Evidence map›Paper›PMID 35502911›Full record

ArticleJournal of virology2022

Peste Des Petits Ruminants Virus N Protein Is a Critical Proinflammation Factor That Promotes MyD88 and NLRP3 Complex Assembly.

Lingxia Li, Wenping Yang, Xiaoxia Ma, Jinyan Wu, Xiaodong Qin, Xiaoan Cao, Jianhua Zhou, Li Jin, Jijun He, Haixue Zheng and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Growth Arrest and DNA Damage Protein 45A Promotes PPRV Replication via the Downregulation of TBK1 Expression to Inhibit IFN-β Signaling Pathway.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Lingxia Li *State Key Laboratory of Veterinary Etiological Biology and OIE/National Foot and Mouth Disease Reference Laboratory, African swine fever Regional Laboratory of China, Lanzhou Veterinary Research Institutegrid.454892.6, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu, China.
Wenping Yang *State Key Laboratory of Veterinary Etiological Biology and OIE/National Foot and Mouth Disease Reference Laboratory, African swine fever Regional Laboratory of China, Lanzhou Veterinary Research Institutegrid.454892.6, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu, China.
Xiaoxia MaBiomedical Research Center, Northwest Minzu University, Lanzhou, Gansu, China.
Jinyan WuState Key Laboratory of Veterinary Etiological Biology and OIE/National Foot and Mouth Disease Reference Laboratory, African swine fever Regional Laboratory of China, Lanzhou Veterinary Research Institutegrid.454892.6, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu, China.
Xiaodong QinState Key Laboratory of Veterinary Etiological Biology and OIE/National Foot and Mouth Disease Reference Laboratory, African swine fever Regional Laboratory of China, Lanzhou Veterinary Research Institutegrid.454892.6, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu, China.
Xiaoan CaoState Key Laboratory of Veterinary Etiological Biology and OIE/National Foot and Mouth Disease Reference Laboratory, African swine fever Regional Laboratory of China, Lanzhou Veterinary Research Institutegrid.454892.6, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu, China.
Jianhua ZhouBiomedical Research Center, Northwest Minzu University, Lanzhou, Gansu, China.
Li JinBiomedical Research Center, Northwest Minzu University, Lanzhou, Gansu, China.
Jijun HeState Key Laboratory of Veterinary Etiological Biology and OIE/National Foot and Mouth Disease Reference Laboratory, African swine fever Regional Laboratory of China, Lanzhou Veterinary Research Institutegrid.454892.6, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu, China.
Haixue ZhengState Key Laboratory of Veterinary Etiological Biology and OIE/National Foot and Mouth Disease Reference Laboratory, African swine fever Regional Laboratory of China, Lanzhou Veterinary Research Institutegrid.454892.6, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu, China.ORCID 0000-0001-6850-1379
Xiangtao LiuState Key Laboratory of Veterinary Etiological Biology and OIE/National Foot and Mouth Disease Reference Laboratory, African swine fever Regional Laboratory of China, Lanzhou Veterinary Research Institutegrid.454892.6, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu, China.
Dan LiState Key Laboratory of Veterinary Etiological Biology and OIE/National Foot and Mouth Disease Reference Laboratory, African swine fever Regional Laboratory of China, Lanzhou Veterinary Research Institutegrid.454892.6, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu, China.ORCID 0000-0002-4831-5103
Youjun ShangState Key Laboratory of Veterinary Etiological Biology and OIE/National Foot and Mouth Disease Reference Laboratory, African swine fever Regional Laboratory of China, Lanzhou Veterinary Research Institutegrid.454892.6, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu, China.
Lanzhou Veterinary Research Institute · CNMinzu University of China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammatory responses play a central role in host defense against invading pathogens. Peste des petits ruminants virus (PPRV) causes highly contagious acute or subacute disease of small ruminants. However, the precise mechanism by which PPRV regulates inflammatory responses remains unknown. Here, we revealed a novel mechanism by which PPRV induces inflammation. Our study showed that PPRV induced the secretion of interleukin 1β (IL-1β) by activating the NF-κB signaling pathway and the NLRP3 inflammasome. Moreover, PPRV replication and protein synthesis were essential for NLRP3 inflammasome activation. Importantly, PPRV N protein promoted NF-κB signaling pathway and NLRP3 inflammasome via direct binding of MyD88 and NLPR3, respectively, and induced caspase-1 cleavage and IL-1β maturation. Biochemically, N protein interacted with MyD88 to potentiate the assembly of MyD88 complex and interacted with NLPR3 to facilitate NLRP3 inflammasome complex assembly by forming an N-NLRP3-ASC ring-like structure, leading to IL-1β secretion. These findings demonstrate a new function of PPRV N protein as an important proinflammation factor and identify a novel underlying mechanism modulating inflammasome assembly and function induced by PPRV.

Indexed as

Myeloid Differentiation Factor 88NLR Family, Pyrin Domain-Containing 3 ProteinNucleocapsid ProteinsPeste-des-petits-ruminants virusAnimalsGoatsInflammasomesInflammationNF-kappa BPeste-des-Petits-RuminantsInflammasomesMyeloid Differentiation Factor 88NF-kappa BNLR Family, Pyrin Domain-Containing 3 ProteinNucleocapsid ProteinsIL-1βNF-κBNLRP3 inflammasomeN proteinPPRV

Identifiers

PMID35502911
PMCPMC9131857
OpenAlexW4225301556

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.