Evidence map›Paper›PMID 35504093›Full record

ArticleThe International journal on drug policy2022

Changes in the unregulated opioid drug supply during income assistance payment weeks in Vancouver, Canada: An exploratory analysis.

Melissa Beaulac, Lindsey Richardson, Samuel Tobias, Mark Lysyshyn, Cameron Grant, Lianping Ti

Open access · greenAbstract read
In one paragraph

Article in The International journal on drug policy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Melissa BeaulacBritish Columbia Centre on Substance Use, 400-1045 Howe Street, Vancouver, BC, V6Z 2A9, Canada; Department of Medicine, University of British Columbia, 2775 Laurel Street, Vancouver, BC, V6H 0A5, Canada.
Lindsey RichardsonBritish Columbia Centre on Substance Use, 400-1045 Howe Street, Vancouver, BC, V6Z 2A9, Canada; Department of Sociology, University of British Columbia, 6303 NW Marine Dr., Vancouver, BC, V6T 1Z1, Canada.
Samuel TobiasBritish Columbia Centre on Substance Use, 400-1045 Howe Street, Vancouver, BC, V6Z 2A9, Canada.
Mark LysyshynVancouver Coastal Health Authority, 801-601 West Broadway, Vancouver, BC, V5Z 4C2, Canada; School of Population and Public Health, University of British Columbia, 2206 E. Mall, Vancouver, BC, V6T 1Z3, Canada.
Cameron GrantBritish Columbia Centre on Substance Use, 400-1045 Howe Street, Vancouver, BC, V6Z 2A9, Canada.
Lianping TiBritish Columbia Centre on Substance Use, 400-1045 Howe Street, Vancouver, BC, V6Z 2A9, Canada; Department of Medicine, University of British Columbia, 2775 Laurel Street, Vancouver, BC, V6H 0A5, Canada. Electronic address: bccsu-lt@bccsu.ubc.ca.
British Columbia Centre on Substance Use · CAUniversity of British Columbia · CA

Funding

Evaluation of Drug Checking as a Novel Intervention to Address the Opioid Overdose Crisis Attributable to Fentanyl and its AnaloguesR01DA052381 · NIDA · UNIVERSITY OF BRITISH COLUMBIA · PI TI, LIANPING · 2021 to 2023
$1.4M
CIHR FDN-154320NIDA NIH HHS R01 DA052381
6 · The paper itself

Abstract

backgroundIncreased drug-related harms, including overdoses (poisonings), have been reported in the days around income assistance payments, yet little is known about changes in the unregulated drug supply during this time. In this exploratory analysis, we investigated whether changes in the unregulated opioid drug supply are associated with income assistance payment weeks.

methodsUsing data from drug checking services in Vancouver, BC, we conducted modified Poisson and linear regression models to examine the association between income assistance payment weeks and three key outcomes: (1) proportion of fentanyl positivity among expected opioid samples, (2) fentanyl concentration among fentanyl-positive expected opioid samples, and (3) proportion of benzodiazepine positivity among expected opioid samples.

resultsBetween October 2017 and December 2019, 4306 (90.41%) of expected opioid samples tested positive for fentanyl, and the median fentanyl concentration was 7.0% (quartile [Q]1 - Q3: 5.1% - 9.8%). Income assistance payment week was associated with an increased prevalence of fentanyl positivity among expected opioid samples (prevalence ratio [PR]: 1.03; 95% confidence interval [CI]: 1.00, 1.05); however, we failed to find a statistically significant association between income assistance payment week and fentanyl concentration (regression coefficient: 0.70; 95% CI: 0.44, 1.09). Additionally, income assistance payment week was associated with an increased prevalence of benzodiazepine positivity among expected opioid samples (PR: 1.86; 95% CI: 1.07, 3.24).

conclusionThese findings suggest that during income assistance payment weeks, there may be more fentanyl and benzodiazepines circulating in the unregulated opioid drug supply. The rise in fentanyl and benzodiazepine-adulterated opioids during income assistance payment weeks may be contributing to the increase in illicit drug overdoses seen during this time of the month.

Indexed as

Drug OverdoseIllicit DrugsAnalgesics, OpioidBenzodiazepinesCanadaFentanylHumansAnalgesics, OpioidBenzodiazepinesFentanylIllicit DrugsAdulterationBenzodiazepineDrug checkingFentanylIncome assistanceOverdose

Identifiers

PMID35504093
PMCPMC9247031
OpenAlexW4229044304

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.