ArticleEnvironmental research2022
A nested case-control study of serum polychlorinated biphenyls and papillary thyroid cancer risk among U.S. military service members.
Article in Environmental research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Assessment of five typical environmental endocrine disruptors and thyroid cancer risk: a meta-analysis.Frontiers in endocrinology · 2023Pooled it
- Chemical exposures as risk factors for the development of thyroid cancer.The oncologist · 2026Review
- Article
- Multi-modal integration of histopathology and transcriptomics reveals STAB1Journal of translational medicine · 2025Article
- Serum concentrations of persistent endocrine-disrupting chemicals in U.S. military personnel: A comparison by race/ethnicity and sex.International journal of hygiene and environmental health · 2025Article
- Differential effects of fine particulate matter constituents on acute coronary syndrome onset.Nature communications · 2024Article
- Thyroid cancer and endocrine disruptive chemicals: a case-control study on per-fluoroalkyl substances and other persistent organic pollutants.European thyroid journal · 2024Article
- Endocrine disrupting chemical mixture exposure and risk of papillary thyroid cancer in U.S. military personnel: A nested case-control study.The Science of the total environment · 2024Article
- Prediagnostic serum concentrations of per- and polyfluoroalkyl substances and risk of papillary thyroid cancer in the Finnish Maternity Cohort.International journal of cancer · 2024Article
- A Facile and Rapid Strategy for Quantifying PCBs in Cereals Based on Dispersive Solid-Phase Extraction and Gas Chromatography-Mass Spectrometry: A Reference for Safety Concerns in Sustainable Textiles.Materials (Basel, Switzerland) · 2023Article
- Review
- Sociodemographic Disparities in the Diagnostic Management of Pediatric Thyroid Nodules.JAMA otolaryngology-- head & neck surgery · 2022Article
Corrections and comments
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Authors and funding
15 authors at 7 institutions in 1 country.
Funding
Abstract
BACKGROUND AND
objectivesAlthough polychlorinated biphenyls (PCBs) were banned decades ago, populations are continuously exposed to PCBs due to their persistence and bioaccumulation/biomagnification in the environment. Results from limited epidemiologic studies linking PCBs to thyroid cancer have been inconclusive. This study aimed to investigate the association between individual PCBs and PCB mixture and papillary thyroid cancer (PTC), the most common thyroid cancer histologic subtype.
methodsWe carried out a nested case-control study including 742 histologically confirmed PTC cases diagnosed in 2000-2013 and 742 individually matched controls among U.S. military service members. Pre-diagnostic serum samples that were collected on average nine years before PTC diagnosis were used to measure PCB congeners by gas chromatography isotope dilution high resolution mass spectrometry (GC/ID-HRMS). Conditional logistic regression, Bayesian kernel machine regression (BKMR), and weighted quantile sum (WQS) regression were employed to estimate the association between single PCB congeners as well as their mixture and PTC.
resultsFour PCB congeners (PCB-74, PCB-99, PCB-105, PCB-118) had significant associations and dose-response relationships with increased risk of PTC in single congener models. When considering the effects from all measured PCBs and their potential interactions in the BKMR model, PCB-118 showed positive trends of association with PTC. Increased exposure to the PCB congeners as a mixturewas also associated with an increased risk of PTC in the WQS model, with the mixture dominated by PCB-118, followed by PCB-74 and PCB-99. One PCB congener, PCB-187, showed an inverse trend of association with PTC in the mixture analysis. DISCUSSION: This study suggests that exposure to certain PCBs as well as a mixture of PCBs were associated with an increased risk of PTC. The observed association was mainly driven by PCB-118, and to a lesser extent by PCB-74 and PCB-99. The findings warrant further investigation.
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Registered trials
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