ArticleNature communications2022
DNA methylation signature of chronic low-grade inflammation and its role in cardio-respiratory diseases.
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In one paragraph
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
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90citing papers in PubMed, 3 pooled it
10.0field-weighted citation impact, top 1% of its field
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
90 citing papers in PubMed, 3 syntheses or guidelines pooled it, 126 citations in OpenAlex.
- Epigenome-wide association study of circulating interleukin-6 connects DNA methylation to immunometabolic and inflammatory health.Communications biology · 2026Pooled it
- DNA methylation of genes involved in lipid metabolism drives adiponectin levels and metabolic disease.Diabetologia · 2026Pooled it
- Epigenome-wide association studies identify novel DNA methylation sites associated with PTSD: a meta-analysis of 23 military and civilian cohorts.Genome medicine · 2024Pooled it
- Telehealth Parenting Program and Salivary Epigenetic Biomarkers in Preschool Children With Developmental Delay: NIMHD Social Epigenomics Program.JAMA network open · 2024Trial
- DNA methylation-based surrogate markers of C-reactive protein and their associations with health-related traits.GeroScience · 2026Article
- Longitudinal Changes in Inflammation-Related Methylation Risk Score for C-Reactive Protein Among People with HIV.Epigenomes · 2026Article
- Epigenetic age acceleration and metabolic syndrome among Hispanic/Latino adults: Hispanic Community Health Study/Study of Latinos (HCHS/SOL).International journal of obesity (2005) · 2026Article
- The OmniAge compendium of aging omic biomarkers links mitotic clocks to clonal hematopoiesis and causality.Nature communications · 2026Article
- Interpersonal stress, epigenetic indices of inflammation, and depressive symptoms: Longitudinal associations from adolescence to young adulthood.Neurobiology of stress · 2026Article
- Immune aging biomarkers for clinical trials.Nature medicine · 2026Review
- Accelerated Epigenetic and Inflammatory Aging and Intrinsic Capacity.JAMA network open · 2026Article
- Strong concordance of DNA methylation measures between venous and capillary blood - Implications for human epigenome studies.iScience · 2026Article
- DNA methylation signatures of inflammation in youth living with perinatally-acquired HIV.Clinical epigenetics · 2026Article
- CpG Atlas: A centralized multi-layer database and AI interface for DNA methylation research.bioRxiv : the preprint server for biology · 2026Article
- Simultaneous Assessment of Genetic and Epigenetic Contributions to the Plasma Lipid Levels with Respect to Cardiovascular Risk.Journal of atherosclerosis and thrombosis · 2026Article
- Regulator of G protein signaling 10: a critical regulator of chronic systemic inflammation in parkinson's disease.Journal of neuroinflammation · 2026Review
- Cancer Treatment-Related Cardiotoxicity among Survivors of Childhood Cancer: A Comparative and Integrated View of Multiple Measures of Biological Age Acceleration.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2026Article
- Epigenetic inflammation signatures and lung cancer risk among never-smoking women: a nested case-control study.medRxiv : the preprint server for health sciences · 2026Article
- Physical Fitness Is Negatively Associated With DNA Methylation-Based Risk of Aging-Related Diseases.Aging cell · 2026Article
- State-Dependent DNA Methylation Signatures Distinguish Acute from Stable Coronary Syndromes.International journal of molecular sciences · 2026Article
30 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
90 authors at 20 institutions in 12 countries.
Matthias WielscherDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK. matthias.wielscher@meduniwien.ac.at.ORCID 0000-0003-4138-1383
Pooja R MandaviyaDepartment of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.
Brigitte KuehnelResearch Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Bavaria, Germany.
Roby JoehanesFramingham Heart Study, Framingham, MA, USA.
Rima MustafaDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.ORCID 0000-0003-2623-5337
Oliver RobinsonDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.ORCID 0000-0002-4735-0468
Yan ZhangDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany.
Barbara BodinierDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.ORCID 0000-0002-0781-3624
Esther WaltonDepartment of Psychology, University of Bath, Bath, UK.ORCID 0000-0002-0935-2200
Pashupati P MishraDepartment of Clinical Chemistry, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Pascal SchlosserInstitute of Genetic Epidemiology, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany.ORCID 0000-0002-8460-0462
Rory WilsonResearch Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Bavaria, Germany.ORCID 0000-0001-6135-3764
Pei-Chien TsaiDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Saranya PalaniswamyDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.ORCID 0000-0003-4145-540X
Riccardo E MarioniCentre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, UK.
Giovanni FioritoLaboratory of Biostatistics, Department of Biomedical Sciences, University of Sassari, Sassari, Italy.
Giovanni CugliariFondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
Ville KarhunenDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.ORCID 0000-0001-6064-1588
Mohsen GhanbariDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.ORCID 0000-0002-9476-7143
Bruce M PsatyCardiovacular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.ORCID 0000-0002-7278-2190
Marie LohDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.ORCID 0000-0003-3626-8466
Joshua C BisCardiovascular Health Research Unit, Division of Cardiology, University of Washington, Seattle, WA, USA.ORCID 0000-0002-3409-1110
Benjamin LehneDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
Nona SotoodehniaCardiovascular Health Research Unit, Division of Cardiology, University of Washington, Seattle, WA, USA.
Ian J DearyLothian Birth Cohorts, Department of Psychology, University of Edinburgh, Edinburgh, UK.
Marc Chadeau-HyamDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.ORCID 0000-0001-8341-5436
Jennifer A BrodyCardiovascular Health Research Unit, Division of Cardiology, University of Washington, Seattle, WA, USA.ORCID 0000-0001-8509-148X
Alexia CardonaMRC Epidemiology Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK.ORCID 0000-0002-7877-5565
Elizabeth SelvinDept. of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Alicia K SmithDepartments of Gynecology and Obstetrics & Psychiatry and Behavioral Science, Emory University School of Medicine, Atlanta, GA, USA.ORCID 0000-0002-8537-5156
Andrew H MillerDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia.ORCID 0000-0001-8260-7997
Mylin A TorresDepartment of Radiation Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA.
Eirini MarouliWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.ORCID 0000-0001-6179-1609
Xin GàoDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany.ORCID 0000-0003-0108-6961
Joyce B J van MeursDepartment of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.
Johanna Graf-SchindlerResearch Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Bavaria, Germany.
Wolfgang RathmannInstitute for Biometrics and Epidemiology, German Diabetes Center, Leibniz Center for Diabetes Resesarch at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Wolfgang KoenigDeutsches Herzzentrum München, Technische Universität München, Munich, Germany.ORCID 0000-0002-2064-9603
Annette PetersResearch Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Bavaria, Germany.ORCID 0000-0001-6645-0985
Wolfgang WeningerDepartment of Dermatology, Medical University of Vienna, Vienna, Austria.
Matthias FarlikDepartment of Dermatology, Medical University of Vienna, Vienna, Austria.ORCID 0000-0003-0698-2992
Tao ZhangDeptarment of Biostatistics, School of Public Health, Shandong University, Jinan, China.
Wei ChenDepartment of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA.ORCID 0000-0003-1566-7943
Yujing XiaDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.ORCID 0000-0003-0850-5591
Alexander TeumerInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.ORCID 0000-0002-8309-094X
Matthias NauckDZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany.ORCID 0000-0002-6678-7964
Hans J GrabeDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.
Macus DoerrDZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany.ORCID 0000-0001-7471-475X
Terho LehtimäkiDepartment of Clinical Chemistry, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.ORCID 0000-0002-2555-4427
Weihua GuanDivision of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
Lili MilaniEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID 0000-0002-5323-3102
Toshiko TanakaTranslational Gerontology Branch, Biomedical Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Krista FisherEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID 0000-0002-3521-0599
Lindsay L WaiteHudsonAlpha Institute for Biotechnology, Huntsville, AL, USA.
Silva KaselaEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Paolo VineisDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
Niek VerweijDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, Groningen, The Netherlands.
Pim van der HarstDepartment of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands.ORCID 0000-0002-2713-686X
Licia IacovielloDepartment of Epidemiology and Prevention, IRCCS NEUROMED, Pozzilli, IS, Italy.
Carlotta SacerdoteUnit of Cancer Epidemiology, Citta' della Salute e della Scienza Hospital and Centre for Cancer Prevention, Turin, Italy.
Salvatore PanicoDipartimento di Medicina Clinica e Chirurgia Federico II University, Naples, Italy.
Vittorio KroghEpidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.ORCID 0000-0003-0122-8624
Rosario TuminoCancer Registry and Histopathology Department, "Civic - MPP Arezzo" Hospital, ASP Ragusa, Ragusa, Italy.
Evangelia TzalaDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
Giuseppe MatulloDepartment of Medical Sciences, University of Turin, Turin, Italy.
Mikko A HurmeFaculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Olli T RaitakariResearch centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
Elena ColicinoDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Andrea A BaccarelliLaboratory of Environmental Epigenetics, Departments of Environmental Health Sciences and Epidemiology, Columbia University Mailman School of Public Health, New York, NY, USA.
Mika KähönenFinnish Cardiovascular Research Centre, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Karl-Heinz HerzigResearch Unit of Biomedicine, Medical Research Center, Faculty of Medicine, University of Oulu, and Oulu University Hospital, Oulu, Finland.ORCID 0000-0003-4460-2604
Shengxu LiChildren's Minnesota Research Institute, Children's Minnesota, Minneapolis, MN, USA.ORCID 0000-0001-9210-7283
BIOS consortium
Karen N ConneelyDepartment of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA.
Jaspal S KoonerNational Heart and Lung Institute, Imperial College London, London, UK.
Anna KöttgenInstitute of Genetic Epidemiology, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany.ORCID 0000-0002-4671-3714
Bastiaan T HeijmansMolecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0001-5918-0534
Panos DeloukasWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.ORCID 0000-0001-9251-070X
Caroline ReltonMedical Research Council Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol, UK.
Ken K OngMRC Epidemiology Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK.ORCID 0000-0003-4689-7530
Jordana T BellDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.ORCID 0000-0002-3858-5986
Eric BoerwinkleHuman Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA.
Paul ElliottDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.ORCID 0000-0002-7511-5684
Hermann BrennerDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany.ORCID 0000-0002-6129-1572
Marian BeekmanDepartment of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0003-0585-6206
Daniel LevyFramingham Heart Study, Framingham, MA, USA.
Melanie WaldenbergerResearch Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Bavaria, Germany.ORCID 0000-0003-0583-5093
John C ChambersDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.ORCID 0000-0003-0209-4541
Abbas DehghanDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.ORCID 0000-0001-6403-016X
Marjo-Riitta JärvelinDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK. m.jarvelin@imperial.ac.uk.ORCID 0000-0002-2149-0630
Imperial College London · GBHelmholtz Zentrum München · DEEmory University · USTampere University · FIUniversitätsmedizin Greifswald · DEUniversity of Washington · USGerman Cancer Research Center · DENational Institutes of Health · USUniversity of Tartu · EEEaling Hospital · GBErasmus MC · NLFondazione IRCCS Istituto Nazionale dei Tumori · ITJohns Hopkins University · USKing's College London · GBLeiden University Medical Center · NLMedical University of Vienna · ATQueen Mary University of London · GBUniversity of Bristol · GBUniversity of Cambridge · GBAzienda Ospedaliera Citta' della Salute e della Scienza di Torino · IT
Funding
UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1MInstitute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8MUCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0MBuilding on GWAS for NHLBI-disease: the CHARGE consortiumRC2HL102419 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BOERWINKLE, ERIC A. · 2009 to 2010
$27.6MGenome-Wide Association Analysis in Essential Hypertension (FEHGAS study)R01HL086694 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ARAVINDA CHAKRAVARTI · 2007 to 2026
$21.2MEpidemiology of Venous Thrombosis & Pulmonary EmbolismR01HL059367 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI TANG, WEIHONG · 1998 to 2024
$11.8MExceptional Survival: Trajectories to Functional Aging (CHS All Stars)R01AG023629 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NEWMAN, ANNE B. · 2004 to 2016
$9.5MCHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5MRare variants and NHLBI traits in deeply phenotyped cohortsR01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2014 to 2016
$8.9MCARDIOVASCULAR HEALTH STUDY (CHS) - TASK AREA C, STUDY CLOSEOUT75N92021D00006 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE · 2021 to 2024
$8.4MCHS research resources for the cardiovascular health of older adultsU01HL130114 · NHLBI · UNIVERSITY OF WASHINGTON · PI BURKE, GREGORY L, KRONMAL, RICHARD A · 2016 to 2019
$6.6MProspective meta-analyses of drug-gene interactions: CHARGE GWAS consortiumR01HL103612 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M · 2011 to 2014
$5.4MBiotechnology and Biological Sciences Research Council BB/I025263/1Biotechnology and Biological Sciences Research Council BBI025751/1Biotechnology and Biological Sciences Research Council BB/S020845/1Biotechnology and Biological Sciences Research Council BB/T019980/1British Heart Foundation RE/18/4/34215British Heart Foundation RG/14/5/30893Department of Health 16/136/68Medical Research Council G0601653Medical Research Council G1001357Medical Research Council MC_UU_00006/2Medical Research Council MC_UU_00011/5Medical Research Council MR/K026992/1Medical Research Council MR/L01632X/1Medical Research Council MR/M01311/1Medical Research Council MR/R023484/1Medical Research Council MR/S019669/1Medical Research Council MR/S03532X/1NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1 TR001881NCRR NIH HHS UL1 RR025005NHGRI NIH HHS U01 HG004402NHLBI NIH HHS 75N92021D00006NHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS HHSN268201700001INHLBI NIH HHS HHSN268201700002INHLBI NIH HHS HHSN268201700003INHLBI NIH HHS HHSN268201700004INHLBI NIH HHS HHSN268201700005INHLBI NIH HHS HHSN268201800001CNHLBI NIH HHS K08 HL116640NHLBI NIH HHS N01HC55222NHLBI NIH HHS N01HC85079NHLBI NIH HHS N01HC85080NHLBI NIH HHS N01HC85081NHLBI NIH HHS N01HC85082NHLBI NIH HHS N01HC85083NHLBI NIH HHS N01HC85086NHLBI NIH HHS R01 HL059367NHLBI NIH HHS R01 HL086694NHLBI NIH HHS R01 HL087641NHLBI NIH HHS R01 HL087652NHLBI NIH HHS R01 HL092111NHLBI NIH HHS R01 HL103612NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL111089NHLBI NIH HHS R01 HL116747NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R01 HL131136NHLBI NIH HHS RC2 HL102419NHLBI NIH HHS U01 HL080295NHLBI NIH HHS U01 HL130114NIA NIH HHS R01 AG023629NINDS NIH HHS R01 NS087541Wellcome Trust 212945/Z/18/ZWellcome Trust 217065/Z/19/ZWellcome Trust WT081878MAWellcome Trust WT092830/Z/10/ZWellcome Trust WT202786/Z/16/Z
Abstract
We performed a multi-ethnic Epigenome Wide Association study on 22,774 individuals to describe the DNA methylation signature of chronic low-grade inflammation as measured by C-Reactive protein (CRP). We find 1,511 independent differentially methylated loci associated with CRP. These CpG sites show correlation structures across chromosomes, and are primarily situated in euchromatin, depleted in CpG islands. These genomic loci are predominantly situated in transcription factor binding sites and genomic enhancer regions. Mendelian randomization analysis suggests altered CpG methylation is a consequence of increased blood CRP levels. Mediation analysis reveals obesity and smoking as important underlying driving factors for changed CpG methylation. Finally, we find that an activated CpG signature significantly increases the risk for cardiometabolic diseases and COPD.
Indexed as
DNA MethylationInflammationCpG IslandsC-Reactive ProteinHumansNucleotide MotifsC-Reactive Protein
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