Evidence map›Paper›PMID 35504799›Full record

ArticleZeitschrift fur medizinische Physik2022

Single-isocenter stereotactic radiosurgery for multiple brain metastases: Impact of patient misalignments on target coverage in non-coplanar treatments.

Michael Martin Eder, Michael Reiner, Christian Heinz, Sylvia Garny, Philipp Freislederer, Guillaume Landry, Maximilian Niyazi, Claus Belka, Marco Riboldi

Abstract read
In one paragraph

Article in Zeitschrift fur medizinische Physik, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  6. Single and multitarget stereotactic radiosurgery (SRS) with single isocenter in the treatment of multiple brain metastases (BM): institutional experience.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Michael Martin EderDepartment of Radiation Oncology, University Hospital, LMU Munich, Munich, Germany; Department of Medical Physics, Ludwig-Maximilians University, Garching, Germany. Electronic address: mi.eder@protonmail.com.
Michael ReinerDepartment of Radiation Oncology, University Hospital, LMU Munich, Munich, Germany. Electronic address: michael.reiner@med.uni-muenchen.de.
Christian HeinzDepartment of Radiation Oncology, University Hospital, LMU Munich, Munich, Germany. Electronic address: christian.heinz@med.uni-muenchen.de.
Sylvia GarnyDepartment of Radiation Oncology, University Hospital, LMU Munich, Munich, Germany. Electronic address: sylvia.garny@med.uni-muenchen.de.
Philipp FreisledererDepartment of Radiation Oncology, University Hospital, LMU Munich, Munich, Germany. Electronic address: philipp.freislederer@med.uni-muenchen.de.
Guillaume LandryDepartment of Radiation Oncology, University Hospital, LMU Munich, Munich, Germany; Department of Medical Physics, Ludwig-Maximilians University, Garching, Germany. Electronic address: guillaume.landry@med.uni-muenchen.de.
Maximilian NiyaziDepartment of Radiation Oncology, University Hospital, LMU Munich, Munich, Germany; German Cancer Consortium (DKTK), Partner Site Munich, Munich, Germany. Electronic address: maximilian.niyazi@med.uni-muenchen.de.
Claus BelkaDepartment of Radiation Oncology, University Hospital, LMU Munich, Munich, Germany; German Cancer Consortium (DKTK), Partner Site Munich, Munich, Germany. Electronic address: claus.belka@med.uni-muenchen.de.
Marco RiboldiDepartment of Radiation Oncology, University Hospital, LMU Munich, Munich, Germany. Electronic address: marco.riboldi@physik.uni-muenchen.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Frameless single-isocenter non-coplanar stereotactic radiosurgery (SRS) for patients with multiple brain metastases is a treatment at high geometrical complexity. The goal of this study is to analyze the dosimetric impact of non-coplanar image guidance with stereoscopic X-ray imaging. Such an analysis is meant to provide insights on the adequacy of safety margins, and to evaluate the benefit of imaging at non-coplanar configurations. The ExacTrac® (ET) system (Brainlab AG, Munich, Germany) was used for stereoscopic X-ray imaging in frameless single-isocenter non-coplanar SRS for multiple brain metastases. Sub-millimeter precision was found for the ET-based pre-treatment setup, whereas a degradation was noted for non-coplanar treatment angles. Misalignments without intra-fractional positioning corrections were reconstructed in 6 degrees of freedom (DoF) to resemble the situation without non-coplanar image guidance. Dose recalculation in 20 SRS patients with applied positioning corrections did not reveal any significant differences in D

Indexed as

Brain NeoplasmsRadiosurgeryGermanyHumansRadiometryRadiotherapy DosageRadiotherapy Planning, Computer-AssistedMultiple brain metastasesNon-coplanarPatient positioningSingle-isocenterStereoscopic X-ray imagingStereotactic radiosurgery

Identifiers

PMID35504799
PMCPMC9948862

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.