Evidence map›Paper›PMID 35504726›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2022

Ubiquitin-Specific Protease 2 in the Ventromedial Hypothalamus Modifies Blood Glucose Levels by Controlling Sympathetic Nervous Activation.

Mayuko Hashimoto, Masaki Fujimoto, Kohtarou Konno, Ming-Liang Lee, Yui Yamada, Koya Yamashita, Chitoku Toda, Michio Tomura, Masahiko Watanabe, Osamu Inanami and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
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  11. Review
  12. Article
  13. Targeting the deubiquitinaseOncology reports · 2023
    Review
  14. Review
  15. Ubiquitin-Specific Proteases (USPs) and Metabolic Disorders.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Mayuko HashimotoLaboratory of Veterinary Physiology, Department of Veterinary Medicine, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu 0698501, Japan.
Masaki FujimotoLaboratories of Radiation Biology and.
Kohtarou KonnoDepartment of Anatomy and Embryology, Graduate School of Medicine, Hokkaido University, Sapporo 0600808, Japan.
Ming-Liang LeeBiochemistry, Faculty of Veterinary Medicine, Hokkaido University, Sapporo 0600808, Japan.
Yui YamadaLaboratory of Veterinary Physiology, Department of Veterinary Medicine, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu 0698501, Japan.
Koya YamashitaLaboratories of Radiation Biology and.ORCID https://orcid.org/0000-0002-9471-7533
Chitoku TodaBiochemistry, Faculty of Veterinary Medicine, Hokkaido University, Sapporo 0600808, Japan.
Michio TomuraLaboratory of Immunology, Faculty of Pharmacy, Osaka Ohtani University, Tondabayashi 5848450, Japan.
Masahiko WatanabeDepartment of Anatomy and Embryology, Graduate School of Medicine, Hokkaido University, Sapporo 0600808, Japan.ORCID https://orcid.org/0000-0001-5037-7138
Osamu InanamiLaboratories of Radiation Biology and.
Hiroshi KitamuraLaboratory of Veterinary Physiology, Department of Veterinary Medicine, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu 0698501, Japan ktmr@rakuno.ac.jp.ORCID https://orcid.org/0000-0001-9643-3211
Applied Science Laboratories (United States) · USHokkaido University · JPHokkaido University of Science · JPOsaka Ohtani University · JPRakuno Gakuen University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ubiquitin-specific protease 2 (USP2) participates in glucose metabolism in peripheral tissues such as the liver and skeletal muscles. However, the glucoregulatory role of USP2 in the CNS is not well known. In this study, we focus on USP2 in the ventromedial hypothalamus (VMH), which has dominant control over systemic glucose homeostasis. ISH, using a

Indexed as

Blood GlucoseNeuroblastomaSympathetic Nervous SystemUbiquitin ThiolesteraseVentromedial Hypothalamic NucleusAMP-Activated Protein KinasesAnimalsGlucoseHumansMaleMiceNorepinephrineOxidative PhosphorylationReactive Oxygen SpeciesAMP-Activated Protein KinasesBlood GlucoseGlucoseNorepinephrineReactive Oxygen SpeciesUbiquitin ThiolesteraseUSP2 protein, humanUsp2 protein, mousehypothalamusmitochondriareactive oxygen speciesubiquitin-specific protease 2ventromedial hypothalamus

Identifiers

PMID35504726
PMCPMC9186793
OpenAlexW4225429091

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.