Evidence map›Paper›PMID 35502056›Full record

ArticleIndian journal of ophthalmology2022

A short-term chick embryo

Rohini M Nair, Narayana V L Revu, Sucharita Gali, Prathap Reddy Kallamadi, Varsha Prabhu, Radhika Manukonda, Harishankar Nemani, Swathi Kaliki, Geeta K Vemuganti

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Indian journal of ophthalmology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Progress of Cancer Stem Cells in Retinoblastoma.Current stem cell research & therapy · 2024
    Review
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Rohini M NairSchool of Medical Sciences, University of Hyderabad, Hyderabad, India; Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Narayana V L RevuSchool of Medical Sciences, University of Hyderabad, Hyderabad, India.
Sucharita GaliSchool of Medical Sciences, University of Hyderabad, Hyderabad, India.
Prathap Reddy KallamadiAnimal Facility, National Institute of Nutrition, Hyderabad, India.
Varsha PrabhuSchool of Medical Sciences, University of Hyderabad, Hyderabad, India.
Radhika ManukondaSchool of Medical Sciences, University of Hyderabad, Hyderabad, India.
Harishankar NemaniAnimal Facility, National Institute of Nutrition, Hyderabad, India.
Swathi KalikiThe Operation Eyesight Universal Institute for Eye Cancer; Ophthalmic Pathology Laboratory, L V Prasad Eye Institute, Hyderabad, India.
Geeta K VemugantiSchool of Medical Sciences, University of Hyderabad, Hyderabad, India.
University of Hyderabad · INNational Institute of Nutrition · INL V Prasad Eye Institute · INUniversity of Pennsylvania · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Cancer stem cells (CSCs) reported in various tumors play a crucial role in tumorigenesis and metastasis of retinoblastoma (Rb). Following the efforts to reduce, replace, and refine the use of mammalian models, we aimed to establish a short-term xenograft for Rb to evaluate the CSC properties of CD133 Methods: Y79 cells were cultured, labeled with two different dyes (CM-Dil Y79 and enhanced green fluorescent protein (eGFP)) and sorted for CD133 Results: Y79 cells formed pink-white raised perivascular nodules with feeder vessels on the CAM with both the types of labeled CD133 Conclusion: This study highlights that CE-CAM is a feasible alternative nonmammalian model for evaluating tumorigenicity and metastatic potential of Y79 CSCs. Increased tumorigenicity and metastatic potential of CD133

Indexed as

Retinal NeoplasmsRetinoblastomaAC133 AntigenAnimalsCell Line, TumorChick EmbryoHeterograftsHumansMammalsNeoplastic Stem CellsAC133 AntigenCancer stem cellschick embryometastasisretinoblastomaXenograft model

Identifiers

PMID35502056
PMCPMC9332960
OpenAlexW4225400768

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.