Evidence map›Paper›PMID 35501712›Full record

ArticleBMC primary care2022

Health alliance for prudent prescribing and yield of antibiotics in a patient-centred perspective (HAPPY PATIENT): a before-and-after intervention and implementation study protocol.

Anders Bjerrum, Ana García-Sangenís, Daniela Modena, Gloria Córdoba, Lars Bjerrum, Athina Chalkidou, Jesper Lykkegaard, Malene Plejdrup Hansen, Jens Søndergaard, Jørgen Nexøe and 26 more

Abstract read
In one paragraph

Article in BMC primary care, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
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  3. Estimating cost savings from reducing antibiotic overprescription in european general practices.The European journal of health economics : HEPAC : health economics in prevention and care · 2026
    Article
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  10. Community pharmacists as antimicrobial resistance stewards: a narrative review on their contributions and challenges in low- and middle-income countries.Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

36 authors.

Anders BjerrumFundació Institut Universitari per a la Recerca a l'Atenció Primària de Salut Jordi Gol, Barcelona, Spain.
Ana García-SangenísFundació Institut Universitari per a la Recerca a l'Atenció Primària de Salut Jordi Gol, Barcelona, Spain.
Daniela ModenaFundació Institut Universitari per a la Recerca a l'Atenció Primària de Salut Jordi Gol, Barcelona, Spain.
Gloria CórdobaUniversity of Copenhagen, Copenhagen, Denmark.
Lars BjerrumUniversity of Copenhagen, Copenhagen, Denmark.
Athina ChalkidouUniversity of Copenhagen, Copenhagen, Denmark.
Jesper LykkegaardDepartment of Public Health, Research Unit for General Practice, University of Southern Denmark, Odense, Denmark.
Malene Plejdrup HansenDepartment of Public Health, Research Unit for General Practice, University of Southern Denmark, Odense, Denmark.
Jens SøndergaardDepartment of Public Health, Research Unit for General Practice, University of Southern Denmark, Odense, Denmark.
Jørgen NexøeDepartment of Public Health, Research Unit for General Practice, University of Southern Denmark, Odense, Denmark.
Ingrid RebnordNORCE Norwegian Research Centre AS, Bergen, Norway.
Isabel SebjørnsenNORCE Norwegian Research Centre AS, Bergen, Norway.
Jette Nygaard JensenThe Department of Clinical Microbiology, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark.
Matilde Bøgelund HansenThe Department of Clinical Microbiology, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark.
Katja TaxisRijksuniversiteit Groningen, Groningen, The Netherlands.
Maarten LambertRijksuniversiteit Groningen, Groningen, The Netherlands.
Ria BenkoRijksuniversiteit Groningen, Groningen, The Netherlands.
Beatriz González López-ValcárcelUniversity of Las Palmas de Gran Canaria and Fundación Canaria Parque Científico Tecnológico, Las Palmas, Spain.
Fabiana RaynalUniversity of Las Palmas de Gran Canaria and Fundación Canaria Parque Científico Tecnológico, Las Palmas, Spain.
Nieves BarragánSpanish Society for Family and Community Medicine, Barcelona, Spain.
Pia TouboulDepartment of Public Health, Nice University Hospital, Nice, France.
Pascale BrunoDepartment of Public Health, Nice University Hospital, Nice, France.
Ruta RadzevicieneLtd Mano Seimos Gydytojas (My Family Doctor), Klapeida, Lithuania.
Lina JarusevicieneLithuanian University of Health Sciences, Kaunas, Lithuania.
Auste BandzaiteLithuanian University of Health Sciences, Kaunas, Lithuania.
Maciek Godycki-CwirkoCentre for Family and Community Medicine, the Faculty of Health Sciences, The Medical University of Lodz, Lodz, Poland.
Anna KowalczykCentre for Family and Community Medicine, the Faculty of Health Sciences, The Medical University of Lodz, Lodz, Poland.
Christos LionisClinic of Social and Family Medicine, School of Medicine, University of Crete, Rethymno, Greece.
Maria-Nefeli KarkanaClinic of Social and Family Medicine, School of Medicine, University of Crete, Rethymno, Greece.
Marilena AnastasakiClinic of Social and Family Medicine, School of Medicine, University of Crete, Rethymno, Greece.
Jamie ColemanEuropean Association for Clinical Pharmacology and Therapeutics, London, UK.
Helena GlasováEuropean Association for Clinical Pharmacology and Therapeutics, London, UK.
Michiel van AgtmaelEuropean Association for Clinical Pharmacology and Therapeutics, London, UK.
Pierre TattevinRennes University Hospital, Rennes, France.
Alicia BorràsUniversity Institute for Patient Care, Barcelona, Spain.
Carl LlorInstitut Català de la Salut, Via Roma Health Centre, c. Manso, 19, 3rd floor, 08015, Barcelona, Spain. carles.llor@gmail.com.ORCID 0000-0001-6644-717X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundExcessive and inappropriate use of antibiotics is the most important driver of antimicrobial resistance. The aim of the HAPPY PATIENT project is to evaluate the adaptation of European Union (EU) recommendations on the prudent use of antimicrobials in human health by evaluating the impact of a multifaceted intervention targeting different categories of healthcare professionals (HCPs) on common community-acquired infectious diseases, especially respiratory and urinary tract infections. METHODS/

designHAPPY PATIENT was initiated in January 2021 and is planned to end in December 2023. The partners of this project include 15 organizations from 9 countries. Diverse HCPs (doctors, nurses, pharmacists, and pharmacy technicians) will be audited by the Audit Project Odense (APO) method before and after an intervention in four different settings: general practice, out of hours services, nursing homes and community pharmacies in four high antibiotic prescribing countries (France, Poland, Greece, and Spain) and one low prescribing country (Lithuania). About 25 individuals from each professional group will be recruited in each country, who will register at least 25 patients with community-acquired infections during each audit period. Shortly before the second registration participants will undertake a multifaceted intervention and will receive the results from the first registration to allow the identification of possible quality problems. At these meetings participants will receive training courses on enhancement of communication skills, dissemination of clinical guidelines with recommendations for diagnosis and treatment, posters for the waiting rooms, and leaflets for patients. The results of the second registration will be compared with those obtained in the first audit. DISCUSSION: HAPPY PATIENT is an EU-funded project aimed at contributing to the battle against antibiotic resistance through improvement of the quality of management of common community-acquired infections based on interventions by different types of HCPs. It is hypothesized that the use of multifaceted strategies combining active intervention will be effective in reducing inappropriate prescribing and dispensing of antibiotics. STUDY REGISTRATION: EU Health programmes project database https://webgate.ec.europa.eu/chafea_pdb/health/projects/900024/summary ; date of registration: 1 January 2021.

Indexed as

Community-Acquired InfectionsRespiratory Tract InfectionsAnti-Bacterial AgentsDrug Resistance, MicrobialHumansInsurance PoolsAnti-Bacterial AgentsAfter-hours careAnti-bacterial agentsAntimicrobial stewardshipMedical auditNursing homesPharmaciesPrimary health care

Identifiers

PMID35501712
PMCPMC9063370

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.