Evidence map›Paper›PMID 35502591›Full record

ArticleEuropean journal of histochemistry : EJH2022

Seasonal changes in the expression of PACAP, VPAC1, VPAC2, PAC1 and testicular activity in the testis of the muskrat (<em>Ondatra zibethicus</em>).

Zeqi Tang, Xiaojie Yuan, Yuming Bai, Yiming Guo, Haolin Zhang, Yingying Han, Zhengrong Yuan, Qiang Weng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of histochemistry : EJH, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Zeqi TangLaboratory of Animal Physiology, College of Biological Sciences and Technology, Beijing Forestry University, Beijing. tangzeqi@bjfu.edu.cn.
Xiaojie YuanLaboratory of Animal Physiology, College of Biological Sciences and Technology, Beijing Forestry University, Beijing. yuanxiaojie@bjfu.edu.cn.
Yuming BaiLaboratory of Animal Physiology, College of Biological Sciences and Technology, Beijing Forestry University, Beijing. baiyu@bjfu.edu.cn.
Yiming GuoLaboratory of Animal Physiology, College of Biological Sciences and Technology, Beijing Forestry University, Beijing. Ac13311397602@bjfu.edu.cn.
Haolin ZhangLaboratory of Animal Physiology, College of Biological Sciences and Technology, Beijing Forestry University, Beijing. haolinzhang@bjfu.edu.cn.
Yingying HanLaboratory of Animal Physiology, College of Biological Sciences and Technology, Beijing Forestry University, Beijing. thingkinghyy@bjfu.edu.cn.
Zhengrong YuanLaboratory of Animal Physiology, College of Biological Sciences and Technology, Beijing Forestry University, Beijing. zryuan@bjfu.edu.cn.
Qiang WengLaboratory of Animal Physiology, College of Biological Sciences and Technology, Beijing Forestry University, Beijing. qiangweng@bjfu.edu.cn.
Beijing Forestry University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pituitary adenylate cyclase-activating polypeptide (PACAP) plays an important role in the steroidogenesis and spermatogenesis in the testis through its receptors PAC1, VPAC1, and VPAC2. In this study, we investigated the seasonal expressions of PACAP, PAC1, VPAC1, VPAC2, luteinizing hormone receptor (LHR), follicle stimulating hormone receptor (FSHR), steroidogenic acute regulatory protein (StAR), 3β-hydroxysteroid dehydrogenase (3β-HSD), and CYP17A1 in the testis of the male muskrat during the breeding season and the non-breeding season. Histologically, we found the presence of Leydig cells, Sertoli cells and all kinds of germ cells in the testis during the breeding season but only Leydig cells, Sertoli cells, spermatogonia and primary spermatocyte during the non-breeding season. The immunohistochemical localizations of PACAP and VPAC1 were identified in the Leydig cells, spermatogonia and spermatozoa during the breeding season while only in Leydig cells and spermatogonia during the non-breeding season, and PAC1 and VPAC2 were localized in the Leydig cells in both seasons, in which LHR, StAR, 3β-HSD and CYP17A1 were also expressed. Meanwhile, protein and mRNA expression levels of PACAP, PAC1, VPAC1, VPAC2, LHR, FSHR, StAR, 3β-HSD and CYP17A1 in the testis during the breeding season were significantly higher than those during the non-breeding season. These results suggested that PACAP may involve in the regulation of, steroidogenesis and spermatogenesis via an endocrine, autocrine or paracrine manner in the testis of the muskrat.

Indexed as

Pituitary Adenylate Cyclase-Activating PolypeptideTestisAnimalsArvicolinaeMaleSeasonsSpermatogenesisPituitary Adenylate Cyclase-Activating Polypeptide

Identifiers

PMID35502591
PMCPMC9119148
OpenAlexW4225276638

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.