Evidence map›Paper›PMID 35504280›Full record

ReviewCell2022

Atherosclerosis: Recent developments.

Johan L M Björkegren, Aldons J Lusis

Registry-linked trialOpen access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07659951 (The Effect of Motivational Interviewing on Healthy Lifestyle Behaviors and Biochemical Parameters in Patients Undergoing Stent Implantation After Coronary Angiography), which is not on this map. Cited by 663 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
663citing papers in PubMed, 1 pooled it
87.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07659951 nacompletednot on this mapstarted 2025, after this paper: background citation

The Effect of Motivational Interviewing on Healthy Lifestyle Behaviors and Biochemical Parameters in Patients Undergoing Stent Implantation After Coronary Angiography

TypeinterventionalSponsorBiruni UniversityRan2025 to 2026Enrolled55ConditionsCoronary Artery DiseaseArmsMotivational Interviewing
3 · Its place in the literature

Who cites it

663 citing papers in PubMed, 1 synthesis or guideline pooled it, 1,100 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Review
  6. Article
  7. Article
  8. The histone deacetylase family in health and disease.Signal transduction and targeted therapy · 2026
    Review
  9. Review
  10. Article
  11. Article
  12. Theaflavin attenuates atherosclerosis by targeting GSK-3β to suppress pyroptosis and Promote Autophagy in macrophages.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Article
  13. Review
  14. Article
  15. Article
  16. Nanomaterials-Based Immunotherapy for Atherosclerosis.Small (Weinheim an der Bergstrasse, Germany) · 2026
    Review
  17. Article
  18. Article
  19. Early atherogenesis: In search of etiology.International journal of cardiology. Cardiovascular risk and prevention · 2026
    Review
  20. Article

603 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Johan L M BjörkegrenDepartment of Genetics and Genomic Sciences, Division of Cardiology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Medicine, Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden. Electronic address: johan.bjorkegren@mssm.edu.
Aldons J LusisDepartment of Medicine/Division of Cardiology, Department of Microbiology, Immunology and Molecular Genetics, Department of Human Genetics, A2-237 Center for the Health Sciences, University of California, Los Angeles, Los Angeles, CA USA. Electronic address: jlusis@mednet.ucla.edu.
Icahn School of Medicine at Mount Sinai · USUniversity of California, Los Angeles · US

Funding

Systems Genetics Dissection of Non-alcoholic SteatohepatitisR01DK117850 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Aldons Jake Lusis · 2019 to 2026
$4.6M
Systems genetics approach to inflammatory mechanisms in atherosclerosisR01HL147883 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LUSIS, ALDONS JAKE · 2019 to 2022
$3.0M
Gut microbiota and metabolite interactions in atherosclerosisR01HL144651 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LUSIS, ALDONS JAKE, REY, FEDERICO E · 2019 to 2022
$2.6M
Biological Mechanisms through which TMAO Promotes AtherosclerosisR01HL148110 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ALLAYEE, HOOMAN, SHIH, DIANA MOUHAN · 2020 to 2023
$2.5M
NHLBI NIH HHS R01 HL144651NHLBI NIH HHS R01 HL147883NHLBI NIH HHS R01 HL148110NIDDK NIH HHS R01 DK117850
6 · The paper itself

Abstract

Atherosclerosis is an inflammatory disease of the large arteries that is the major cause of cardiovascular disease (CVD) and stroke. Here, we review the current understanding of the molecular, cellular, genetic, and environmental contributions to atherosclerosis, from both individual pathway and systems perspectives. We place an emphasis on recent developments, some of which have yielded unexpected biology, including previously unknown heterogeneity of inflammatory and smooth muscle cells in atherosclerotic lesions, roles for senescence and clonal hematopoiesis, and links to the gut microbiome.

Indexed as

AtherosclerosisGastrointestinal MicrobiomeArteriesClonal HematopoiesisHumansMyocytes, Smooth Muscle

Identifiers

PMID35504280
PMCPMC9119695
OpenAlexW4225287557

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.