Evidence map›Paper›PMID 35501658›Full record

ArticleBulletin of experimental biology and medicine2022

Quantitative Assay of B. pertussis Lipopolysaccharide.

M R Nazirov, A V Poddubikov, V G Kukes, N G Sidorov, O K Parfenova

Abstract read
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In one paragraph

Article in Bulletin of experimental biology and medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

M R NazirovI. I. Mechnikov Research Institute of Vaccines and Sera, Moscow, Russia.
A V PoddubikovI. I. Mechnikov Research Institute of Vaccines and Sera, Moscow, Russia.
V G KukesScientific Centre for Expert Evaluation of Medicinal Products, Ministry of the Health of the Russian Federation, Moscow, Russia.
N G SidorovI. I. Mechnikov Research Institute of Vaccines and Sera, Moscow, Russia. deel@yandex.ru.
O K ParfenovaV. N. Orekhovich Research Institute of Biomedical Chemistry, Moscow, Russia.
Research Institute of Vaccines and Sera. Mechnikov of the Russian Academy of Medical Sciences · RUInstitute of Biomedical Chemistry · RUMinistry of Health of the Russian Federation · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We studied activity of Bordetella pertussis LPS in the LAL test. The mean activity of various series of LPS preparations obtained from B. pertussis cells ranged from 1,950,000 to 2,940,000 endotoxin units/μg (EU/μg). Activity of the LPS preparation obtained from the culture medium supernatant was significantly higher (4,640,000 EU/μg). Activity of the control standard E. coli 055:B5 LPS was 19,500±500 EU/μg. These data indicate that activity of the obtained preparations of B. pertussis LPS in the LAL test is 100-200 times higher than activity of E. coli LPS used as a reference control. It was concluded that the results of the LAL test when assessing the permissible content of B. pertussis endotoxins require correction, probably by introducing a correction factor.

Indexed as

LipopolysaccharidesWhooping CoughBordetella pertussisEndotoxinsEscherichia coliHumansEndotoxinsLipopolysaccharidesB. pertussisLAL testlipopolysaccharidepertussis

Identifiers

PMID35501658
OpenAlexW4225388893

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.