ArticleBMC geriatrics2022
Associations between albumin, globulin, albumin to globulin ratio and muscle mass in adults: results from the national health and nutrition examination survey 2011-2014.
Article in BMC geriatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 46 citations in OpenAlex.
- Assessing Clinical Severity and Prognosis in Adolescents With Anorexia Nervosa and Atypical Anorexia Nervosa Using the Albumin-Globulin Ratio.European eating disorders review : the journal of the Eating Disorders Association · 2026Article
- Association between Albumin-to-Globulin Ratio and Periodontitis: A Cross-Sectional and Mendelian Randomisation Analysis.Oral health & preventive dentistry · 2026Article
- Effects of resistance, endurance, and combined exercise training on body composition, glycemic control, and serum albumin in women with type 2 diabetes: A randomized controlled study.Metabolism open · 2026Article
- Gluteus maximus cross-sectional area/density in 1-year mortality prediction for oldest-old hip fracture patients.BMC geriatrics · 2026Article
- Regulatory Mechanisms and Safety Evaluation of Exogenous Progesterone for Suppression of Rutting Behavior in Male Sika Deer (Animals : an open access journal from MDPI · 2026Article
- Muscle mass and function in patients with type 2 diabetes mellitus: a characteristic analysis based on sex, age, and BMI.Frontiers in endocrinology · 2026Article
- Laboratory Biomarker Profiles and Phenotypic Discrimination in Coronary Artery Disease with Metabolic and Renal Comorbidities: A Cross-Sectional Study.International journal of general medicine · 2026Article
- Causal associations among albumin, C-reactive protein, body mass index, and the risk of colorectal cancer.Discover oncology · 2025Article
- Mediation effects of age, intramuscular adipose tissue index and serum albumin on survival status in initial dialysis patients.Renal failure · 2025Article
- Identifying predictors of surgical site infection in closed patellar fracture surgery: a multicenter study.Scientific reports · 2025Article
- Serum Albumin/Globulin Ratio and Cognitive Function in Americans: A Linear Association.Brain and behavior · 2025Article
- Construction and verification of a nomogram to estimate middle-aged and older individuals' susceptibility to sarcopenia.BMC musculoskeletal disorders · 2025Article
- Restless legs syndrome and its association with lower extremity adipose tissue thickness: a novel perspective.Arquivos de neuro-psiquiatria · 2025Article
- The albumin-globulin ratio is associated with periodontitis in American adults: results from the NHANES 2009-2014.Scientific reports · 2025Article
- Association between body folate status and muscle mass: a cross-sectional study of the National Health and Nutrition Examination Survey 2011-2018.Journal of health, population, and nutrition · 2025Article
- Risk Factors and Predictive Models for Sarcopenia in Older Adults.Aging medicine (Milton (N.S.W)) · 2025Article
- Cross-Sectional Associations between Clinical Biochemistry and Nutritional Biomarkers and Sarcopenic Indices of Skeletal Muscle in the Baltimore Longitudinal Study of Aging.The Journal of nutrition · 2025Article
- Cardiorespiratory fitness in stroke patients with different activities of daily living levels: a cross-sectional study.Scientific reports · 2025Article
- The association between serum albumin-globulin ratio and overactive bladder in American adults: a cross-sectional study.European journal of medical research · 2025Article
- Association between myosteatosis or sarcopenia based on abdominal CT and hypertension in systemic lupus erythematosus patients.Lipids in health and disease · 2025Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionChronic inflammation and malnutrition play important roles in muscle loss. Although albumin, globulin and albumin to globulin ratio (AGR) are considered to be useful inflammatory-nutritional biomarkers, their relationship with muscle mass remain unclear. This study aimed to investigate the relationship between them in adults.
methodsWe utilized data from the National Health and Nutrition Examination Survey (NHANES) 2011-2014 for analysis. Data on albumin, globulin, appendicular skeletal muscle mass, body mass index (BMI) and potential confounders (sociodemographic characteristics, medical conditions, laboratory parameters) were extracted and analyzed. We conducted multivariate linear regression models and smooth curve fittings to investigate the association between albumin, globulin, AGR and muscle mass. Subgroup analysis based on gender and muscle mass were performed.
resultsA total of 4110 participants were included, there were 294 participants with low muscle mass (LMM) and 3816 participants with normal muscle mass (NMM). LMM individuals were older, had greater prevalence of diabetes, higher BMI, globulin and triglycerides, lower albumin and AGR. Albumin was positively correlated to muscle mass in men, but negatively correlated with muscle mass in women. There were negative association between globulin and muscle mass, and positive association between AGR and muscle mass among men, but no significant associations were detected among women. Moreover, a linear relationship between albumin, globulin and muscle mass, as well as a non-linear relationship between AGR and muscle mass in men were identified.
conclusionsThe relationships between albumin, globulin, AGR and muscle mass were sex-specific. We speculate these indicators may be useful in assessing muscle mass in men.
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