ArticleScientific reports2022
High-sensitivity C-reactive protein could be a potential indicator of bone mineral density in adolescents aged 10-20 years.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- A novel perspective on adolescent bone health: the role of C-reactive protein-triglyceride-glucose index.Pediatric research · 2026Article
- Association between lymphocyte to high-density lipoprotein ratio and total bone mineral density in 8-19-year-old children and adolescents: a cross-sectional study.European journal of medical research · 2026Article
- Clinical Significance of the C-Reactive Protein-Triglyceride-Glucose Index in Cardiovascular Disease, Stroke, Cardiovascular-Kidney-Metabolic Syndrome, Cancer, Diabetes, and Osteoporosis: A Narrative Review.International journal of general medicine · 2026Review
- The study findings demonstrated a significant association between C-reactive protein levels and trabecular bone score : NHANES 2005-2008.Journal of orthopaedic surgery and research · 2024Article
- C-Reactive Protein: Pathophysiology, Diagnosis, False Test Results and a Novel Diagnostic Algorithm for Clinicians.Diseases (Basel, Switzerland) · 2023Review
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Authors and funding
4 authors.
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Abstract
There was very limited evidence linking high-sensitivity C-reactive protein (HS-CRP) and total bone mineral density (BMD) in adolescents. The aim of this population-based study was to investigate the relationship between HS-CRP and total BMD in adolescents aged 10-20 years. A cross-sectional study was performed in the normal U.S. population from the data of the National Health and Nutrition Examination Survey (NHANES). The correlation between HS-CRP and total BMD was evaluated by using weighted multivariate linear regression models. And further subgroup analysis was conducted. There were 1747 participants in this study, 47.1% were female, 29.4% were white, 19.5% were black, and 22.3% were Mexican-American. In the multi-regression model that after the potential confounders had been adjusted, HS-CRP was negatively associated with total BMD. The negative association was also observed in the subgroup analyses stratified by gender and age. Our results demonstrated that higher HS-CRP was negatively correlated with total BMD in 10-20 years old adolescents.
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