Evidence map›Paper›PMID 35504933›Full record

ArticleScientific reports2022

Association between circulating CD34-positive cell count and height loss among older men.

Yuji Shimizu, Shin-Ya Kawashiri, Kenichi Nobusue, Fumiaki Nonaka, Mami Tamai, Yukiko Honda, Hirotomo Yamanashi, Seiko Nakamichi, Masahiko Kiyama, Naomi Hayashida and 2 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Yuji ShimizuDepartment of General Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan. shimizu@osaka-ganjun.jp.
Shin-Ya KawashiriDepartment of Community Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Kenichi NobusueDepartment of Islands and Community Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Fumiaki NonakaDepartment of Islands and Community Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Mami TamaiLeading Medical Research Core Unit, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Yukiko HondaDepartment of Community Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Hirotomo YamanashiDepartment of General Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Seiko NakamichiDepartment of General Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Masahiko KiyamaDepartment of Cardiovascular Disease Prevention, Osaka Center for Cancer and Cardiovascular Diseases Prevention, Osaka, Japan.
Naomi HayashidaLeading Medical Research Core Unit, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Yasuhiro NagataDepartment of Community Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Takahiro MaedaDepartment of General Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Nagasaki University · JPOsaka Medical Center for Cancer and Cardiovascular Diseases · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Height loss starting in middle age is reportedly significantly associated with death due to cardiovascular disease. Impaired blood flow is the main pathology in cardiovascular disease. Hematopoietic stem cells such as CD34-positive cells play an important role in maintaining the microcirculation and preventing impaired blood flow by activating endothelial repair and angiogenesis. Therefore, circulating CD34-positive cell count could be associated with height loss. To clarify the association between circulating CD34-positive cell count and height loss, we conducted a follow-up study of 363 Japanese men aged 60-69 years over 2 years. Height loss was defined as being in the highest quartile of height decrease per year. Independent of known cardiovascular risk factors, circulating CD34-positive cell count was significantly inversely associated with height loss. The fully adjusted odds ratio (OR) and 95% confidence interval (CI) of height loss for circulating CD34-positive cell count (logarithmic values) was 0.49 (0.32, 0.74). This study suggests that a lower capacity to maintain the microcirculation due to a fewer CD34-positive cells might affect height loss.

Indexed as

Cardiovascular DiseasesAgedAntigens, CD34Cell CountCross-Sectional StudiesFollow-Up StudiesHumansMaleMiddle AgedRisk FactorsAntigens, CD34

Identifiers

PMID35504933
PMCPMC9064966
OpenAlexW4225312723

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.