ArticleDiabetology & metabolic syndrome2022
The relationship between central obesity and bone mineral density: a Mendelian randomization study.
Article in Diabetology & metabolic syndrome, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed.
- The relationship between the polymorphisms and mutations of OPG gene and bone metabolism in postmenopausal women in northwest China.Journal of orthopaedic surgery and research · 2026Article
- Healthy Cardiovascular Status Attenuates the Detrimental Association Between Osteosarcopenic Adiposity and Alzheimer's Disease-Related Dementia: A UK Biobank Cohort Study.Journal of the American Heart Association · 2025Article
- Disentangling the divergent causal pathways underlying the association between body mass index and bone mineral density: a comprehensive Mendelian randomization study.BMC medicine · 2025Article
- Causal inference study of plasma proteins and blood metabolites mediating the effect of obesity-related indicators on osteoporosis.Frontiers in endocrinology · 2025Article
- Correlation of body compositions and bone mineral density in postmenopausal women with different body mass index.Frontiers in endocrinology · 2025Article
- The impact of sarcopenia on prognosis and fruquintinib efficacy in advanced colorectal cancer: a retrospective and mendelian randomization study.Frontiers in immunology · 2025Article
- Links among Obesity, Type 2 Diabetes Mellitus, and Osteoporosis: Bone as a Target.International journal of molecular sciences · 2024Review
- Relative Contribution of Metabolic Syndrome Components in Relation to Obesity and Insulin Resistance in Postmenopausal Osteoporosis.Journal of clinical medicine · 2024Article
- Association of obesity with osteoporotic fracture risk in individuals with bone metabolism-related conditions: a cross sectional analysis.Frontiers in nutrition · 2024Article
- Association between lean body mass to visceral fat mass ratio and bone mineral density in United States population: a cross-sectional study.Archives of public health = Archives belges de sante publique · 2023Article
- The Impact of Metabolic Syndrome on Bone Mass in Men: Systematic Review and Meta-Analysis.Biomedicines · 2023Review
- Causal relationship between breakfast skipping and bone mineral density: a two-sample Mendelian randomized study.Frontiers in endocrinology · 2023Article
- Association of the visceral adiposity index with femur bone mineral density and osteoporosis among the U.S. older adults from NHANES 2005-2020: a cross-sectional study.Frontiers in endocrinology · 2023Article
- Seropositive for hepatitis B and C viruses is associated with the risk of decreased bone mineral density in adults: An analysis of studies from the NHANES database.Frontiers in medicine · 2023Article
- Causal associations of hand grip strength with bone mineral density and fracture risk: A mendelian randomization study.Frontiers in endocrinology · 2022Article
- Causality of anthropometric markers associated with polycystic ovarian syndrome: Findings of a Mendelian randomization study.PloS one · 2022Article
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6 authors.
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Abstract
backgroundThe relationship between obesity and osteoporosis is an important public health issue. The goal of this study was to investigate whether and to what extent central obesity traits affect bone mineral density (BMD).
methodsWe conducted a two-sample Mendelian randomization analysis. Genomewide significant single nucleotide polymorphisms associated with waist circumference, hip circumference, waist-to-hip ratio, waist circumference adjusted by body mass index (WCadjBMI), hip circumference adjusted by BMI (HCadjBMI) and waist-to-hip ratio adjusted by BMI (WHRadjBMI) were obtained from a large-scale database containing 224,459 samples. The BMD summary dataset was obtained from a UK Biobank database including 265,627 participants.
resultsThe results provided strong evidence that the HCadjBMI trait was causally and negatively associated with BMD (β: - 0.135, 95% CI - 0.216 to - 0.054; P = 0.001), while the WHR trait was causally and positively associated with BMD (β: 0.194, 95% CI 0.062 to 0.325, P = 0.004). No significant effects were observed for other traits on BMD.
conclusionsThis study indicates variations in the abilities of different central obesity traits to influence BMD. These results should be considered in further studies and public health measures on obesity and osteoporosis prevention strategies.
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