ArticleGut and liver2022
Increased Risk of Cancer after Cholecystectomy: A Nationwide Cohort Study in Korea including 123,295 Patients.
Article in Gut and liver, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- The Associations Between Gallstone Disease and Pan-Cancer Incidence Risk Based on Over 13 Million Participants.Cancer medicine · 2025Pooled it
- Long-term risk of colorectal cancer following cholecystectomy: a nationwide cohort study.Surgical endoscopy · 2026Article
- Observational
- How cholecystectomy and gastrectomy contribute to pancreatic cancer development: a review.Annals of medicine and surgery (2012) · 2026Article
- The Causal Role of Bile Acids in Cancers of the Digestive System.Biomedicines · 2026Review
- Gallbladder disease and colorectal cancer: a two-sample bidirectional Mendelian randomization study.Discover oncology · 2026Article
- Cholecystectomy-induced gut dysbiosis and its consequences: bridging animal models and clinical outcomes in narrative review.Translational gastroenterology and hepatology · 2026Review
- Review
- Unveiling the microbial orchestra: exploring the role of microbiota in cancer development and treatment.Discover oncology · 2025Review
- Gallstones, cholecystectomy, and cancer risk: an observational and Mendelian randomization study.Frontiers of medicine · 2025Observational
- Association between Atherogenic index of plasma and gallstones in the United States adults: A cross-sectional analysis of NHANES 2017-2020.Preventive medicine reports · 2025Article
- Increased diagnosis of hepato-biliary-pancreatic cancer after cholecystectomy: a population-based study.Scientific reports · 2025Article
- Effect of smoking on the risk of gastrointestinal cancer after cholecystectomy: A national population-based cohort study.World journal of gastrointestinal surgery · 2024Article
- The association between cholecystectomy and the risk of colorectal cancer: an updated systematic review and meta-analysis of cohort studies.Translational cancer research · 2023Article
- Increased Risk of Cancer after Cholecystectomy.Gut and liver · 2023Article
- Bile acids as carcinogens in the colon and at other sites in the gastrointestinal system.Experimental biology and medicine (Maywood, N.J.) · 2023Review
- Increased risk ofAnnals of gastroenterologyArticle
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background/Aims: Contradictory findings on the association between cholecystectomy and cancer have been reported. We aimed to investigate the risk of all types of cancers or site-specific cancers in patients who underwent cholecystectomy using a nationwide dataset. Methods: Subjects who underwent cholecystectomy from January 1, 2007, to December 31, 2014, who were older than 20 years and who underwent an initial baseline health check-up within 2 years were enrolled. Those who were diagnosed with any type of cancer before the enrollment or within 1 year after enrollment were excluded. Ultimately, patients (n=123,295) who underwent cholecystectomy and age/sex matched population (n=123,295) were identified from the database of the Korean National Health Insurance Service. The hazard ratio (HR) and 95% confidence interval (CI) for cancer were estimated, and Cox regression analysis was performed. Results: The incidence of cancer in the cholecystectomy group was 9.56 per 1,000 person-years and that in the control group was 7.95 per 1,000 person-years. Patients who underwent cholecystectomy showed an increased risk of total cancer (adjusted HR, 1.19; 95% CI, 1.15 to 1.24; p<0.001), particularly leukemia and malignancies of the colon, liver, pancreas, biliary tract, thyroid, pharynx, and oral cavity. In the subgroup analysis according to sex, the risk of developing cancers in the pancreas, biliary tract, thyroid, lungs and stomach was higher in men than in women. Conclusions: Physicians should pay more attention to the possibility of the occurrence of secondary cancers among patients who undergo cholecystectomy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.