Evidence map›Paper›PMID 35502669›Full record

Observational studyHypertension (Dallas, Tex. : 1979)2022

Day to Day Blood Pressure Variability Associated With Cerebral Arterial Dilation and White Matter Hyperintensity.

Boyu Zhang, Yajing Huo, Zidong Yang, Huihui Lv, Yilin Wang, Jianfeng Feng, Yan Han, He Wang

Open access · hybridAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Hypertension (Dallas, Tex. : 1979), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Observational
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  5. Brain compliance: a new assessment for clinical practice?Frontiers in cardiovascular medicine · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Boyu ZhangInstitute of Science and Technology for Brain-Inspired Intelligence (B.Z., Z.Y., J.F., H.W.), Fudan University, Shanghai, China.ORCID 0000-0002-7837-8420
Yajing HuoDepartment of Neurology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China (Y. Huo, H.L., Y. Han).
Zidong YangInstitute of Science and Technology for Brain-Inspired Intelligence (B.Z., Z.Y., J.F., H.W.), Fudan University, Shanghai, China.
Huihui LvDepartment of Neurology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China (Y. Huo, H.L., Y. Han).
Yilin WangGeorgetown Preparatory School, Washington DC (Y.W.).
Jianfeng FengInstitute of Science and Technology for Brain-Inspired Intelligence (B.Z., Z.Y., J.F., H.W.), Fudan University, Shanghai, China.
Yan HanDepartment of Neurology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China (Y. Huo, H.L., Y. Han).ORCID 0000-0002-7654-0906
He WangInstitute of Science and Technology for Brain-Inspired Intelligence (B.Z., Z.Y., J.F., H.W.), Fudan University, Shanghai, China.ORCID 0000-0002-2053-9439
Ministry of Education · MEShanghai University of Traditional Chinese Medicine · CNFudan University · CNGeorgetown University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrevious studies suggested blood pressure variability (BPV) might help reveal interactions between blood pressure fluctuation and white matter lesions, and the impact of elevated BPV on white matter hyperintensity (WMH) or cerebral arterial dilation is unclear.

methodsThis retrospective observational study involved 2634 stroke-free individuals (68.6±11.1 years, 50.3% female), who underwent magnetic resonance imaging and magnetic resonance angiography scans, from a single center in Shanghai, China. Measurements for variability of blood pressure were made based on 7 days blood pressure recordings. WMHs were quantified from T2-FLAIR images and further classified as periventricular WMH or deep WMH. M1 segment of middle cerebral artery dilation was assessed from magnetic resonance angiography images. General linear model was used to examine the associations.

resultsBoth increased systolic and diastolic BPV were associated with increased WMH volume (systolic:

conclusionsIncreased BPV might be one of the pathophysiological phenomena involving in the small vessel disease independent of hypertension. Increased BPV might independently contribute to intracranial arterial dilation. Management of BPV might be a target to preserve cerebrovascular wellness.

Indexed as

HypertensionWhite MatterBlood PressureChinaDilatationFemaleHumansMagnetic Resonance ImagingMaleangiographyblood pressurecerebral small vessel diseasedementiahypertension

Identifiers

PMID35502669
PMCPMC9172904
OpenAlexW4225377986

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.