Evidence map›Paper›PMID 35501825›Full record

ArticleJournal of ovarian research2022

miR-600 promotes ovarian cancer cells stemness, proliferation and metastasis via targeting KLF9.

Lili Shan, Pingping Song, Yangyang Zhao, Na An, Yanqiu Xia, Yue Qi, Hongyan Zhao, Jing Ge

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of ovarian research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
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  5. Advances in ovarian tumor stem cells and therapy.Cell biochemistry and biophysics · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Lili Shan *Department of Gynaecology and Obstetrics, the Veterans General Hospital of Liaoning Province, the Second Affiliated Hospital of Shenyang Medical College, Shenyang, 110002, Liaoning, China.
Pingping Song *Department of Gynaecology and Obstetrics, the Veterans General Hospital of Liaoning Province, the Second Affiliated Hospital of Shenyang Medical College, Shenyang, 110002, Liaoning, China.
Yangyang Zhao *Department of Gynaecology and Obstetrics, the Veterans General Hospital of Liaoning Province, the Second Affiliated Hospital of Shenyang Medical College, Shenyang, 110002, Liaoning, China.
Na AnDepartment of Endoscopy, Northern Theater General Hospital, Shenyang, 110011, Liaoning, China.
Yanqiu XiaDepartment of Neonatology, Northern Theater General Hospital, Shenyang, 110011, Liaoning, China.
Yue QiDepartment of Gynaecology and Obstetrics, the Veterans General Hospital of Liaoning Province, the Second Affiliated Hospital of Shenyang Medical College, Shenyang, 110002, Liaoning, China.
Hongyan ZhaoDepartment of Endoscopy, Northern Theater General Hospital, Shenyang, 110011, Liaoning, China.
Jing GeDepartment of Gynaecology and Obstetrics, the Veterans General Hospital of Liaoning Province, the Second Affiliated Hospital of Shenyang Medical College, Shenyang, 110002, Liaoning, China. jingge1031@163.com.
Shenyang Medical College · CNGeneral Hospital of Shenyang Military Region · CN

Funding

Natural Fund Guidance Program of Liaoning Province 2019-ZD-1072
6 · The paper itself

Abstract

Previous studies have revealed that miRNAs participate in the pathogenesis of ovarian cancer; however, whether miR-600 is also involved remains unclear. In this study, we aimed to investigated the role of miR-600 in ovarian cancer progression. Here, miR-600 expression was significantly upregulated in ovarian cancer tissues and stem cells. Functional studies showed that miR-600 promoted ovarian cancer cell stemness, proliferation and metastasis. Mechanistic studies revealed that Kruppel like factor 9 (KLF9) was indicated as the target of miR-600. The luciferase reporter assay suggested that miR-600 directly bound to the 3'-untranslated region of KLF9. Additionally, miR-600 expression was negatively associated with KLF9 expression in human ovarian cancer tissues. Si-KLF9 partially abolished the discrepancy of self-renewal, growth and metastasis capacity between miR-600 knockdown ovarian cancer cells and control cells. In conclusion, our results suggest that miR-600 promotes ovarian cancer cell stemness, proliferation and metastasis via directly downregulating KLF9, and impairing miR-600 levels may be a new treatment strategy for ovarian cancer in the future.

Indexed as

MicroRNAsOvarian Neoplasms3' Untranslated RegionsCarcinoma, Ovarian EpithelialCell ProliferationFemaleGene Expression Regulation, NeoplasticHumansKruppel-Like Transcription Factors3' Untranslated RegionsKLF9 protein, humanKruppel-Like Transcription FactorsMicroRNAsMIRN600 microRNA, humanKLF9MetastasismiR-600Ovarian cancerStemness

Identifiers

PMID35501825
PMCPMC9063371
OpenAlexW4225299851

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.