Evidence map›Paper›PMID 35502801›Full record

ArticleTransplantation2022

Outcomes of SARS-CoV-2 Infection in Unvaccinated Compared With Vaccinated Solid Organ Transplant Recipients: A Propensity Matched Cohort Study.

Victoria G Hall, Ghadeer Al-Alahmadi, Javier T Solera, Tina Marinelli, Heloise Cardinal, G V Ramesh Prasad, Sacha A De Serres, Debra Isaac, Rahul Mainra, Caroline Lamarche and 5 more

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Transplantation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 31 citations in OpenAlex.

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  12. Severity of COVID-19 among solid organ transplant recipients in Canada, 2020-2021: a prospective, multicentre cohort study.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2022
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 2 countries.

Victoria G HallTransplant Infectious Diseases and Multi-Organ Transplant Program, University Health Network, Toronto, ON, Canada.
Ghadeer Al-AlahmadiTransplant Infectious Diseases and Multi-Organ Transplant Program, University Health Network, Toronto, ON, Canada.
Javier T SoleraTransplant Infectious Diseases and Multi-Organ Transplant Program, University Health Network, Toronto, ON, Canada.
Tina MarinelliTransplant Infectious Diseases and Multi-Organ Transplant Program, University Health Network, Toronto, ON, Canada.
Heloise CardinalDepartment of Medicine, University of Montreal, Montreal, QC, Canada.
G V Ramesh PrasadKidney Transplant Program, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada.
Sacha A De SerresTransplantation Unit, Renal Division, Department of Medicine, University Health Center of Quebec, Faculty of Medicine, Laval University, Québec, QC, Canada.
Debra IsaacDivision of Transplant Medicine, University of Calgary, Calgary, AB, Canada.
Rahul MainraSaskatchewan Transplant Program, Transplantation Unit, Renal Division, Department of Medicine, University Health Center of Saskatchewan, Saskatoon, SK, Canada.
Caroline LamarcheHôpital Maisonneuve-Rosemont Research Institute, Université de Montréal, Montréal, QC, Canada.
Ruth Sapir-PichhadzeCentre for Outcomes Research and Evaluation, Research Institute of McGill University Health Centre, Montreal, QC, Canada.
Susan GilmourStollery Children's Hospital, University of Alberta, Edmonton, AB, Canada.
John MatelskiBiostatistics Research Unit, University Health Network, Toronto, ON, Canada.
Atul HumarTransplant Infectious Diseases and Multi-Organ Transplant Program, University Health Network, Toronto, ON, Canada.
Deepali KumarTransplant Infectious Diseases and Multi-Organ Transplant Program, University Health Network, Toronto, ON, Canada.
University Health Network · CARoyal Prince Alfred Hospital · AUMcGill University Health Centre · CAUniversité de Montréal · CAUniversité Laval · CA

Funding

CIHR ERG-477200
6 · The paper itself

Abstract

backgroundSolid organ transplant (SOT) recipients are at high risk for complications from coronavirus disease 2019 (COVID-19). Vaccination may mitigate this risk; however, immunogenicity appears to be significantly impaired, with reports of increased risk of breakthrough infection. It is unknown if vaccine breakthrough infections are milder or as severe as infections in unvaccinated patients.

methodsWe performed a multicenter matched cohort study between March 2020 and September 2021 to assess influence of COVID-19 vaccination on outcomes of COVID-19 infection. Treatment characteristics and disease severity outcomes were compared on the basis of vaccine status; breakthrough infections versus unvaccinated infections. Variable ratio propensity score matching based on age, sex, transplant type, and number of comorbidities, was used to develop the analytic cohort. Logistic regression was used to assess the influence of vaccination status on the selected outcomes.

resultsFrom a cohort of 511 SOT patients with COVID-19, we matched 77 partially or fully vaccinated patients with 220 unvaccinated patients. Treatment characteristics including use of dexamethasone, remdesivir, and antibiotics did not differ. Vaccinated participants were more likely to receive tocilizumab, 15 of 77 (19.5%) versus 5 of 220 (2.3%), P  < 0.001. Disease severity outcomes including oxygen requirement, mechanical ventilation, and mortality were similar among medically attended vaccine breakthroughs compared with unvaccinated patients.

conclusionsSOT recipients who develop medically attended COVID-19 following 1- or 2-dose vaccination seem to have similar disease severity to unvaccinated patients who develop infection. This is consistent with the requirement that SOT recipients need 3 or more vaccine doses and emphasizes the importance of alternate strategies for this population.

Indexed as

COVID-19COVID-19 VaccinesTransplant RecipientsCohort StudiesHumansOrgan TransplantationVaccinationCOVID-19 Vaccines

Identifiers

PMID35502801
PMCPMC9311277
OpenAlexW4225373079

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.