ArticleCell proliferation2022
GFI1 regulates chromatin state essential in human endothelial-to-haematopoietic transition.
Article in Cell proliferation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 7 citations in OpenAlex.
- Identification of Trogocytosis as an Essential Limitation Factor in hPSC-derived CAR Macrophages.International journal of biological sciences · 2026Article
- Article
- Human induced pluripotent stem cells derived neutrophils display strong anti-microbial potencies.Cell regeneration (London, England) · 2025Article
- FLT1 and other candidate fetal haemoglobin modifying loci in sickle cell disease in African ancestries.Nature communications · 2025Article
- Large-scale generation of IL-12 secreting macrophages from human pluripotent stem cells for cancer therapy.Molecular therapy. Methods & clinical development · 2024Article
- Exploring the role of theFrontiers in genetics · 2024Article
- GFI1 regulates chromatin state essential in human endothelial-to-haematopoietic transition.Cell proliferation · 2022Article
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
Abstract
objectivesDuring embryonic haematopoiesis, haematopoietic stem/progenitor cells (HSPCs) develop from hemogenic endothelial cells (HECs) though endothelial to haematopoietic transition (EHT). However, little is known about how EHT is regulated in human. Here, we report that GFI1 plays an essential role in enabling normal EHT during haematopoietic differentiation of human embryonic stem cells (hESCs).
resultsGFI1 deletion in hESCs leads to a complete EHT defect due to a closed chromatin state of hematopoietic genes in HECs. Mechanically, directly regulates important signaling pathways essential for the EHT such as PI3K signaling.etc. CONCLUTIONS: Together, our findings reveal an essential role of GFI1 mediated epigenetic mechanism underlying human EHT during hematopoiesis.
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