Evidence map›Paper›PMID 35501692›Full record

Observational studyBMC anesthesiology2022

Postoperative pulmonary complications with adjuvant regional anesthesia versus general anesthesia alone: a sub-analysis of the Perioperative Research Network study.

Karsten Bartels, Gyorgy Frendl, Juraj Sprung, Toby N Weingarten, Balachundhar Subramaniam, Ricardo Martinez Ruiz, Jae-Woo Lee, William G Henderson, Angela Moss, Alissa Sodickson and 4 more

Registry-linked trialOpen access · goldAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC anesthesiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07728214 (Reminder-enhanced Incentive Spirometry Evaluation), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07728214 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Reminder-enhanced Incentive Spirometry Evaluation (RISE)

TypeinterventionalSponsorUniversity of Colorado, DenverRan2026 to 2029Enrolled88ConditionsHypoxemiaArmsAlarms ON
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 10 institutions in 1 country.

Karsten BartelsDepartment of Anesthesiology, University of Colorado School of Medicine, 12631 E 17th Ave, AO-1 bldg, R2012, MS 8202, Aurora, CO, 80045, USA.
Gyorgy FrendlBrigham and Women's Hospital, Boston, MA, USA.
Juraj SprungMayo Clinic, Rochester, MN, USA.
Toby N WeingartenMayo Clinic, Rochester, MN, USA.
Balachundhar SubramaniamBeth Israel Deaconess Medical Center, Boston, MA, USA.
Ricardo Martinez RuizUniversity of Miami, Palmetto Bay, FL, USA.
Jae-Woo LeeUniversity of California San Francisco, San Francisco, CA, USA.
William G HendersonAdult and Children Outcomes Research and Delivery Systems (ACCORDS), University of Colorado School of Medicine, Aurora, CO, USA.
Angela MossAdult and Children Outcomes Research and Delivery Systems (ACCORDS), University of Colorado School of Medicine, Aurora, CO, USA.
Alissa SodicksonBrigham and Women's Hospital, Boston, MA, USA.
Jadelis GiquelUniversity of Miami, Palmetto Bay, FL, USA.
Marcos Francisco Vidal MeloColumbia University Irving Medical Center, New York, NY, USA.
Ana Fernandez-BustamanteDepartment of Anesthesiology, University of Colorado School of Medicine, 12631 E 17th Ave, AO-1 bldg, R2012, MS 8202, Aurora, CO, 80045, USA. Ana.Fernandez-Bustamante@cuanschutz.edu.
Perioperative Research Network (PRN) investigators
Brigham and Women's Hospital · USMayo Clinic in Arizona · USUniversity of Colorado Denver · USBeth Israel Deaconess Medical Center · USColumbia University Irving Medical Center · USOutcomes Research Consortium · USPalmetto General Hospital · USUniversity of California, San Francisco · USUniversity of Miami · USUniversity of Nebraska Medical Center · US

Funding

1/2: An Anesthesia-Centered Bundle to Reduce Postoperative Pulmonary Complications: The PRIME-AIR StudyUH3HL140177 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI FERNANDEZ-BUSTAMANTE, ANA, VIDAL MELO, MARCOS F · 2020 to 2023
$6.6M
1/2: An Anesthesia-Centered Bundle to Reduce Postoperative Pulmonary Complications: The PRIME-AIR StudyUG3HL140177 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI FERNANDEZ-BUSTAMANTE, ANA, VIDAL MELO, MARCOS F · 2019 to 2019
$1.2M
Improving Opioid Prescription Safety After SurgeryK23DA040923 · NIDA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BARTELS, KARSTEN · 2016 to 2020
$945k
Intraoperative Protective Ventilation and Postoperative Pulmonary ComplicationsR34HL123438 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI VIDAL MELO, MARCOS F · 2015 to 2017
$599k
NHLBI NIH HHS R34 HL123438NHLBI NIH HHS UG3 HL140177NHLBI NIH HHS UH3 HL140177NIDA NIH HHS K23 DA040923
6 · The paper itself

Abstract

backgroundAdjuvant regional anesthesia is often selected for patients or procedures with high risk of pulmonary complications after general anesthesia. The benefit of adjuvant regional anesthesia to reduce postoperative pulmonary complications remains uncertain. In a prospective observational multicenter study, patients scheduled for non-cardiothoracic surgery with at least one postoperative pulmonary complication surprisingly received adjuvant regional anesthesia more frequently than those with no complications. We hypothesized that, after adjusting for surgical and patient complexity variables, the incidence of postoperative pulmonary complications would not be associated with adjuvant regional anesthesia.

methodsWe performed a secondary analysis of a prospective observational multicenter study including 1202 American Society of Anesthesiologists physical status 3 patients undergoing non-cardiothoracic surgery. Patients were classified as receiving either adjuvant regional anesthesia or general anesthesia alone. Predefined pulmonary complications within the first seven postoperative days were prospectively identified. Groups were compared using bivariable and multivariable hierarchical logistic regression analyses for the outcome of at least one postoperative pulmonary complication.

resultsAdjuvant regional anesthesia was performed in 266 (22.1%) patients and not performed in 936 (77.9%). The incidence of postoperative pulmonary complications was greater in patients receiving adjuvant regional anesthesia (42.1%) than in patients without it (30.9%) (site adjusted p = 0.007), but this association was not confirmed after adjusting for covariates (adjusted OR 1.37; 95% CI, 0.83-2.25; p = 0.165).

conclusionAfter adjusting for surgical and patient complexity, adjuvant regional anesthesia versus general anesthesia alone was not associated with a greater incidence of postoperative pulmonary complications in this multicenter cohort of non-cardiothoracic surgery patients.

Indexed as

Anesthesia, ConductionAnesthesia, GeneralHumansIncidencePostoperative ComplicationsPostoperative PeriodAdjuvant regional anesthesiaGeneral anesthesiaPostoperative pulmonary complicationsRegional anesthesiaSurgical outcomes

Identifiers

PMID35501692
PMCPMC9063185
OpenAlexW4225389615

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.