Evidence map›Paper›PMID 35503474›Full record

ArticleLung2022

ADAMTS7 Attenuates House Dust Mite-Induced Airway Inflammation and Th2 Immune Responses.

Anil Kumar Jaiswal, Amarjit Mishra

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Lung, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Anil Kumar JaiswalLaboratory of Lung Inflammation, Department of Pathobiology, College of Veterinary Medicine, Auburn University, 254 Greene Hall, 1130 Wire Road, Auburn, AL, 36849, USA.
Amarjit MishraLaboratory of Lung Inflammation, Department of Pathobiology, College of Veterinary Medicine, Auburn University, 254 Greene Hall, 1130 Wire Road, Auburn, AL, 36849, USA. amarjit.mishra@auburn.edu.
Auburn University · US

Funding

Integrative Resource to Develop Translational Strategies to Promote LongevityU24AG051129 · NIA · CALIFORNIA PACIFIC MED CTR RES INSTITUTE · PI CUMMINGS, STEVEN RON, EVANS, DANIEL SPENCER · 2015 to 2019
$5.3M
NIA NIH HHS U24 AG051129
6 · The paper itself

Abstract

purposeADAMTS7 is a secreted metalloproteinase enzyme and proteoglycan associated with the early progression of coronary artery disease. However, there is limited information regarding the role of ADAMTS7 in lung adaptive immunity and inflammation. Thus, we sought to assess whether ADAMTS7 expression in the lung modulates house dust mite (HDM)-induced airway inflammation and Th2 immune response.

methodsThe role of ADAMTS7 in HDM-induced airway disease was assessed in ADAMTS7-deficient (ADAMTS7

resultsADAMTS7

conclusionIn aggregate, we provide compelling evidence that ADAMTS7 plays a pivotal role in allergic airway disease and Th2 immunity and would be an attractive target for asthma.

Indexed as

ADAMTS7 ProteinEosinophiliaHypersensitivityTh2 CellsAdaptive ImmunityAllergensAnimalsCytokinesDendritic CellsDermatophagoides pteronyssinusDisease Models, AnimalHumansInflammationLungMicePyroglyphidaeADAMTS7 ProteinAdamts7 protein, mouseAllergensCytokinesADAMTS7Allergic airway inflammation (AAI)Lung dendritic cellsType 2 immune response

Identifiers

PMID35503474
PMCPMC9205806
OpenAlexW4225393571

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.