Evidence map›Paper›PMID 35502894›Full record

ArticleeLife2022

Metabolic basis for the evolution of a common pathogenic

Dallas L Mould, Mirjana Stevanovic, Alix Ashare, Daniel Schultz, Deborah A Hogan

Open access · goldAbstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 39 citations in OpenAlex.

  1. A genome-wide screen inJournal of bacteriology · 2026
    Article
  2. Review
  3. Review
  4. mSphere · 2026
    Article
  5. Article
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  9. mBio · 2025
    Article
  10. mBio · 2025
    Article
  11. bioRxiv : the preprint server for biology · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Phage-host interaction inApplied and environmental microbiology · 2025
    Article
  16. Article
  17. Article
  18. Article
  19. Spatial heterogeneity in biofilm metabolism elicited by local control of phenazine methylation.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Dallas L MouldDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, United States.ORCID 0000-0001-6939-1351
Mirjana StevanovicDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, United States.
Alix AshareDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, United States.
Daniel SchultzDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, United States.
Deborah A HoganDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, United States.ORCID 0000-0002-6366-2971
Dartmouth College · US

Funding

Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Fred W Kolling IV · 1985 to 2026
$91.3M
Zhao - Proj 2P20GM130454 · NIGMS · DARTMOUTH COLLEGE · PI Li Song · 2019 to 2026
$27.2M
Understanding the role of RNA-binding protein mutations in cancerP20GM113132 · NIGMS · DARTMOUTH COLLEGE · PI MADDEN, DEAN R · 2016 to 2025
$25.9M
Translational Research CoreP30DK117469 · NIDDK · DARTMOUTH COLLEGE · PI DEAN R MADDEN · 2018 to 2026
$13.9M
HOST-MICROBE INTERACTIONST32AI007519 · NIAID · DARTMOUTH COLLEGE · PI DEBORAH A HOGAN · 1997 to 2026
$5.9M
Regional Hypoxia Impacts the Heterogeneity of Inflammatory Lung DiseaseR01HL122372 · NHLBI · DARTMOUTH-HITCHCOCK CLINIC · PI ASHARE, ALIX · 2015 to 2019
$2.0M
Macrophage Pathogen Interactions in Regional Cystic Fibrosis Lung InflammationK24HL150453 · NHLBI · DARTMOUTH-HITCHCOCK CLINIC · PI ASHARE, ALIX · 2020 to 2024
$542k
NCI NIH HHS P30 CA023108NHLBI NIH HHS K24 HL150453NHLBI NIH HHS R01 HL122372NIAID NIH HHS T32 AI007519NIDDK NIH HHS P30 DK117469NIGMS NIH HHS P20 GM113132NIGMS NIH HHS P20 GM130454
6 · The paper itself

Abstract

Microbes frequently evolve in reproducible ways. Here, we show that differences in specific metabolic regulation rather than inter-strain interactions explain the frequent presence of

Indexed as

Cystic FibrosisPseudomonas aeruginosaBacterial ProteinsGene Expression Regulation, BacterialHumansQuorum SensingTrans-ActivatorsBacterial ProteinsTrans-Activatorscarbon catabolite repressionevolutioninfectious diseaseLasRmicrobiologyPseudomonas aeruginosaquorum sensing

Identifiers

PMID35502894
PMCPMC9224983
OpenAlexW4225292302

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.