Mark J RoutbortDepartment of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0003-4860-261X
Sanam LoghaviDepartment of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0001-8980-3202
Chi Young OkDepartment of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0002-6822-7880
Andres QuesadaDepartment of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
Joseph D KhouryDepartment of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0003-2621-3584
Sergej N KonoplevDepartment of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
Hagop P KantarjianDepartment of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
Guillermo Garcia-ManeroDepartment of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0002-3631-2482
L Jeffrey MedeirosDepartment of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0001-6577-8006
Rashmi Kanagal-ShamannaDepartment of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA. RKanagal@mdanderson.org.ORCID 0000-0001-7829-5249
The University of Texas MD Anderson Cancer Center · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8M
NCI NIH HHS P30 CA016672
6 · The paper itself

Abstract

EZH2 coding mutation (EZH2

Indexed as

Enhancer of Zeste Homolog 2 ProteinMyelodysplastic SyndromesAgedAged, 80 and overFemaleHumansMaleMiddle AgedMutationPrognosisTranscription FactorsEnhancer of Zeste Homolog 2 ProteinEZH2 protein, humanTranscription Factors

Identifiers

PMID35504958
PMCPMC13105204
OpenAlexW4225306340

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.