Evidence map›Paper›PMID 35504410›Full record

ArticleBehavioural processes2022

Oral antibiotics reduce voluntary exercise behavior in athletic mice.

Monica P McNamara, Marcell D Cadney, Alberto A Castro, David A Hillis, Kelly M Kallini, John C Macbeth, Margaret P Schmill, Nicole E Schwartz, Ansel Hsiao, Theodore Garland

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Behavioural processes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Microbiota influence on behavior: Integrative analysis of serotonin metabolism and behavioral profile in germ-free mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024
    Article
  4. Journal of inflammation research · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Monica P McNamaraDepartment of Evolution, Ecology, and Organismal Biology, University of California, Riverside, CA 91521, USA.
Marcell D CadneyDepartment of Evolution, Ecology, and Organismal Biology, University of California, Riverside, CA 91521, USA.
Alberto A CastroDepartment of Evolution, Ecology, and Organismal Biology, University of California, Riverside, CA 91521, USA.
David A HillisGenetics, Genomics, and Bioinformatics Graduate Program, University of California, Riverside, CA 91521, USA.
Kelly M KalliniDepartment of Evolution, Ecology, and Organismal Biology, University of California, Riverside, CA 91521, USA.
John C MacbethDepartment of Microbiology and Plant Pathology, University of California, Riverside, CA 91521, USA; Division of Biomedical Sciences, School of Medicine, University of California, Riverside, CA 91521, USA.
Margaret P SchmillNeuroscience Graduate Program, University of California, Riverside, CA 92521, USA.
Nicole E SchwartzDepartment of Evolution, Ecology, and Organismal Biology, University of California, Riverside, CA 91521, USA.
Ansel HsiaoDepartment of Microbiology and Plant Pathology, University of California, Riverside, CA 91521, USA.
Theodore GarlandDepartment of Evolution, Ecology, and Organismal Biology, University of California, Riverside, CA 91521, USA. Electronic address: tgarland@ucr.edu.
University of California, Riverside · US

Funding

Gut microbiome-mediated small-molecule signaling and resistance to invading microorganismsR35GM124724 · NIGMS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI HSIAO, ANSEL · 2017 to 2021
$1.8M
NIGMS NIH HHS R35 GM124724
6 · The paper itself

Abstract

The gut microbiome can affect various aspects of both behavior and physiology, including exercise ability, but effects on voluntary exercise have rarely been studied. We studied females from a selection experiment in which 4 replicate High Runner (HR) lines of mice are bred for voluntary exercise and compared with 4 non-selected control (C) lines. HR and C mice differ in several traits that likely interact with the gut microbiome, including higher daily running distance, body temperatures when running, spontaneous physical activity when housed without wheels, and food consumption. After two weeks of wheel access to reach a stable plateau in daily running, mice were administered broad-spectrum antibiotics for 10 days. Antibiotic treatment caused a significant reduction in daily wheel-running distance in the HR mice (-21%) but not in the C mice. Antibiotics did not affect body mass or food consumption in either HR or C mice, and we did not observe sickness behavior. Wheel running by HR mice did not recover during the 12 days following cessation of antibiotics. The decreased wheel-running in HR but not C mice, with no apparent negative side effects of antibiotics, suggests that the HR microbiome is an important component of their high-running phenotype.

Indexed as

Physical Conditioning, AnimalSportsAnimalsAnti-Bacterial AgentsFemaleMiceMotor ActivityPhenotypeAnti-Bacterial AgentsAntibioticsBehaviorExerciseGut microbiotaHost-microbe interactionWheel running

Identifiers

PMID35504410
PMCPMC9725099
OpenAlexW4225130152

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.