Evidence map›Paper›PMID 35504266›Full record

ArticleBiofabrication2022

3D bioprinted white adipose model for

Wen Xue, Seok-Yeong Yu, Mitchell Kuss, Yunfan Kong, Wen Shi, Soonkyu Chung, So-Youn Kim, Bin Duan

Open access · greenAbstract read
In one paragraph

Article in Biofabrication, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Wen XueMary and Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, NE, United States of America.
Seok-Yeong YuOlson Center for Women's Health, Department of Obstetrics and Gynecology, College of Medicine, University of Nebraska Medical Center, Omaha, NE, United States of America.
Mitchell KussMary and Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, NE, United States of America.
Yunfan KongMary and Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, NE, United States of America.
Wen ShiMary and Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, NE, United States of America.
Soonkyu ChungDepartment of Nutrition, School of Public Health and Health Sciences, University of Massachusetts Amherst, Amherst, MA, United States of America.
So-Youn KimOlson Center for Women's Health, Department of Obstetrics and Gynecology, College of Medicine, University of Nebraska Medical Center, Omaha, NE, United States of America.
Bin DuanMary and Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, NE, United States of America.ORCID 0000-0002-5647-3793
University of Nebraska Medical Center · USNebraska Medical Center · USUniversity of Massachusetts Amherst · USUniversity of Nebraska–Lincoln · US

Funding

Development of mechanism-based ovarian reserve protecting adjuvant therapies against gonadotoxic therapeutic agentsR01HD096042 · NICHD · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI KIM, SO-YOUN · 2019 to 2023
$1.6M
NICHD NIH HHS R01 HD096042
6 · The paper itself

Abstract

Cancer-associated cachexia (CAC) is a complex metabolic and behavioral syndrome with multiple manifestations that involve systemic inflammation, weight loss, and adipose lipolysis. It impacts the quality of life of patients and is the direct cause of death in 20%-30% of cancer patients. The severity of fat loss and adipose tissue remodeling negatively correlate with patients' survival outcomes. To address the mechanism of fat loss and design potential approaches to prevent the process, it will be essential to understand CAC pathophysiology through white adipose tissue models. In the present study, an engineered human white adipose tissue (eWAT) model based on three-dimensional (3D) bioprinting was developed and induced with pancreatic cancer cell-conditioned medium (CM) to mimic the status of CAC

Indexed as

CachexiaNeoplasmsAdipose TissueAdipose Tissue, WhiteCulture Media, ConditionedHumansLipolysisQuality of LifeCulture Media, ConditionedbrowningECM remodelingengineered 3D human white adipose tissuelipolysisvascularization

Identifiers

PMID35504266
PMCPMC9205601
OpenAlexW4225396323

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.