Evidence map›Paper›PMID 35504656›Full record

ArticleDrug metabolism and disposition: the biological fate of chemicals2022

Regulation of Blood-Brain Barrier Transporters by Transforming Growth Factor-

Robert D Betterton, Wazir Abdullahi, Erica I Williams, Jeffrey J Lochhead, Hrvoje Brzica, Joshua Stanton, Elizabeth Reddell, Chidinma Ogbonnaya, Thomas P Davis, Patrick T Ronaldson

Open access · bronzeAbstract read
In one paragraph

Article in Drug metabolism and disposition: the biological fate of chemicals, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Robert D BettertonDepartment of Pharmacology, College of Medicine, University of Arizona, Tucson, Arizona.
Wazir AbdullahiDepartment of Pharmacology, College of Medicine, University of Arizona, Tucson, Arizona.
Erica I WilliamsDepartment of Pharmacology, College of Medicine, University of Arizona, Tucson, Arizona.
Jeffrey J LochheadDepartment of Pharmacology, College of Medicine, University of Arizona, Tucson, Arizona.
Hrvoje BrzicaDepartment of Pharmacology, College of Medicine, University of Arizona, Tucson, Arizona.
Joshua StantonDepartment of Pharmacology, College of Medicine, University of Arizona, Tucson, Arizona.
Elizabeth ReddellDepartment of Pharmacology, College of Medicine, University of Arizona, Tucson, Arizona.
Chidinma OgbonnayaDepartment of Pharmacology, College of Medicine, University of Arizona, Tucson, Arizona.
Thomas P DavisDepartment of Pharmacology, College of Medicine, University of Arizona, Tucson, Arizona.
Patrick T RonaldsonDepartment of Pharmacology, College of Medicine, University of Arizona, Tucson, Arizona pronald@email.arizona.edu.
University of Arizona · US

Funding

Targeting Blood-Brain Barrier Transporters to Treat Ischemic StrokeR01NS084941 · NINDS · UNIVERSITY OF ARIZONA · PI RONALDSON, PATRICK THOMAS · 2014 to 2024
$4.4M
Increased CNS Opioid Exposure by an Acetaminophen-Induced Blood-Brain Barrier MechanismR01DA051812 · NIDA · UNIVERSITY OF ARIZONA · PI DAVIS, THOMAS PAUL, RONALDSON, PATRICK THOMAS · 2020 to 2024
$2.8M
UA Environmental Health Transformative Research Undergrad Experience(EH TRUE)R25ES025494 · NIEHS · UNIVERSITY OF ARIZONA · PI CHEN, YIN · 2015 to 2024
$1.1M
NIDA NIH HHS R01 DA051812NIEHS NIH HHS R25 ES025494NINDS NIH HHS R01 NS084941
6 · The paper itself

Abstract

Our laboratory has shown that activation of transforming growth factor-

Indexed as

Hydroxymethylglutaryl-CoA Reductase InhibitorsNeoplasmsOrganic Anion TransportersActivin ReceptorsAnimalsATP Binding Cassette Transporter, Subfamily B, Member 1ATP Binding Cassette Transporter, Subfamily G, Member 2Blood-Brain BarrierBrainCoenzyme AEnzyme InhibitorsGrowth Differentiation Factor 2Neoplasm ProteinsOxidoreductasesRatsTransforming Growth Factor betaActivin ReceptorsAcvrl1 protein, ratATP Binding Cassette Transporter, Subfamily B, Member 1ATP Binding Cassette Transporter, Subfamily G, Member 2Coenzyme AEnzyme InhibitorsGrowth Differentiation Factor 2Hydroxymethylglutaryl-CoA Reductase InhibitorsNeoplasm ProteinsOrganic Anion TransportersOxidoreductasesTransforming Growth Factor betaTransforming Growth Factors

Identifiers

PMID35504656
PMCPMC11022862
OpenAlexW4225292367

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.