Evidence map›Paper›PMID 35504223›Full record

ArticleNeuroImage. Clinical2022

Network impact score is an independent predictor of post-stroke cognitive impairment: A multicenter cohort study in 2341 patients with acute ischemic stroke.

J Matthijs Biesbroek, Nick A Weaver, Hugo P Aben, Hugo J Kuijf, Jill Abrigo, Hee-Joon Bae, Mélanie Barbay, Jonathan G Best, Régis Bordet, Francesca M Chappell and 38 more

Open access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage. Clinical, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Cerebral small vessel disease: Recent advances and future directions.International journal of stroke : official journal of the International Stroke Society · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

48 authors at 18 institutions in 9 countries.

J Matthijs BiesbroekDepartment of Neurology and Neurosurgery, UMC Utrecht Brain Center, Utrecht, the Netherlands. Electronic address: j.m.biesbroek@umcutrecht.nl.
Nick A WeaverDepartment of Neurology and Neurosurgery, UMC Utrecht Brain Center, Utrecht, the Netherlands.
Hugo P AbenDepartment of Neurology, Elisabeth Tweesteden Hospital, Tilburg, the Netherlands.
Hugo J KuijfImage Sciences Institute, University Medical Center Utrecht, Utrecht, the Netherlands.
Jill AbrigoDepartment of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Hong Kong SAR, China.
Hee-Joon BaeDepartment of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, South Korea.
Mélanie BarbayDepartment of Neurology, Amiens University Hospital, Laboratory of Functional Neurosciences (UR UPJV 4559), Jules Verne Picardy University, 80054 Amiens Cedex, France.
Jonathan G BestStroke Research Centre, Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, Russell Square House, 10 - 12 Russell Square, London WC1B 5EH, UK.
Régis BordetUniversité Lille, Inserm, CHU Lille, U1172 - LilNCog - Lille Neuroscience & Cognition, F-59000 Lille, France.
Francesca M ChappellNeuroimaging Sciences, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK; UK Dementia Research Institute at the University of Edinburgh, Edinburgh, UK.
Christopher P L H ChenDepartment of Pharmacology, National University of Singapore, Singapore, Singapore; Memory, Aging and Cognition Center, National University Health System, Singapore, Singapore.
Thibaut DondaineUniversité Lille, Inserm, CHU Lille, U1172 - LilNCog - Lille Neuroscience & Cognition, F-59000 Lille, France.
Ruben S van der GiessenDepartment of Neurology, Erasmus Medical Center, Rotterdam, the Netherlands.
Olivier GodefroyDepartment of Neurology, Amiens University Hospital, Laboratory of Functional Neurosciences (UR UPJV 4559), Jules Verne Picardy University, 80054 Amiens Cedex, France.
Bibek GyanwaliDepartment of Pharmacology, National University of Singapore, Singapore, Singapore; Memory, Aging and Cognition Center, National University Health System, Singapore, Singapore.
Olivia K L HamiltonNeuroimaging Sciences, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK; UK Dementia Research Institute at the University of Edinburgh, Edinburgh, UK.
Saima HilalDepartment of Pharmacology, National University of Singapore, Singapore, Singapore; Memory, Aging and Cognition Center, National University Health System, Singapore, Singapore; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.
Irene M C Huenges WajerDepartment of Neurology and Neurosurgery, UMC Utrecht Brain Center, Utrecht, the Netherlands; Experimental Psychology, Helmholtz Institute, Utrecht University, the Netherlands.
Yeonwook KangDepartment of Psychology, Hallym University, Chuncheon, South Korea.
L Jaap KappelleDepartment of Neurology and Neurosurgery, UMC Utrecht Brain Center, Utrecht, the Netherlands.
Beom Joon KimDepartment of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, South Korea.
Sebastian KöhlerDepartment of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, the Netherlands.
Paul L M de KortDepartment of Neurology, Elisabeth Tweesteden Hospital, Tilburg, the Netherlands.
Peter J KoudstaalSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.
Gregory KuchcinskiUniversité Lille, Inserm, CHU Lille, U1172 - LilNCog - Lille Neuroscience & Cognition, F-59000 Lille, France.
Bonnie Y K LamDivision of Neurology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China; Therese Pei Fong Chow Research Centre for Prevention of Dementia, Margaret Kam Ling Cheung Research Centre for Management of Parkinsonism, Gerald Choa Neuroscience Centre, The Chinese University of Hong Kong, Hong Kong SAR, China.
Byung-Chul LeeDepartment of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
Keon-Joo LeeDepartment of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, South Korea.
Jae-Sung LimDepartment of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
Renaud LopesUniversité Lille, Inserm, CHU Lille, U1172 - LilNCog - Lille Neuroscience & Cognition, F-59000 Lille, France.
Stephen D J MakinCentre for Rural Health, University of Aberdeen, Aberdeen, UK.
Anne-Marie MendykUniversité Lille, Inserm, CHU Lille, U1172 - LilNCog - Lille Neuroscience & Cognition, F-59000 Lille, France.
Vincent C T MokDivision of Neurology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China; Therese Pei Fong Chow Research Centre for Prevention of Dementia, Margaret Kam Ling Cheung Research Centre for Management of Parkinsonism, Gerald Choa Neuroscience Centre, The Chinese University of Hong Kong, Hong Kong SAR, China.
Mi Sun OhDepartment of Neurology, Hallym University Sacred Hospital, Hallym Neurological Institute, Hallym University College of Medicine, Anyang, South Korea.
Robert J van OostenbruggeDepartment of Neurology, Maastricht University Medical Center, Maastricht, the Netherlands.
Martine RousselDepartment of Neurology, Amiens University Hospital, Laboratory of Functional Neurosciences (UR UPJV 4559), Jules Verne Picardy University, 80054 Amiens Cedex, France.
Lin ShiDepartment of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Hong Kong SAR, China; BrainNow Research Institute, Shenzhen, Guangdong Province, China.
Julie StaalsDepartment of Neurology, Maastricht University Medical Center, Maastricht, the Netherlands.
Maria Del C Valdés-HernándezNeuroimaging Sciences, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK; UK Dementia Research Institute at the University of Edinburgh, Edinburgh, UK.
Narayanaswamy VenketasubramanianRaffles Neuroscience Centre, Raffles Hospital, Singapore, Singapore.
Frans R J VerheyDepartment of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, the Netherlands.
Joanna M WardlawNeuroimaging Sciences, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK; UK Dementia Research Institute at the University of Edinburgh, Edinburgh, UK.
David J WerringStroke Research Centre, Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, Russell Square House, 10 - 12 Russell Square, London WC1B 5EH, UK.
Xu XinDepartment of Pharmacology, National University of Singapore, Singapore, Singapore; Memory, Aging and Cognition Center, National University Health System, Singapore, Singapore.
Kyung-Ho YuDepartment of Neurology, Hallym University Sacred Hospital, Hallym Neurological Institute, Hallym University College of Medicine, Anyang, South Korea.
Martine J E van ZandvoortDepartment of Neurology and Neurosurgery, UMC Utrecht Brain Center, Utrecht, the Netherlands; Experimental Psychology, Helmholtz Institute, Utrecht University, the Netherlands.
Lei ZhaoBrainNow Research Institute, Shenzhen, Guangdong Province, China.
Geert Jan BiesselsDepartment of Neurology and Neurosurgery, UMC Utrecht Brain Center, Utrecht, the Netherlands.
Inserm · FRUniversity Medical Center Utrecht · NLChinese University of Hong Kong · HKUK Dementia Research Institute · GBCentre Hospitalier Universitaire Amiens-Picardie · FRHallym University · KRNational University Health System · SGSeoul National University · KRElisabeth-TweeSteden Ziekenhuis · NLMaastricht University · NLMaastricht University Medical Centre · NLNational University of Singapore · SGResearch Square (United States) · USUlsan College · KRUtrecht University · NLErasmus MC · NLRaffles Institution · SGUniversity of Aberdeen · GB

Funding

Chief Scientist Office CZB/4/517Wellcome Trust WT088134/Z/09/A
6 · The paper itself

Abstract

backgroundPost-stroke cognitive impairment (PSCI) is a common consequence of stroke. Accurate prediction of PSCI risk is challenging. The recently developed network impact score, which integrates information on infarct location and size with brain network topology, may improve PSCI risk prediction.

aimsTo determine if the network impact score is an independent predictor of PSCI, and of cognitive recovery or decline.

methodsWe pooled data from patients with acute ischemic stroke from 12 cohorts through the Meta VCI Map consortium. PSCI was defined as impairment in ≥ 1 cognitive domain on neuropsychological examination, or abnormal Montreal Cognitive Assessment. Cognitive recovery was defined as conversion from PSCI < 3 months post-stroke to no PSCI at follow-up, and cognitive decline as conversion from no PSCI to PSCI. The network impact score was related to serial measures of PSCI using Generalized Estimating Equations (GEE) models, and to PSCI stratified according to post-stroke interval (<3, 3-12, 12-24, >24 months) and cognitive recovery or decline using logistic regression. Models were adjusted for age, sex, education, prior stroke, infarct volume, and study site.

resultsWe included 2341 patients with 4657 cognitive assessments. PSCI was present in 398/844 patients (47%) <3 months, 709/1640 (43%) at 3-12 months, 243/853 (28%) at 12-24 months, and 208/522 (40%) >24 months. Cognitive recovery occurred in 64/181 (35%) patients and cognitive decline in 26/287 (9%). The network impact score predicted PSCI in the univariable (OR 1.50, 95%CI 1.34-1.68) and multivariable (OR 1.27, 95%CI 1.10-1.46) GEE model, with similar ORs in the logistic regression models for specified post-stroke intervals. The network impact score was not associated with cognitive recovery or decline.

conclusionsThe network impact score is an independent predictor of PSCI. As such, the network impact score may contribute to a more precise and individualized cognitive prognostication in patients with ischemic stroke. Future studies should address if multimodal prediction models, combining the network impact score with demographics, clinical characteristics and other advanced brain imaging biomarkers, will provide accurate individualized prediction of PSCI. A tool for calculating the network impact score is freely available at https://metavcimap.org/features/software-tools/lsm-viewer/.

Indexed as

Cognitive DysfunctionIschemic StrokeStrokeCohort StudiesHumansInfarctionBrain connectomicsDementiaDiffusion-weighted imagingIschaemic strokePost-stroke cognitive impairment

Identifiers

PMID35504223
PMCPMC9079101
OpenAlexW4224952116

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.