Evidence map›Paper›PMID 35502645›Full record

ArticleCell proliferation2022

Insight into the antibacterial resistance of graphdiyne functionalized by silver nanoparticles.

Simin Qin, Mo Xie, Shuting Cao, Jiang Li, Lihua Wang, Shi-Hua Luo, Min Lv

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell proliferation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Simin QinDivision of Physical Biology, CAS Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, China.
Mo XieState Key Laboratory of Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts and Telecommunications, Nanjing, China.
Shuting CaoDivision of Physical Biology, CAS Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, China.
Jiang LiDivision of Physical Biology, CAS Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, China.
Lihua WangDivision of Physical Biology, CAS Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, China.
Shi-Hua LuoDepartment of Traumatology, Rui Jin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Min LvThe Interdisciplinary Research Center, Shanghai Synchrotron Radiation Facility, Zhangjiang Laboratory, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai, China.ORCID https://orcid.org/0000-0003-0587-8528
Chinese Academy of Sciences · CNNanjing University of Posts and Telecommunications · CNShanghai Jiao Tong University · CN

Funding

The National Key R&D Program of China 2020YFA0908900The National Natural Science Foundation of China 21974089The National Natural Science Foundation of China 22022410The National Natural Science Foundation of China 31971310The National Natural Science Foundation of China 82050005
6 · The paper itself

Abstract

objectivesSilver nanoparticles (AgNPs) tend to aggregate spontaneously due to larger surface-to-volume ratio, which causes decreased antibacterial activity and even enhanced antimicrobial resistance (AMR). Here, we aim to improve the stability of AgNPs by employing a growth anchor graphdiyne (GDY) to overcome these shortcomings. MATERIALS AND

methodsBacillus subtilis and Escherichia coli were selected to represent gram-positive and gram-negative bacteria, respectively. Transmission electron microscopy (TEM), energy dispersive spectroscopy (EDS), scanning electron microscopy (SEM)-EDS mapping and inductively coupled plasma mass spectrometry (ICP-MS) were carried out to characterize the physiochemical properties of materials. The antimicrobial property was determined by turbidimetry and plate colony-counting methods. The physiology of bacteria was detected by SEM and confocal imaging, such as morphology, reactive oxygen species (ROS) and cell membrane.

resultsWe successfully synthesized a hybrid graphdiyne @ silver nanoparticles (GDY@Ag) by an environment-friendly approach without any reductants. The hybrid showed high stability and excellent broad-spectrum antibacterial activity towards both gram-positive and gram-negative bacteria. It killed bacteria through membrane destruction and ROS production. Additionally, GDY@Ag did not induce the development of the bacterial resistance after repeated exposure.

conclusionsGDY@Ag composite combats bacteria by synergetic action of GDY and AgNPs. Especially, GDY@Ag can preserve its bacterial susceptibility after repeated exposure compared to antibiotics. Our findings provide an avenue to design innovative antibacterial agents for effective sterilization.

Indexed as

Anti-Infective AgentsMetal NanoparticlesAnti-Bacterial AgentsEscherichia coliGram-Negative BacteriaGram-Positive BacteriaGraphiteReactive Oxygen SpeciesSilverAnti-Bacterial AgentsAnti-Infective AgentsgraphdiyneGraphiteReactive Oxygen SpeciesSilver

Identifiers

PMID35502645
PMCPMC9136490
OpenAlexW4225396275

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.